595 research outputs found
NIKEL_AMC: Readout electronics for the NIKA2 experiment
The New Iram Kid Arrays-2 (NIKA2) instrument has recently been installed at
the IRAM 30 m telescope. NIKA2 is a state-of-art instrument dedicated to
mm-wave astronomy using microwave kinetic inductance detectors (KID) as
sensors. The three arrays installed in the camera, two at 1.25 mm and one at
2.05 mm, feature a total of 3300 KIDs. To instrument these large array of
detectors, a specifically designed electronics, composed of 20 readout boards
and hosted in three microTCA crates, has been developed. The implemented
solution and the achieved performances are presented in this paper. We find
that multiplexing factors of up to 400 detectors per board can be achieved with
homogeneous performance across boards in real observing conditions, and a
factor of more than 3 decrease in volume with respect to previous generations.Comment: 21 pages; 16 figure
Trigger and readout electronics for the STEREO experiment
The STEREO experiment will search for a sterile neutrino by measuring the
anti-neutrino energy spectrum as a function of the distance from the source,
the ILL nuclear reactor. A dedicated electronic system, hosted in a single
microTCA crate, was designed for this experiment. It performs triggering in two
stages with various selectable conditions, processing and readout via UDP/IPBUS
of 68 photomultiplier signals continuously digitized at 250 MSPS. Additionally,
for detector performance monitoring, the electronics allow on-line calibration
by driving LED synchronously with the data acquisition. This paper describes
the electronics requirements, architecture and the performances achieved.Comment: Topical Workshop on Electronics for Particle Physics (TWEPP) 2015,
Lisboa. 9 pages, 9 figure
Electronics and data acquisition demonstrator for a kinetic inductance camera
A prototype of digital frequency multiplexing electronics allowing the real
time monitoring of kinetic inductance detector (KIDs) arrays for mm-wave
astronomy has been developed. It requires only 2 coaxial cables for
instrumenting a large array. For that, an excitation comb of frequencies is
generated and fed through the detector. The direct frequency synthesis and the
data acquisition relies heavily on a large FPGA using parallelized and
pipelined processing. The prototype can instrument 128 resonators (pixels) over
a bandwidth of 125 MHz. This paper describes the technical solution chosen, the
algorithm used and the results obtained
Technical characteristics of elite youth female soccer match-play: position and age group comparisons between under 14 and under 16 age groups
The purpose of this study was to quantify the technical characteristics of U14 and U16 elite youth female soccer match-play and compare position-specific differences between and within these age groups. A total of 449 match observations from 45 matches were undertaken on 189 players representing Regional Talent Centres in The Football Associationâs Girlsâ England Talent Pathway league. Linear mixed modelling determined position-specific differences for 24 technical and 4 possession-based variables. Results showed similar team possession-based characteristics at both age groups. Interceptions (U14 = 4.6 ± 0.3, U16 = 3.9 ± 0.3) and tackles (U14 = 4.2 ± 0.3, U16 = 3.2 ± 0.3) were the most common defensive actions. Passes were the most common offensive action (U14 = 21.8 ± 1.8, U16 = 25.1 ± 1.9). In possession, U14 central players performed more actions than wide players, whilst actions were more evenly distributed amongst positions at U16, suggesting a variation in playing style between age groups. Technical performances of players were position-dependent, and differences in offensive and defensive variables were observed between age groups across all positions. These findings may assist practitioners in informing specific coaching practice, training programme design or talent identification processes within this population
Effects of Concurrent Resistance and Aerobic Training on Load-Bearing Performance and the Army Physical Fitness Test
The purpose of this research was to determine the effects of high intensity endurance training (ET) and resistance training (RT) alone and in combination on various military tasks. Thirty-five male soldiers were randomly assigned to one of four training groups: total body resistance training plus endurance training (RT + ET), upper body resistance training plus endurance training [UB + ET), RT only, and ET only. Training was performed 4 days per week for 12 weeks. Testing occurred before and after the 12-week training regimen. All groups significantly improved push-up performance, whereas only the RT + ET group did not improve sit-up performance. The groups that included ET significantly decreased 2-mile run time, however, only RT + ET and UB + ET showed improved loaded 2-mile run time. Leg power increased for groups that included lower body strengthening exercises (RT and RT + ET). Army Physical Fitness Test performance, loaded running, and leg power responded positively to training, however, it appears there is a high degree of specificity when concurrent training regimens are implemented
Generation of an induced pluripotent stem cell line, CSSi011-A (6534), from an Amyotrophic lateral sclerosis patient with heterozygous L145F mutation in SOD1 gene
Among the known causative genes of familial ALS, SOD1 mutation is one of the most common. It encodes for the ubiquitous detoxifying copper/zinc binding SOD1 enzyme, whose mutations selectively cause motor neuron death, although the mechanisms are not as yet clear. What is known is that mutant-mediated toxicity is not caused by loss of its detoxifying activity but by a gain-of-function. In order to better understand the pathogenic mechanisms of SOD1 mutation, a human induced pluripotent stem cell (hiPSC) line was generated from the somatic cells of a female patient carrying a missense variation in SOD1 (L145F)
The NIKA2 instrument, a dual-band kilopixel KID array for millimetric astronomy
NIKA2 (New IRAM KID Array 2) is a camera dedicated to millimeter wave
astronomy based upon kilopixel arrays of Kinetic Inductance Detectors (KID).
The pathfinder instrument, NIKA, has already shown state-of-the-art detector
performance. NIKA2 builds upon this experience but goes one step further,
increasing the total pixel count by a factor 10 while maintaining the
same per pixel performance. For the next decade, this camera will be the
resident photometric instrument of the Institut de Radio Astronomie
Millimetrique (IRAM) 30m telescope in Sierra Nevada (Spain). In this paper we
give an overview of the main components of NIKA2, and describe the achieved
detector performance. The camera has been permanently installed at the IRAM 30m
telescope in October 2015. It will be made accessible to the scientific
community at the end of 2016, after a one-year commissioning period. When this
happens, NIKA2 will become a fundamental tool for astronomers worldwide.Comment: Proceedings of the 16th Low Temperature Detectors workshop. To be
published in the Journal of Low Temperature Physics. 8 pages, 4 figures, 1
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Roadmap on Wilson loops in 3d Chern-Simons-matter theories
This is a compact review of recent results on supersymmetric Wilson loops in ABJ(M) and related theories. It aims to be a quick introduction to the state of the art in the field and a discussion of open problems. It is divided into short chapters devoted to different questions and techniques. Some new results, perspectives and speculations are also presented. We hope this might serve as a baseline for further studies of this topic
Known drugs identified by structure-based virtual screening are able to bind sigma-1 receptor and increase growth of huntington disease patient-derived cells
Huntington disease (HD) is a devastating and presently untreatable neurodegenerative disease characterized by progressively disabling motor and mental manifestations. The sigma-1 receptor (Ï1R) is a protein expressed in the central nervous system, whose 3D structure has been recently determined by X-ray crystallography and whose agonists have been shown to have neuro-protective activity in neurodegenerative diseases. To identify therapeutic agents against HD, we have implemented a drug repositioning strategy consisting of: (i) Prediction of the ability of the FDA-approved drugs publicly available through the ZINC database to interact with Ï1R by virtual screening, followed by computational docking and visual examination of the 20 highest scoring drugs; and (ii) Assessment of the ability of the six drugs selected by computational analyses to directly bind purified Ï1R in vitro by Surface Plasmon Resonance and improve the growth of fibro-blasts obtained from HD patients, which is significantly impaired with respect to control cells. All six of the selected drugs proved able to directly bind purified Ï1R in vitro and improve the growth of HD cells from both or one HD patient. These results support the validity of the drug repositioning procedure implemented herein for the identification of new therapeutic tools against HD
Status of the Super-B factory Design
The SuperB international team continues to optimize the design of an
electron-positron collider, which will allow the enhanced study of the origins
of flavor physics. The project combines the best features of a linear collider
(high single-collision luminosity) and a storage-ring collider (high repetition
rate), bringing together all accelerator physics aspects to make a very high
luminosity of 10 cm sec. This asymmetric-energy collider
with a polarized electron beam will produce hundreds of millions of B-mesons at
the (4S) resonance. The present design is based on extremely low
emittance beams colliding at a large Piwinski angle to allow very low
without the need for ultra short bunches. Use of crab-waist
sextupoles will enhance the luminosity, suppressing dangerous resonances and
allowing for a higher beam-beam parameter. The project has flexible beam
parameters, improved dynamic aperture, and spin-rotators in the Low Energy Ring
for longitudinal polarization of the electron beam at the Interaction Point.
Optimized for best colliding-beam performance, the facility may also provide
high-brightness photon beams for synchrotron radiation applications
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