Electroweak constraints on new physics

We briefly review the limits on new interactions implied by electroweak precision data. Special attention is payed to the bounds on the Higgs boson mass. We also comment on the required cancellation among the new contributions to precisely measured electroweak observables in any Standard Model extension, if the new particles have to evade the indirect constraints on their couplings and masses but still remain at the LHC reach.Comment: Latex 4 pages, 1 table, 2 figures. To appear in the proceedings of 10th Hellenic School and Workshops on Elementary Particle Physics and Gravity (Corfu 2010), Corfu, Greece, Aug 29 - Sep 19, 201

Higgs Searches at the LHC

These proceedings summarize the sensitivity for the ATLAS and CMS experiments at the LHC to discover a Standard Model Higgs boson with relatively low integrated luminosity per experiment. A brief discussion on the expected performance from these experiments in searches for one or more of the Higgs bosons from the minimal version of the supersymmetric theories is also included.Comment: Contribution to the proceedings of the XLIII Rencontres de Moriond (session devoted to QCD and High Energy Interactions), La Thuile, Italy. 4 pages, 5 figure

Spartan Daily, February 13, 2004

Volume 122, Issue 10https://scholarworks.sjsu.edu/spartandaily/9945/thumbnail.jp

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB. As part of our efforts towards the discovery of new anti-tubercular leads, a number of potent tetrahydropyrazolo[1,5-a]pyrimidine-3-ca​rboxamide(THPP) and N-benzyl-6′,7′-dihydrospiro[piperidine-4,​4′-thieno[3,2-c]pyran](Spiro) analogues were recently identified against Mycobacterium tuberculosis and Mycobacterium bovis BCG through a high-throughput whole-cell screening campaign. Herein, we describe the attractive in vitro and in vivo anti-tubercular profiles of both lead series. The generation of M. tuberculosis spontaneous mutants and subsequent whole genome sequencing of several resistant mutants identified single mutations in the essential mmpL3 gene. This ‘genetic phenotype’ was further confirmed by a ‘chemical phenotype’, whereby M. bovis BCG treated with both the THPP and Spiro series resulted in the accumulation of trehalose monomycolate. In vivo efficacy evaluation of two optimized THPP and Spiro leads showed how the compounds were able to reduce >2 logs bacterial cfu counts in the lungs of infected mice

The Colonelette (November 1982)

On September 22, 1949, Shirley Cupp, Irma Beisel, Frances Stuckey and Mr. Hilary Bufton Jr. met in a coffee shop in downtown Kansas City to incorporate the American Business Women’s Association (ABWA). Jean Fulkerson helped start The Kentucky Colonels Chapter on 3 June 1964 in Bowling Green, Kentucky. Twenty-six women met at Western Hills Restaurant and elected Linda Sidebottom as the first president. Besides providing professional development opportunities for local businesswomen, the Chapter gave scholarships to women furthering their education, and held social and recognition events throughout the year. Their newsletter, “The Colonelette,” was started in June 1964. Also included here are issues of “The Charter” and “ABWA,” which were newsletters for The Bowling Green Charter Chapter of ABWA