The effective elastic thickness of the India Plate from receiver function imaging, gravity anomalies and thermomechanical modelling

The range and the meaning of the effective elastic thickness (EET) in continental areas have been subject to controversy over the last two decades. Here we take advantage of the new data set from the Hi-CLIMB seismological experiment to re-estimate the EET of the India Plate along a south-north profile extending from the Ganges basin to central Tibet. Receiver functions give a high-resolution image of the base of the foreland basin at similar to 5 km depth and constrain the crustal thickness, which increases northwards from similar to 35 km beneath the indo-gangetic plain to similar to 70 km in southern Tibet. Together with available data sets including seismic profiles, seismological images from both INDEPTH and HIMNT experiments, deep well measurements and Bouguer anomaly profiles, we interpret this new image with 2-D thermomechanical modelling solutions, using different type of crustal and mantle rheologies. We find that (1) the EET of the India Plate decreases northwards from 60-80 to 20-30 km as it is flexed down beneath Himalaya and Tibet, due to thermal and flexural weakening; (2) the only resistant layer of the India Plate beneath southern Tibet is the upper mantle, which serves as a support for the topographic load and (3) the most abrupt drop in the EET, located around 200 km south of the MFT, is associated with a gradual decoupling between the crust and the mantle. We show that our geometrical constraints do not allow to determine if the upper and lower crust are coupled or not. Our results clearly reveal that a rheology with a weak mantle is unable to explain the geometry of the lithosphere in this region, and they are in favour of a rheology in which the mantle is strong

Experimental pig-to-pig transmission dynamics for African swine fever virus, Georgia 2007/1 strain

African swine fever virus (ASFV) continues to cause outbreaks in domestic pigs and wild boar in Eastern European countries. To gain insights into its transmission dynamics, we estimated the pig-to-pig basic reproduction number (R 0) for the Georgia 2007/1 ASFV strain using a stochastic susceptible-exposed-infectious-recovered (SEIR) model with parameters estimated from transmission experiments. Models showed that R 0 is 2·8 [95% confidence interval (CI) 1·3–4·8] within a pen and 1·4 (95% CI 0·6–2·4) between pens. The results furthermore suggest that ASFV genome detection in oronasal samples is an effective diagnostic tool for early detection of infection. This study provides quantitative information on transmission parameters for ASFV in domestic pigs, which are required to more effectively assess the potential impact of strategies for the control of between-farm epidemic spread in European countries.ISSN:0950-2688ISSN:1469-440

Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression

In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a selective COX-2 inhibitor, provoked a large decrease in diosgenin-induced apoptosis even in the presence of exogenous prostaglandin E(2), whereas interleukin-1β, a COX-2 inducer, strongly increased diosgenin-induced apoptosis of these synoviocytes. These findings suggest that the proapoptotic effect of diosgenin is associated with overexpression of COX-2 correlated with overproduction of endogenous prostaglandin E(2). We also observed a loss of mitochondrial membrane potential, caspase-3 activation, and DNA fragmentation after diosgenin treatment

The 2015 Gorkha earthquake: A large event illuminating the Main Himalayan Thrust fault

International audienceThe 2015 Gorkha earthquake sequence provides an outstanding opportunity to better characterize the geometry of the Main Himalayan Thrust (MHT). To overcome limitations due to unaccounted lateral heterogeneities, we perform Centroid Moment Tensor inversions in a 3-D Earth model for the main shock and largest aftershocks. In parallel, we recompute S-toP and P-to-S receiver functions from the Hi-CLIMB data set. Inverted centroid locations fall within a low-velocity zone at 10–15 km depth and corresponding to the subhorizontal portion of the MHT that ruptured during the Gorkha earthquake. North of the main shock hypocenter, receiver functions indicate a north dipping feature that likely corresponds to the midcrustal ramp connecting the flat portion to the deep part of the MHT. Our analysis of the main shock indicates that long-period energy emanated updip of high-frequency radiation sources previously inferred. This frequency-dependent rupture process might be explained by different factors such as fault geometry and the presence of fluids

Preformed expression of defense is a hallmark of partial resistance to rice blast fungal pathogen Magnaporthe oryzae

