139 research outputs found
Compact Nuclei in Galaxies at Moderate Redshift: I. Imaging and Spectroscopy
This study explores the space density and properties of active galaxies to
z=0.8. We have investigated the frequency and nature of unresolved nuclei in
galaxies at moderate redshift as indicators of nuclear activity such as Active
Galactic Nuclei (AGN) or starbursts. Candidates are selected by fitting imaged
galaxies with multi-component models using maximum likelihood estimate
techniques to determine the best model fit. We select those galaxies requiring
an unresolved, point source component in the galaxy nucleus, in addition to a
disk and/or bulge component, to adequately model the galaxy light. We have
searched 70 WFPC2 images primarily from the Medium Deep Survey for galaxies
containing compact nuclei. In our survey of 1033 galaxies, the fraction
containing an unresolved nuclear component greater than 3% of the total galaxy
light is 16+/-3% corrected for incompleteness and 9+/-1% for nuclei greater
than 5% of the galaxy light. Spectroscopic redshifts have been obtained for 35
of our AGN/starburst candidates and photometric redshifts are estimated to an
accuracy of sigma_z=0.1 for the remaining sample. In this paper, the first of
two in this series, we present the selected HST imaged galaxies having
unresolved nuclei and discuss the selection procedure. We also present the
ground-based spectroscopy for these galaxies as well as the photometric
redshifts estimated for those galaxies without spectra.Comment: 56 pages, 22 figures, to appear in ApJ Supplement Series, April 199
Compact Nuclei in Moderately Redshifted Galaxies
The Hubble Space Telescope WFPC2 is being used to obtain high-resolution
images in the V and I bands for several thousand distant galaxies as part of
the Medium Deep Survey (MDS). An important scientific aim of the MDS is to
identify possible AGN candidates from these images in order to measure the
faint end of the AGN luminosity function as well as to study the host galaxies
of AGNs and nuclear starburst systems. We are able to identify candidate
objects based on morphology. Candidates are selected by fitting bulge+disk
models and bulge+disk+point source nuclei models to HST imaged galaxies and
determining the best model fit to the galaxy light profile. We present results
from a sample of MDS galaxies with I less than 21.5 mag that have been searched
for AGN/starburst nuclei in this manner. We identify 84 candidates with
unresolved nuclei in a sample of 825 galaxies. For the expected range of galaxy
redshifts, all normal bulges are resolved. Most of the candidates are found in
galaxies displaying exponential disks with some containing an additional bulge
component. 5% of the hosts are dominated by an r^-1/4 bulge. The V-I color
distribution of the nuclei is consistent with a dominant population of
Seyfert-type nuclei combined with an additional population of starbursts. Our
results suggest that 10% +/- 1% of field galaxies at z less than 0.6 may
contain AGN/starburst nuclei that are 1 to 5 magnitudes fainter than the host
galaxies.Comment: 12 pages AASTeX manuscript, 3 separate Postscript figures, to be
published in ApJ Letter
Compact Nuclei in Galaxies at Moderate Redshift:II. Their Nature and Implications for the AGN Luminosity Function
This study explores the space density and properties of active galaxies to
z=0.8. We have investigated the frequency and nature of unresolved nuclei in
galaxies at moderate redshift as indicators of nuclear activity such as Active
Galactic Nuclei (AGN) or starbursts. Candidates are selected by fitting imaged
galaxies with multi-component models using maximum likelihood estimate
techniques to determine the best model fit. We select those galaxies requiring
an unresolved point-source component in the galaxy nucleus, in addition to a
disk and/or bulge component, to adequately model the galaxy light. We have
searched 70 WFPC2 images primarily from the Medium Deep Survey for galaxies
containing compact nuclei. In our survey of 1033 galaxies, the fraction
containing an unresolved nuclear component greater than 5% of the total galaxy
light is 9+/-1% corrected for incompleteness. In this second of two papers in
this series, we discuss the nature of the compact nuclei and their hosts.
