The Local Interstellar Spectrum of Cosmic Ray Electrons

The direct measurements of electrons and positrons over the last 30 years, corrected for the solar effect in the force-field approximation, are considered. The resulting overall electron spectrum may be fitted with a single power law above few GeV with spectral index ($\gamma_{-} = 3.41 \pm 0.02$), consistent with the spectral index of the positron spectrum ($\gamma_{+} = 3.40 \pm 0.06$), therefore suggesting a common acceleration process for both species. We propose that the engine was a shock wave originating from the last supernova explosion among those that formed the local bubble. In addition, at low energy, the electron spectrum measured during the last $A+$ solar phase is damped, whereas the positron spectrum is well represented by a single power law down to the lowest inferred local interstellar energy (0.8 GeV). We suggest that this difference arises from a time- and charge-dependent effect of the solar modulation that is not taken into account by the force-field approximation.Comment: 10 pages, 9 figures, 1 table. OBSOLETE: please refer to ApJ 612 (2004) 262-267, that is the final version of this wor

Haleakala neutron monitor redeployment and calibration with AMS data

Since the 1950s, neutron monitors (NMs) have successfully measured both the long-term and the short-term variation of Galactic Cosmic Rays (GCRs). NMs are also sensitive to solar energetic particles (SEPs) and solar neutron particles (SNPs), both detected as ground level enhancements. Since SNPs are not affected by the interplanetary magnetic field, they retain direct information about the nuclear reactions happening near the SEP acceleration site. The global NM network has still a huge gap over the equatorial Pacific for measuring high energy GCRs and SNPs which are best measured at low latitudes. We plan to extend the coverage of the world wide NM network for SNP and GCR observations by redeploying the Haleakala NM station (HLEA) on Maui, in time for the upcoming solar maximum (around 2025). Since NMs can only measure the total count rate, it is not trivial to derive the actual particle flux and to compare different station responses. We plan to calibrate the HLEA with the future AMS daily proton fluxes, extended until the ISS decommission date now planned in 2031, and to perform extensive Mote Carlo simulations of the detector and surrounding environment. The initial phase of the project has already started. Status of the upcoming HLEA NM detector is reported

Galactic Cosmic Rays Throughout the Heliosphere and in the Very Local Interstellar Medium

We review recent observations and modeling developments on the subject of galactic cosmic rays through the heliosphere and in the Very Local Interstellar Medium, emphasizing knowledge that has accumulated over the past decade. We begin by highlighting key measurements of cosmic-ray spectra by Voyager, PAMELA, and AMS and discuss advances in global models of solar modulation. Next, we survey recent works related to large-scale, long-term spatial and temporal variations of cosmic rays in different regimes of the solar wind. Then we highlight new discoveries from beyond the heliopause and link these to the short-term evolution of transients caused by solar activity. Lastly, we visit new results that yield interesting insights from a broader astrophysical perspective

The TOF counters of the AMS-02 experiment: space qualification tests and beam test results

The scintillator counters of the TOF system of AMS-02 is beeing constructed to match the needs of the AMS-02 experiment that is armed by a high aperture superconducting dipole magnet. The goals of the TOF-02 hodoscopes actually are: to give the fast trigger to the all sub-detectors of AMS-02; to measure the particle velocity ensuring a 1 × 10 9 albedo rejection; to measure the absolute charge by particle energy loss, up to at least Z = 20 . In spring of 2005 all the TOF counter planes will be assembled and the space qualification tests will be performed. A description of the first test results and of the TOF performances will be given

Cooperation beyond development. Rethinking international aid for the self- determination of recipient communities.

Questo articolo propone un dibattito critico e costruttivo sui temi della cooperazione negli ambienti stessi della cooperazione, soprattutto sugli obiettivi reali e apparenti, sugli effetti sortiti inconsapevolmente, e sui vincitori e vinti dell’aiuto internazionale, il tutto visto da una prospettiva socio-economica mondiale. Sono qui presentati i primi esiti di un Seminario Partecipativo tenuto proprio su tali tematiche, articolato in quattro tavoli di lavoro: autodeterminazione e reciprocità, emergenza e sviluppo, formazione, co-progettazione / progettazione partecipata.A critical and constructive debate is proposed on and inside cooperation, specifically on the real and the apparent goals, on the unaware effects, and on the winners and losers of international aid, framed in a global socio-economic perspective. The first outcomes of a recent participatory workshop on such themes are hereby illustrated, divided in four working tables: self-determination and reciprocity, emergency and development, training, and co-design / participatory design

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients