Direct Application of the Phase Estimation Algorithm to Find the Eigenvalues of the Hamiltonians

The eigenvalue of a Hamiltonian, $\mathcal{H}$, can be estimated through the phase estimation algorithm given the matrix exponential of the Hamiltonian, $exp(-i\mathcal{H})$. The difficulty of this exponentiation impedes the applications of the phase estimation algorithm particularly when $\mathcal{H}$ is composed of non-commuting terms. In this paper, we present a method to use the Hamiltonian matrix directly in the phase estimation algorithm by using an ancilla based framework: In this framework, we also show how to find the power of the Hamiltonian matrix-which is necessary in the phase estimation algorithm-through the successive applications. This may eliminate the necessity of matrix exponential for the phase estimation algorithm and therefore provide an efficient way to estimate the eigenvalues of particular Hamiltonians. The classical and quantum algorithmic complexities of the framework are analyzed for the Hamiltonians which can be written as a sum of simple unitary matrices and shown that a Hamiltonian of order $2^n$ written as a sum of $L$ number of simple terms can be used in the phase estimation algorithm with $(n+1+logL)$ number of qubits and $O(2^anL)$ number of quantum operations, where $a$ is the number of iterations in the phase estimation. In addition, we use the Hamiltonian of the hydrogen molecule as an example system and present the simulation results for finding its ground state energy.Comment: 10 pages, 3 figure

Trabalhando com Estatística no ensino remoto com crianças da Educação Especial

Diante do momento pandêmico da COVID-19 que estamos vivendo, optamos por relatar uma proposta envolvendo a Estatística realizada de forma remota com crianças de 5 a 14 anos com desenvolvimento atípico, público-alvo da Educação Especial. A atividade foi desenvolvida em etapas e, depois de analisada, desenvolvemos um gráfico para trabalhar com os estudantes. Concluímos que esse público-alvo precisa de uma melhor preparação a fim de desenvolver certas habilidades necessárias para a compreensão do assunto, mas, de maneira geral, a atividade proposta se mostrou muito efetiva para a introdução da Estatística.   &nbsp

Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy: Aspects of Interest in Clinical Obstetrics

The purpose of this study was to review the literature regarding the action of the cytokines interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnancy and to emphasize the factors that are of interest to clinical obstetrics. The literature highlights several actions of IL-10 and TNF-α during pregnancy. The actions of these cytokines seem to be antagonistic and dependent on the balance between them, which is orchestrated by the specific immunosuppressive action of IL-10. TNF-α has a characteristic inflammatory action, and it is an additional diabetogenic factor in pregnancy. The loss of the control of the production of these cytokines, with increase of TNF-α, is related to the risk for developing obstetric complications, particularly recurrent fetal loss, gestational diabetes mellitus, hypertensive syndromes, and fetal growth restriction. However, study results are controversial and are not clearly defined. These issues are attributed to the heterogeneity of the studies, particularly regarding their sample sizes and sources, the evaluation methods, and the multiplicity of factors and conditions that influence cytokine production. These questions are fundamental and should be addressed in future investigations to obtain more consistent results that can be applied to obstetric practice

Trabalhando com Estatística no ensino remoto com crianças da Educação Especial

Diante do momento pandêmico da COVID-19 que estamos vivendo, optamos por relatar uma proposta envolvendo a Estatística realizada de forma remota com crianças de 5 a 14 anos com desenvolvimento atípico, público-alvo da Educação Especial. A atividade foi desenvolvida em etapas e, depois de analisada, desenvolvemos um gráfico para trabalhar com os estudantes. Concluímos que esse público-alvo precisa de uma melhor preparação a fim de desenvolver certas habilidades necessárias para a compreensão do assunto, mas, de maneira geral, a atividade proposta se mostrou muito efetiva para a introdução da Estatística.   &nbsp

Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential

The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and "omics" sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent "boom" in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.74CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESSem informação88881.134095/2016-01; 8881.134512/2016-0

Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential

Made available in DSpace on 2019-10-06T16:24:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2019-10-09T18:35:21Z : No. of bitstreams: 1 S1807-59322019000100303.pdf: 766293 bytes, checksum: d3694a392a2120b7b8d5e91ffe93d3f0 (MD5)The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and “omics” sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent “boom” in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.Departamento de Ginecologia e Obstetricia Faculdade de Ciencias Medicas Universidade Estadual de CampinasDepartamento Materno Infantil Faculdade de Medicina Universidade Federal de PernambucoDepartamento de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu Universidade Estadual de Sao Paulo (UNESP)Departamento de Ginecologia e Obstetricia Faculdade de Medicina Universidade Federal do Rio Grande do SulDepartamento de Ginecologia e Obstetricia Faculdade de Medicina Universidade Federal do CearaUniversity of LeicesterUniversity of CorkGravida: National Center for Growth & Development Liggins Institute University of AucklandSchool of Medical Sciences University of CampinasLNBioDepartment of Mother and Child Health School of Medicine Federal University of PernambucoSchool of Medicine of Botucatu UNESPHospital de Clínicas de Porto Alegre and School of Medicine Federal University of Rio Grande do SulSchool of Medicine Federal University of CearaDepartamento de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu Universidade Estadual de Sao Paulo (UNESP)School of Medicine of Botucatu UNES

Schizophrenic urban reality: the changing urban landscapes of the Mediterranean region and developmental influences

This chapter considers aspects of urban design and associated identity of place that shifts over time and has to identify with aspects of economic pressures to develop as well as cultural concerns about change

Viabilidade econômica de três miniusinas para produção de biodiesel utilizando como matéria prima o óleo de crambe (Crambe Abyssinica Hochst)

This paper aimed at performing a study to identify, through economic indicators, the best settings for thr ee different production models of biodiese l miniplants, producing 44, 66 e 110 L. h - 1 . The study used cost rates of Cramble oil ( Crambe abyssinica Hochst ) as feddstock for biodiesel production. Methodology showed facilities description as well as determinin g and quantifying costs and incomes. Finally, economical viability analysis was carried out using the method of Net Present Value (NPV), return internal rate ( T IR) and payback discounted . After economic indicator analysis it was observed the viability for 66 and 110 L. h - 1 biodiesel miniplants implantationO objetivo deste trabalho f oi realiza r um estudo para identificar por meio de indicadores econômicos as melhores configurações entre três diferentes modelos produtivos de mini usinas produtora s de biodiesel com ca pacidade de produção de 44, 66 e 110 L. h - 1 . E ste trabalho utilizou os valores referent es ao custo do óleo da cultura de Crambe ( Crambe abyssinica Hochst ) como matéria prima para produção de biodiesel . A metodologia utilizada foi demonstrar uma descrição das in stalações, a discriminação e a quantificação de todos os custos e receitas, e fina lmente realizar uma análise dos indicativos de viabilidade econômica, utilizando o método d o V alor Presente Líquido (VPL), a Taxa I nterna de R etorno (TIR) e o P ayback descontado. Após a análise dos indicadores de viabilidade econômica pode - se constatar que é viável a implantação das miniusinas de 66 e 110 L.h -