146 research outputs found
Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia
Heterostructures for High Performance Devices
Contains table of contents for Part I, table of contents for Section 1, an introduction, reports on sixteen research projects and a list of publications.DARPA/NCIPTJoint Services Electronics Program Contract DAAL03-92-C-0001National Science FoundationToshiba Corporation Ltd.Charles S. Draper LaboratoriesHertz Foundation FellowshipVitesse SemiconductorGTE LaboratoriesNational Science Foundation FellowshipDARPA/MOSISTexas Instruments, Inc.U.S. Army Research Office Grant DAAL03-92-G-025
Heterostructures for High Performance Devices
Contains an introduction, reports on thirteen research projects and a list of publications.Charles S. Draper Laboratory Contract DL-H-418483DARPA/NCIPT Subcontract 542383Joint Services Electronics Program Contract DAAL03-89-C-0001IBM Corporation FellowshipNational Science Foundation FellowshipVitesse SemiconductorAT&T Bell LaboratoriesHertz Foundation FellowshipNational Science FoundationTRWBelgian American Education Foundation (BAEF) FellowshipNational Science Foundation Grant ECS 90-08485Harvard University. Division of Applied PhysicsAT&T Bell Laboratories FellowshipNational Science Foundation Grant ECS 90-0774
Proteomic Profile of Reversible Protein Oxidation Using PROP, Purification of Reversibly Oxidized Proteins
Signal transduction pathways that are modulated by thiol oxidation events are beginning to be uncovered, but these discoveries are limited by the availability of relatively few analytical methods to examine protein oxidation compared to other signaling events such as protein phosphorylation. We report here the coupling of PROP, a method to purify reversibly oxidized proteins, with the proteomic identification of the purified mixture using mass spectrometry. A gene ontology (GO), KEGG enrichment and Wikipathways analysis of the identified proteins indicated a significant enrichment in proteins associated with both translation and mRNA splicing. This methodology also enabled the identification of some of the specific cysteine residue targets within identified proteins that are reversibly oxidized by hydrogen peroxide treatment of intact cells. From these identifications, we determined a potential consensus sequence motif associated with oxidized cysteine residues. Furthermore, because we identified proteins and specific sites of oxidation from both abundant proteins and from far less abundant signaling proteins (e.g. hepatoma derived growth factor, prostaglandin E synthase 3), the results suggest that the PROP procedure was efficient. Thus, this PROP-proteomics methodology offers a sensitive means to identify biologically relevant redox signaling events that occur within intact cells
Heterostructures for High Performance Devices
Contains table of contents for Part I, table of contents for Section 1, an introduction, reports on eighteen research projects and a list of publications.Charles S. Draper Laboratories Contract DL-H-418483DARPA/NCIPTJoint Services Electronics Program Contract DAAL03-89-C-0001Joint Services Electronics Program Contract DAAL03-92-C-0001IBM Corporation FellowshipNational Science Foundation FellowshipVitesse SemiconductorGTE LaboratoriesCharles S. Draper LaboratoriesElectronics and Telecommunications Research Institute (ETRI) FellowshipNational Science Foundation/Northeastern UniversityTRW SystemsU.S. Army Research OfficeNational Science FoundationAT&T Bell Laboratories FellowshipNational Science Foundation Grant ECS 90-0774
The MUSE Atlas of Disks (MAD): resolving star formation rates and gas metallicities on <100 pc scales†
We study the physical properties of the ionized gas in local discs using the sample of 38 nearby ∼108.5–11.2 M⊙ Star-Forming Main-Sequence (SFMS) galaxies observed so far as part of the MUSE Atlas of Disks (MAD). Specifically, we use all strong emission lines in the MUSE wavelength range 4650–9300 Å to investigate the resolved ionized gas properties on ∼100 pc scales. This spatial resolution enables us to disentangle H ii regions from the diffuse ionized gas (DIG) in the computation of gas metallicities and star formation rates (SFRs) of star-forming regions. The gas metallicities generally decrease with radius. The metallicity of the H ii regions is on average ∼0.1 dex higher than that of the DIG, but the metallicity radial gradient in both components is similar. The mean metallicities within the inner galaxy cores correlate with the total stellar mass of the galaxies. On our < 100 pc scales, we find two correlations previously reported at kpc scales: a spatially resolved mass–metallicity relation (RMZR) and a spatially resolved SFMS (RSFMS). We find no secondary dependence of the RMZR with the SFR density. We find that both resolved relations have a local origin, as they do not depend on the total stellar mass. The observational results of this paper are consistent with the inside-out scenario for the growth of galactic disks
Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
Acute Middle East Respiratory Syndrome Coronavirus Infection in Livestock Dromedaries, Dubai, 2014
Magnetic Field Properties inside the Jet of Mrk 421: Multiwavelength Polarimetry Including the Imaging X-ray Polarimetry Explorer
We conducted a polarimetry campaign from radio to X-ray wavelengths of the
high-synchrotron-peak (HSP) blazar Mrk 421, including Imaging X-ray Polarimetry
Explorer (IXPE) measurements on 2022 December 6-8. We detected X-ray
polarization of Mrk 421 with a degree of =141 and an
electric-vector position angle =1073 in the 2-8
keV band. From the time variability analysis, we find a significant episodic
variation in . During 7 months from the first IXPE pointing of
Mrk 421 in 2022 May, varied across the range of 0 to
180, while maintained similar values within
10-15. Furthermore, a swing in in 2022 June was
accompanied by simultaneous spectral variations. The results of the
multiwavelength polarimetry show that the X-ray polarization degree was
generally 2-3 times greater than that at longer wavelengths, while the
polarization angle fluctuated. Additionally, based on radio, infrared, and
optical polarimetry, we find that rotation of occurred in the opposite
direction with respect to the rotation of over longer timescales
at similar epochs. The polarization behavior observed across multiple
wavelengths is consistent with previous IXPE findings for HSP blazars. This
result favors the energy-stratified shock model developed to explain variable
emission in relativistic jets. The accompanying spectral variation during the
rotation can be explained by a fluctuation in the physical
conditions, e.g., in the energy distribution of relativistic electrons. The
opposite rotation direction of between the X-ray and longer-wavelength
polarization accentuates the conclusion that the X-ray emitting region is
spatially separated from that at longer wavelengths.Comment: 17 pages, 13 figures, 4 tables; Accepted for publication in A&
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