Red Runaways: Hypervelocity Stars, Hills Ejecta and Other Outliers in the F-M Star Regime

In this paper we analyze a sample of metal-rich (>-0.8 dex) main sequence stars in the extended solar neighborhood, investigating kinematic outliers from the background population. The data, which are taken from the Sloan Digital Sky Survey, are kinematically profiled as a function of distance from the Galactic plane using full six dimensional phase space information. Each star is examined in the context of these kinematic profiles and likelihoods are assigned to quantify whether a star matches the underlying profile. Since some of these stars are likely to have been ejected from the disc, we trace back their orbits in order to determine potential ejection radii. We find that objects with low probability (i.e. `outliers') are typically more metal poor, faster and, most importantly, have a tendency to originate from the inner Galaxy compared to the underlying population. We also compose a sample of stars with velocities exceeding the local escape velocity. Although we do not discount that our sample could be contaminated by objects with spurious proper motions, a number of stars appear to have been ejected from the disc with exceptionally high velocities. Some of these are consistent with being ejected from the spiral arms and hence are a rich resource for further study. Finally we look at objects whose orbits are consistent with them being ejected at high speeds from the Galactic center. Of these objects we find that one, J135855.65+552538.19, is inconsistent with halo, bulge and disk kinematics and could plausibly have been ejected from the Galactic nucleus via a Hills mechanism.Comment: 17 Pages, 12 Figures, Accepted to A

Simultaneous Assessment of Speech Identification and Spatial Discrimination: A Potential Testing Approach for Bilateral Cochlear Implant Users?

With increasing numbers of children and adults receiving bilateral cochlear implants, there is an urgent need for assessment tools that enable testing of binaural hearing abilities. Current test batteries are either limited in scope or are of an impractical duration for routine testing. Here, we report a behavioral test that enables combined testing of speech identification and spatial discrimination in noise. In this task, multitalker babble was presented from all speakers, and pairs of speech tokens were sequentially presented from two adjacent speakers. Listeners were required to identify both words from a closed set of four possibilities and to determine whether the second token was presented to the left or right of the first. In Experiment 1, normal-hearing adult listeners were tested at 15° intervals throughout the frontal hemifield. Listeners showed highest spatial discrimination performance in and around the frontal midline, with a decline at more eccentric locations. In contrast, speech identification abilities were least accurate near the midline and showed an improvement in performance at more lateral locations. In Experiment 2, normal-hearing listeners were assessed using a restricted range of speaker locations designed to match those found in clinical testing environments. Here, speakers were separated by 15° around the midline and 30° at more lateral locations. This resulted in a similar pattern of behavioral results as in Experiment 1. We conclude, this test offers the potential to assess both spatial discrimination and the ability to use spatial information for unmasking in clinical populations

Observations of the scale-dependent turbulence and evaluation of the flux-gradient relationship for sensible heat for a closed Douglas-fir canopy in very weak wind conditions

Observations of the scale-dependent turbulent fluxes, variances, and the bulk transfer parameterization for sensible heat above, within, and beneath a tall closed Douglas-fir canopy in very weak winds are examined. The daytime sub-canopy vertical velocity spectra exhibit a double-peak structure with peaks at timescales of 0.8 s and 51.2 s. A double-peak structure is also observed in the daytime sub-canopy heat flux co-spectra. The daytime momentum flux co-spectra in the upper bole space and in the sub-canopy are characterized by a relatively large crosswind component, likely due to the extremely light and variable winds, such that the definition of a mean wind direction, and subsequent partitioning of the momentum flux into along- and cross-wind components, has little physical meaning. Positive values of both momentum flux components in the sub-canopy contribute to upward transfer of momentum, consistent with the observed sub-canopy secondary wind speed maximum. For the smallest resolved scales in the canopy at nighttime, we find increasing vertical velocity variance with decreasing timescale, consistent with very small eddies possibly generated by wake shedding from the canopy elements that transport momentum, but not heat. Unusually large values of the velocity aspect ratio within the canopy were observed, consistent with enhanced suppression of the horizontal wind components compared to the vertical by the very dense canopy. The flux–gradient approach for sensible heat flux is found to be valid for the sub-canopy and above-canopy layers when considered separately in spite of the very small fluxes on the order of a few Wm⁻² in the sub-canopy. However, single-source approaches that ignore the canopy fail because they make the heat flux appear to be counter-gradient when in fact it is aligned with the local temperature gradient in both the sub-canopy and above-canopy layers. While sub-canopy Stanton numbers agreed well with values typically reported in the literature, our estimates for the above-canopy Stanton number were much larger, which likely leads to underestimated modeled sensible heat fluxes above dark warm closed canopies

Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture

Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with acupuncture. Potentially relevant reviews were searched through the register of the Cochrane Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and books. To be included articles had to review prospective clinical trials of acupuncture; had to describe review methods explicitly; had to be published; and had to focus on treatment effects. Information on conditions, interventions, methods, results and conclusions was extracted using a pretested form and summarized descriptively. Results From a total of 48 potentially relevant reviews preselected in a screeening process 39 met the inclusion criteria. 22 were on various pain syndromes or rheumatic diseases. Other topics addressed by more than one review were addiction, nausea, asthma and tinnitus. Almost unanimously the reviews state that acupuncture trials include too few patients. Often included trials are heterogeneous regarding patients, interventions and outcome measures, are considered to have insufficient quality and contradictory results. Convincing evidence is available only for postoperative nausea, for which acupuncture appears to be of benefit, and smoking cessation, where acupuncture is no more effective than sham acupuncture. Conclusions A large number of systematic reviews on acupuncture exists. What is most obvious from these reviews is the need for (the funding of) well-designed, larger clinical trials

Space-time extensions II

The global extendibility of smooth causal geodesically incomplete spacetimes is investigated. Denote by $\gamma$ one of the incomplete non-extendible causal geodesics of a causal geodesically incomplete spacetime $(M,g_{ab})$. First, it is shown that it is always possible to select a synchronised family of causal geodesics $\Gamma$ and an open neighbourhood $\mathcal{U}$ of a final segment of $\gamma$ in $M$ such that $\mathcal{U}$ is comprised by members of $\Gamma$, and suitable local coordinates can be defined everywhere on $\mathcal{U}$ provided that $\gamma$ does not terminate either on a tidal force tensor singularity or on a topological singularity. It is also shown that if, in addition, the spacetime, $(M,g_{ab})$, is globally hyperbolic, and the components of the curvature tensor, and its covariant derivatives up to order $k-1$ are bounded on $\mathcal{U}$, and also the line integrals of the components of the $k^{th}$-order covariant derivatives are finite along the members of $\Gamma$---where all the components are meant to be registered with respect to a synchronised frame field on $\mathcal{U}$---then there exists a $C^{k-}$ extension $\Phi: (M,g_{ab}) \rightarrow (\widehat{M},\widehat{g}_{ab})$ so that for each $\bar\gamma\in\Gamma$, which is inextendible in $(M,g_{ab})$, the image, $\Phi\circ\bar\gamma$, is extendible in $(\widehat{M},\widehat{g}_{ab})$. Finally, it is also proved that whenever $\gamma$ does terminate on a topological singularity $(M,g_{ab})$ cannot be generic.Comment: 42 pages, no figures, small changes to match the published versio

Understanding concurrent earcons: applying auditory scene analysis principles to concurrent earcon recognition

Two investigations into the identification of concurrently presented, structured sounds, called earcons were carried out. One of the experiments investigated how varying the number of concurrently presented earcons affected their identification. It was found that varying the number had a significant effect on the proportion of earcons identified. Reducing the number of concurrently presented earcons lead to a general increase in the proportion of presented earcons successfully identified. The second experiment investigated how modifying the earcons and their presentation, using techniques influenced by auditory scene analysis, affected earcon identification. It was found that both modifying the earcons such that each was presented with a unique timbre, and altering their presentation such that there was a 300 ms onset-to-onset time delay between each earcon were found to significantly increase identification. Guidelines were drawn from this work to assist future interface designers when incorporating concurrently presented earcons

TNF-α Differentially Regulates Cell Cycle Genes In Promyelocytic And Granulocytic HL-60/S4 Cells

Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are context dependent and capable of stimulating pathways promoting both cell death and survival. TNF-α treatment has been investigated as part of a combined therapy for acute myeloid leukemia due to its modifying effects on all-trans retinoic acid (ATRA) mediated differentiation into granulocytes. To investigate the interaction between cellular differentiation and TNF-α, we performed RNA-sequencing on two forms of the human HL-60/S4 promyelocytic leukemia cell line treated with TNF-α. The ATRA-differentiated granulocytic form of HL-60/S4 cells had an enhanced transcriptional response to TNF-α treatment compared to the undifferentiated promyelocytes. The observed TNF-α responses included differential expression of cell cycle gene sets, which were generally upregulated in TNF-α treated promyelocytes, and downregulated in TNF-α treated granulocytes. This is consistent with TNF-α induced cell cycle repression in granulocytes and cell cycle progression in promyelocytes. Moreover, we found evidence that TNF-α treatment of granulocytes shifts the transcriptome toward that of a macrophage. We conclude that TNF-α treatment promotes a divergent transcriptional program in promyelocytes and granulocytes. TNF-α promotes cell cycle associated gene expression in promyelocytes. In contrast, TNF-α stimulated granulocytes have reduced cell cycle gene expression, and a macrophage-like transcriptional program

Can processes make relationships work? The Triple Helix between structure and action

This contribution seeks to explore how complex adaptive theory can be applied at the conceptual level to unpack Triple Helix models. We use two cases to examine this issue – the Finnish Strategic Centres for Science, Technology & Innovation (SHOKs) and the Canadian Business-led Networks of Centres of Excellence (BL-NCE). Both types of centres are organisational structures that aspire to be business-led, with a considerable portion of their activities driven by (industrial) users’ interests and requirements. Reflecting on the centres’ activities along three dimensions – knowledge generation, consensus building and innovation – we contend that conceptualising the Triple Helix from a process perspective will improve the dialogue between stakeholders and shareholders