B\,^1\Sigma^{+}_{u} and EF\,^{1}\Sigma^{+}_{g} level energies of D2_{2}

Accurate absolute level energies of the B\,^1\Sigma^{+}_{u}, $v=0-8, N$ and EF\,^{1}\Sigma^{+}_{g}, $v=0-21, N$ rovibrational quantum states of molecular deuterium are derived by combining results from a Doppler-free two-photon laser excitation study on several lines in the $EF\,{}^{1}\Sigma_{g}^{+}-X\,{}^{1}\Sigma_{g}^{+}$ (0,0) band, with results from a Fourier-transform spectroscopic emission study on a low-pressure hydrogen discharge. Level energy uncertainties as low as 0.0005 cm$^{-1}$ are obtained for some low-lying E\,^{1}\Sigma^{+}_{g} inner-well rovibrational levels, while uncertainties for higher-lying rovibrational levels and those of the F\,^{1}\Sigma^{+}_{g} outer-well states are nominally 0.005 cm$^{-1}$. Level energies of B\,^1\Sigma^{+}_{u} rovibrational levels, for $v \leq 8$ and $N \leq 10$ are determined at an accuracy of 0.001 cm$^{-1}$. Computed wavelengths of D$_2$ Lyman transitions in the B\,^1\Sigma^{+}_{u}-X\,^{1}\Sigma^{+}_{g} ($v,0$) bands are also tabulated for future applications.Comment: appears in Journal of Molecular Spectroscopy (2014

Accurate level energies in the EF1S+g, GK1S+g, H1S+g, B1S+u, C1Pu, B'1S+u, D1Pu, I1Pg, J1Dg states of H2

International audienceBy combining results from a Doppler-free two-photon laser excitation study on several lines in the EF1g+ - X1g+ (0,0) band of H2 with results from a Fourier-transform spectroscopic study on a low-pressure discharge in hydrogen, absolute level energies, with respect to the X1g+, v=0, N=0 ground level, could be determined for 547 rovibronically excited states in H2. While for some of the levels in the EF1g+ and B1u+ states the uncertainties are as low as 0.0001 cm-1, the accuracy of other levels is less accurate. The general improvement on the accuracy for the comprehensive data set of level energies is by an order of magnitude with respect to previous measurements. An updated listing of transition wavelengths of the spectral lines in the Lyman and Werner bands is presented, based on combination differences between the presently obtained B1u+ and C1u level energies and those in the X1g+ ground state

HIGH RESOLUTION FAR INFRARED FOURIER TRANSFORM SPECTROSCOPY OF THE NH2_2 RADICAL.

Author Institution: SOLEIL Synchrotron, AILES beamline, Saint-Aubin, France and Institut des Sciences Moleculaires d'Orsay, ISMO, CNRS, Universite Paris XI, Orsay, France; SOLEIL Synchrotron, AILES beamline, Saint-Aubin, FranceFirst identified toward Sgr B2}, the NH$_2$ radical has recently been detected in the interstellar medium by the HIFI instrument on board of Herschel}. Despite the fact that this radical has not been detected in brown dwarfs and exoplanets yet, it is already included in physical and chemical models of those environments} (temperature higher than 2000 K expected in several objects). Its detection in those objects will depend on the existence of a reliable high temperature and high resolution spectroscopic database on the NH$_2$ radical.The absorption spectrum of NH$_2$ has been recorded between 15 and 700 cm$^{-1}$ at the highest resolution available using the Bruker IFS125HR Fourier transform interferometer connected to the far infrared AILES beamline at SOLEIL (R=0.001~cm$^{-1}$). The radical was produced by an electrical discharge (DC) through a continuous flow of NH$_3$ and He using the White-type discharge cell developped on the beamline (optical path: 24m). Thanks to the brilliance of the synchrotron radiation, more than 700 pure rotational transitions of NH$_2$ have been identified with high N values (N$_{max}$=25) in its fundamental and first excited vibrational modes. By comparison to the previous FT spectroscopic study on that radical in the FIR spectral range}, asymmetric splitting as well as fine and hyperfine structure have been resolved for several transitions

