In response to: Anatomy of 18F-GE180, a failed radioligand for the TSPO protein

Purpose!#!Pulmonary hypertension (PH) is characterized by a progressive remodelling of the pulmonary vasculature resulting in right heart failure and eventually death. The serotonin transporter (SERT) may be involved in the pathogenesis of PH in patients with chronic-obstructive pulmonary disease (COPD). This study investigated for the first time the SERT in vivo availability in the lungs of patients with COPD and PH (COPD+PH).!##!Methods!#!SERT availability was assessed using SERT-selective [!##!Results!#![!##!Conclusion!#!By applying

A review of composite product data interoperability and product life-cycle management challenges in the composites industry

A review of composite product data interoperability and product life-cycle management challenges is presented, which addresses “Product Life-cycle Management”, developments in materials. The urgent need for this is illustrated by the life-cycle management issues faced in modern military aircraft, where in-service failure of composite parts is a problem, not just in terms of engineering understanding, but also in terms of the process for managing and maintaining the fleet. A demonstration of the use of ISO 10303-235 for a range of through-life composite product data is reported. The standardization of the digital representation of data can help businesses to automate data processing. With the development of new materials, the requirements for data information models for materials properties are evolving, and standardization drives transparency, improves the efficiency of data analysis, and enhances data accuracy. Current developments in Information Technology, such as big data analytics methodologies, have the potential to be highly transformative

mmf, ein makefile-Generator

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

InnoRegio-Projekt InnTex: Entwicklung neuartiger Absorptionstextilien unter Verwendung von Recyclingmaterialien (Resorp). Teilprojekt 3 Schlussbericht

Available from TIB Hannover: F04B2101 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman

Changes of serotonin transporter (SERT) availability in human obesity prior and 6 month after an integrative treatment approach

Objectives: Central serotonergic systems comprise important neuromodulatory capacity and participate in regulating appetite and satiety, thus contributing to obesogenic mechanism. Especially presynaptic SERT are target structures for modern antidepressants and interventions aiming to reduce weight. The aim of our study was to quantitatively assess SERT availability in obese, non-depressed humans at baseline and following a 6 months integrative treatment program. SERT was compared with changes in body mass index (BMI) as the outcome parameter. This study investigates SERT levels in obese individuals(OB) and normal-weight, healthy control subjects (NW). Methods: Twenty-two OB (BMI 41±5kg/m2, age 38±11yrs, 14♀) and 15 NW (BMI 23±2 kg/m2, age 36±7yrs, 10♀) were investigated prior and after a 6 month of treatment program including diet, physical and psychological intervention by using C-11-DASB and PET. Parametric images of binding potential BPND (MRTM2) were generated from atlas-based analysis of VOI after coregistration with individual 3D MRI data. Results: In OB, BPND and BMI were negatively associated (P<0.05) in the left medial prefrontal cortex (PFC) (R=-0.37), the left dorso-lateral PFC (R=-0.38), the right hippocampus (R=-0.37) and the left amygdala (R=-0.39, p=0.037). All of these regions showed a significant BPND increase after the OB lost weight (delta BMI -1.02±2.1kg/m2). No significant BPND changes over time were found in the NW. Conclusions: Changes of SERT availability in obese are evident in regions thought to be relevant of eating control. Furthermore, correlation between losing weight and higher SERT mainly in the PFC after the 6 month program suggest that the PFC likely has an essential role in feeding behavior modulated by the serotonin system and SERT availability in those brain areas may serve as a predictor for treatment response