We present the upper limit luminosity function (LF) for low-luminosity AGN
(LLAGN) in two redshift bins to z=0.8. Mild number density evolution is
detected for nuclei at -18 -16
and this flatness, combined with the increase in number density, is
inconsistent with pure luminosity evolution. Based on the amount of density
evolution observed for these objects, we find that almost all present-day
spiral galaxies could have hosted a LLAGN at some point in their lives. We also
comment on the likely contribution of these compact nuclei to the soft X-ray
background.Comment: 50 pages, 14 figures, to appear in ApJ, April 199
EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer
Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti-EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized that PrPC expression levels may regulate EGFR signaling and that detailed understanding of this signaling pathway may enable identification of resistance mechanisms and new actionable targets in colorectal cancer. We performed molecular pathway analysis following knockdown of PrPC or inhibition of EGFR signaling via gefitinib to identify changes in expression of key signaling proteins that determine cellular sensitivity or resistance to cisplatin. Expression of these proteins was examined in matched primary and metastatic patient samples and was correlated for resistance to therapy and progression of disease. Utilizing three colorectal cancer cell lines, we observed a correlation between high expression of PrPC and resistance to cisplatin. Investigation of molecular signaling in a resistant cell line revealed that PrPC contributed to signaling via colocalization with EGFR, which could be overcome by targeting p38 mitogen-activated protein kinases (p38 MAPK). We revealed that the level of KrĂĽppel-like factor 5 (KLF5), a target downstream of p38 MAPK, was predictive for cell line and patient response to platinum agents. Further, high KLF5 expression was observed in BRAF-mutant colorectal cancer. Our study indicates that the EGFR to KLF5 pathway is predictive of patient progression on platinum-based therapy
A V-Band Survey for Variable Galactic Nuclei in the Hubble Deep Field
We present the results of a 2-epoch variability survey in the Hubble Deep
Field with the goal of investigating the population of AGN to z=1. The primary
data sets analyzed for galactic variability are the original HDF observations
obtained in 1995 and a second V-band image obtained 5 years later in 2000. We
find evidence for nuclear variability in 16 of 217 galaxies brighter than
V_nuc=27.5. Correcting for incompleteness and spurious detections, variable
nuclei make up ~8% of the surveyed galaxies. Seven of our variable sources are
coincident with X-ray sources detected in the 2Ms Chandra survey. We find that
44% of the variable nuclei are associated with mid-IR detections at 15 microns
and 31% are detected at 1.4GHz. Optical spectra are available for 13 of the 16
variables. One is a broad-line AGN and 2 others show weak evidence of type 2
AGNs. With the assumption that these variables are all active nuclei, we
estimate the AGN LF at 0.4<z<1.1 extending to M_B=-15. We find evidence for an
increase in the number density of faint AGN when comparing to the local Seyfert
luminosity function. The LF for optically varying nuclei appears to rise in
number density with no evidence of turning over at these faint magnitudes.Comment: 33 pages, 9 figures, to be published in Dec. 2003 Ap
The Type Ia Supernova Rate in Redshift 0.5--0.9 Galaxy Clusters
Supernova (SN) rates are potentially powerful diagnostics of metal enrichment
and SN physics, particularly in galaxy clusters with their deep,
metal-retaining potentials and relatively simple star-formation histories. We
have carried out a survey for supernovae (SNe) in galaxy clusters, at a
redshift range 0.5<z<0.9, using the Advanced Camera for Surveys (ACS) on the
Hubble Space Telescope. We reimaged a sample of 15 clusters that were
previously imaged by ACS, thus obtaining two to three epochs per cluster, in
which we discovered five likely cluster SNe, six possible cluster SNe Ia, two
hostless SN candidates, and several background and foreground events. Keck
spectra of the host galaxies were obtained to establish cluster membership. We
conducted detailed efficiency simulations, and measured the stellar
luminosities of the clusters using Subaru images. We derive a cluster SN rate
of 0.35 SNuB +0.17/-0.12 (statistical) \pm0.13 (classification) \pm0.01
(systematic) [where SNuB = SNe (100 yr 10^10 L_B_sun)^-1] and 0.112 SNuM
+0.055/-0.039 (statistical) \pm0.042 (classification) \pm0.005 (systematic)
[where SNuM = SNe (100 yr 10^10 M_sun)^-1]. As in previous measurements of
cluster SN rates, the uncertainties are dominated by small-number statistics.