Background: Partial resistance to plant pathogens is extensively used in breeding programs since it could contribute to resistance durability. Partial resistance often builds up during plant development and confers quantitative and usually broad-spectrum resistance. However, very little is known on the mechanisms underlying partial resistance. Partial resistance is often explained by poorly effective induction of plant defense systems. By exploring rice natural diversity, we asked whether expression of defense systems before infection could explain partial resistance towards the major fungal pathogen Magnaporthe oryzae. The constitutive expression of 21 defense-related genes belonging to the defense system was monitored in 23 randomly sampled rice cultivars for which partial resistance was measured. Results: We identified a strong correlation between the expression of defense-related genes before infection and partial resistance. Only a weak correlation was found between the induction of defense genes and partial resistance. Increasing constitutive expression of defense-related genes also correlated with the establishment of partial resistance during plant development. Some rice genetic sub-groups displayed a particular pattern of constitutive expression, suggesting a strong natural polymorphism for constitutive expression of defense. Constitutive levels of hormones like salicylic acid and ethylene cannot explain constitutive expression of defense. We could identify an area of the genome that contributes to explain both preformed defense and partial resistance. Conclusion: These results indicate that constitutive expression of defense-related genes is likely responsible for a large part of partial resistance in rice. The finding of this preformed defense system should help guide future breeding programs and open the possibility to identify the molecular mechanisms behind partial resistance. ( Résumé d'auteur

Invariants of solvable rigid Lie algebras up to dimension 8

The invariants of all complex solvable rigid Lie algebras up to dimension eight are computed. Moreover we show, for rank one solvable algebras, some criteria to deduce to non-existence of non-trivial invariants or the existence of fundamental sets of invariants formed by rational functions of the Casimir invariants of the associated nilradical.Comment: 16 pages, 7 table

Spatiotemporal sequence of Himalayan debris flow from analysis of high-frequence seismic noise

During the 2003 summer monsoon, the Hi‐CLIMB seismological stations deployed across the Himalayan Range detected bursts of high‐frequency seismic noise that lasted several hours to days. On the basis of the cross correlation of seismic envelopes recorded at 11 stations, we show that the largest transient event on 15 August was located nearby a village partially destroyed on that day by a devastating debris flow. This consistency in both space and time suggests that high‐frequency seismic noise analysis can be used to monitor debris flow generation as well as the evacuation of the sediment. A systematic study of one year of seismic noise, focusing on the detection of similar events, provides information on the spatial and temporal occurrence of mass movements at the front of the Himalayas. With a 50% probability of occurrence of a daily event, a total of 46 debris flows are seismically detected. Most of them were generated in regions of steep slopes, large gullies, and loose soils during the 2003 summer monsoon storms. These events are compared to local meteorological data to determine rainfall thresholds for slope failures, including the cumulative rainfall needed to bring the soil moisture content to failure capacity. The inferred thresholds are consistent with previous estimates deduced from soil studies as well as sediment supply investigations in the area. These results point out the potential of using seismic noise as a dedicated tool for monitoring the spatiotemporal occurrence of landslides and debris flows on a regional scale

Spectral analysis of seismic noise induced by rivers: a new tool to monitor spatiotemporal changes in stream hydrodynamics

Analysis of continuous seismic data recorded by a dense passive seismological network (Hi‐CLIMB) installed across the Himalayas reveals strong spatial and temporal variations in the ambient seismic energy produced at high frequencies (>1 Hz). From June to September 2003, the high‐frequency seismic noise is observed to increase up to 20 dB (relative to (m/s)²/Hz) for all the stations located along a steep 30‐km‐long narrow and deeply incised channel of the Trisuli River, a major trans‐Himalayan river. The early summer increase in high‐frequency energy is modulated by a 24‐h periodicity where the minimum of seismic noise level is reached around noon and the maximum is reached late in the evening. A detailed study of seismic noise amplitude reveals a clear correlation with both regional meteorological and hydrological data along the Trisuli River. Seasonal increase in ambient noise coincides with the strong monsoon rainfall and a period of rapid melting of snow and ice in the high elevations. The observed 24‐h cyclicity is consistent with the daily fluctuation of the precipitation and river discharge in the region. River‐induced seismic noise is partly generated by stream turbulence, but this mechanism fails to explain the observed clockwise hysteresis of seismic noise amplitude versus water level. This pattern is better explained if a significant part of the observed seismic noise is caused by ground vibrations generated by bed load transport. This points out the potential of using background seismic noise to quantify in continuous river bed load and monitor its spatial variations, which remain difficult with classical approaches