Self‐reported drug allergy in a general adult Portuguese population

Clin Exp Allergy. 2004 Oct;34(10):1597-601. Self-reported drug allergy in a general adult Portuguese population. Gomes E, Cardoso MF, Praça F, Gomes L, Mariño E, Demoly P. Serviço de Imunoalergologia, Hospital Maria Pia, Porto, Portugal. [email protected] Abstract AIM: To estimate the prevalence of self-reported drug allergy in adults. METHODS: Cross-sectional survey of a general adult population from Porto (all of whom were living with children involved in the International Study of Asthma and Allergies in Childhood-phase three), during the year 2002, using a self-administered questionnaire. RESULTS: The prevalence of self-reported drug allergy was 7.8% (181/2309): 4.5% to penicillins or other beta-lactams, 1.9% to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and 1.5% to other drugs. In the group 'allergic to beta-lactams', the most frequently implicated drug was penicillin G or V (76.2%) followed by the association of amoxicillin and clavulanic acids (14.3%). In the group 'allergic to NSAIDs', acetylsalicylic acid (18.2%) and ibuprofen (18.2%) were the most frequently identified drugs, followed by nimesulide and meloxicam. Identification of the exact name of the involved drug was possible in less than one-third of the patients, more often within the NSAID group (59.5%). Women were significantly more likely to claim a drug allergy than men (10.2% vs. 5.3%). The most common manifestations were cutaneous (63.5%), followed by cardiovascular symptoms (35.9%). Most of the reactions were immediate, occurring on the first day of treatment (78.5%). Only half of the patients were submitted to drug allergy investigations. The majority (86.8%) completely avoided the suspected culprit drug thereafter. CONCLUSIONS: The results showed that self-reported allergy to drugs is highly prevalent and poorly explored. Women seem to be more susceptible. beta-lactams and NSAIDs are the most frequently concerned drugs. PMID: 15479276 [PubMed - indexed for MEDLINE

On reminder effects, drop-outs and dominance: evidence from an online experiment on charitable giving

We present the results of an experiment that (a) shows the usefulness of screening out drop-outs and (b) tests whether different methods of payment and reminder intervals affect charitable giving. Following a lab session, participants could make online donations to charity for a total duration of three months. Our procedure justifying the exclusion of drop-outs consists in requiring participants to collect payments in person flexibly and as known in advance and as highlighted to them later. Our interpretation is that participants who failed to collect their positive payments under these circumstances are likely not to satisfy dominance. If we restrict the sample to subjects who did not drop out, but not otherwise, reminders significantly increase the overall amount of charitable giving. We also find that weekly reminders are no more effective than monthly reminders in increasing charitable giving, and that, in our three months duration experiment, standing orders do not increase giving relative to one-off donations

Improved Laboratory Values of the H-2 Lyman and Werner Lines for Constraining Time Variation of the Proton-to-Electron Mass Ratio

Two distinct high-accuracy laboratory spectroscopic investigations of the H-2 molecule are reported. Anchor lines in the EF1 Sigma(+)(g)-X-1 Sigma(+)(g) system are calibrated by two-photon deep-UV Doppler-free spectroscopy, while independent Fourier-transform spectroscopic measurements are performed that yield accurate spacings in the B-1 Sigma(+)(u)-EF1 Sigma(+)(g) and I-1 Pi(g)-C-1 Pi(u) systems. From combination differences accurate transition wavelengths for the B-X Lyman and the C-X Werner lines can be determined with accuracies better than similar to 5x10(-9), representing a major improvement over existing values. This metrology provides a practically exact database to extract a possible variation of the proton-to-electron mass ratio based on H-2 lines in high-redshift objects. Moreover, it forms a rationale for equipping a future class of telescopes, carrying 30-40 m dishes, with novel spectrometers of higher resolving powers

Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?

The concept of chronic kidney disease-mineral bone disorder (CKD-MBD) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benefits for clinicians and patients, including wider and more complex diagnostic and therapeutic approaches to the management of this challenging set of issues. Admittedly, not all components of CKD-MBD are present in all patients at all times, but these are highly interrelated, involving mineral and bone laboratory abnormalities, clinical and histological bone disease and finally, cardiovascular disease. The presence of typical biological bone ossification processes in an ectopic anatomical location in CKD has helped to define the existence of an unprecedented bone-vascular relationship, extending its interest even to other medical specialities. For now, we believe that CKD-MBD does not reach full criteria to be defined as a syndrome. However, this novel concept has clearly influenced current clinical guidelines. The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF/KDOQI\u2122) guidelines in 2003 for instance recommended that calcium-based phosphate binders should be avoided to treat hyperphosphataemia in the presence of cardiovascular calcifications. In 2009, the KDIGO and other guidelines reinforced and extended this recommendation by stating that it is reasonable to choose oral phosphate binder therapy by taking into consideration other components of CKD-MBD. Similarly, it is also considered reasonable to use information on vascular/valvular calcification to guide the management of CKD-MBD. Our current assumption as a working group 'CKD-MBD' is that CKD-MBD has the potential to be defined a true syndrome, such as a constellation of concurrent signs and symptoms that suggest a common underlying mechanism for these components as opposed to the term disease. The term 'syndrome' also implies that in any patient at risk due to the presence of one or a few components of the entire syndrome, the screening for additional components is highly recommended. However, it has not currently been demonstrated that there is an additive predictive value, which can be derived from identifying individual components. Despite all we have learned about this putative syndrome, we have been left with only a hypothetical framework about how to treat patients. So while we agree that the concept of CKD-MBD has influenced, and continues to influence, our current clinical hypotheses, definitive proof of a benefit of interventions in CKD-MBD is still lacking and a global-multiple therapeutic approach to treat simultaneously several components of CKD-MBD should be tested by well-designed new randomized controlled trials