The SN rate in this redshift bin is consistent with the SN rate in clusters at
lower redshifts (to within the uncertainties), and shows that there is, at
most, only a slight increase of cluster SN rate with increasing redshift. The
low and fairly constant SN Ia rate out to z~1 implies that the bulk of the iron
mass in clusters was already in place by z~1. The recently observed doubling of
iron abundances in the intracluster medium between z=1 and 0, if real, is
likely the result of redistribution of existing iron, rather than new
production of iron.Comment: Accepted to ApJ. Full resolution version available at
http://kicp.uchicago.edu/~kerens/HSTclusterSNe
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage
During intracerebral hemorrhage (ICH), hematoma formation at the site of blood vessel damage results in local mechanical injury. Subsequently, erythrocytes lyse to release hemoglobin and heme, which act as neurotoxins and induce inflammation and secondary brain injury, resulting in severe neurological deficits. Accelerating hematoma resorption and mitigating hematoma-induced brain edema by modulating immune cells has potential as a novel therapeutic strategy for functional recovery after ICH. Here, we show that intracerebroventricular administration of recombinant human cerebral dopamine neurotrophic factor (rhCDNF) accelerates hemorrhagic lesion resolution, reduces peri-focal edema, and improves neurological outcomes in an animal model of collagenase-induced ICH. We demonstrate that CDNF acts on microglia/macrophages in the hemorrhagic striatum by promoting scavenger receptor expression, enhancing erythrophagocytosis and increasing anti-inflammatory mediators while suppressing the production of pro-inflammatory cytokines. Administration of rhCDNF results in upregulation of the Nrf2-HO-1 pathway, but alleviation of oxidative stress and unfolded protein responses in the perihematomal area. Finally, we demonstrate that intravenous delivery of rhCDNF has beneficial effects in an animal model of ICH and that systemic application promotes scavenging by the brain's myeloid cells for the treatment of ICH.Peer reviewe
Finfish and aquatic invertebrate pathology resources for now and the future
Utilization of finfish and aquatic invertebrates in biomedical research and as environmental sentinels has grown dramatically in recent decades. Likewise the aquaculture of finfish and invertebrates has expanded rapidly worldwide as populations of some aquatic food species and threatened or endangered aquatic species have plummeted due to overharvesting or habitat degradation. This increasing intensive culture and use of aquatic species has heightened the importance of maintaining a sophisticated understanding of pathology of various organ systems of these diverse species. Yet, except for selected species long cultivated in aquaculture, pathology databases and the workforce of highly trained pathologists lag behind those available for most laboratory animals and domestic mammalian and avian species. Several factors must change to maximize the use, understanding, and protection of important aquatic species: 1) improvements in databases of abnormalities across species; 2) standardization of diagnostic criteria for proliferative and nonproliferative lesions; and 3) more uniform and rigorous training in aquatic morphologic pathology
Finfish and aquatic invertebrate pathology resources for now and the future
Utilization of finfish and aquatic invertebrates in biomedical research and as environmental sentinels has grown dramatically in recent decades. Likewise the aquaculture of finfish and invertebrates has expanded rapidly worldwide as populations of some aquatic food species and threatened or endangered aquatic species have plummeted due to overharvesting or habitat degradation. This increasing intensive culture and use of aquatic species has heightened the importance of maintaining a sophisticated understanding of pathology of various organ systems of these diverse species. Yet, except for selected species long cultivated in aquaculture, pathology databases and the workforce of highly trained pathologists lag behind those available for most laboratory animals and domestic mammalian and avian species. Several factors must change to maximize the use, understanding, and protection of important aquatic species: 1) improvements in databases of abnormalities across species; 2) standardization of diagnostic criteria for proliferative and nonproliferative lesions; and 3) more uniform and rigorous training in aquatic morphologic pathology
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