Antioxidant Capacity of Cotyledons and Germs of Soybeanb in Relation to Their Isoflavone Content

Svrha je ovog istraživanja bila proučiti odnos antioksidativnog kapaciteta i udjela izoflavona u ekstraktu soje s obzirom na geografsko podrijetlo i kultivar. Uzorci soje uzeti su iz dva dijela zrna soje, klice i kotiledona, s dvaju zemljopisnih lokacija (L1 i L2) i iz dva kultivara (Queen i Imari), ukupno 8 različitih uzoraka. HPLC metoda potvrdila je veći udio izoflavona u klicama nego u kotiledonima, i to u uzorcima s lokacije L2 i u kultivaru Queen. Antioksidativni kapacitet uzoraka soje određen je dvjema metodama, uklanjanjem 2,2\u27- difenil-1-pikrilhidrazil radikala i određivanjem sposobnosti apsorpcije kisikovih radikala. Rezultati obiju metoda pokazali su veću antioksidativnu aktivnost ekstrakta klice od ekstrakta kotiledona.The aim was to study the relationship between the antioxidant capacity and the isoflavone content of soybean extracts depending on both geographic origin and cultivar. Soybean samples were obtained from two soybean seed parts, germ and cotyledon, from two geographical locations (L1, L2) and two cultivars (Queen, Imari), which gave 8 different samples. HPLC determination confirmed higher isoflavone content in germs than in cotyledons, with higher contents in site L2, and in the Queen cultivar. The antioxidant capacity of soybean samples was determined with two methods, the 2,2-diphenyl-1-picrylhydrazyl scavenging assay and the oxygen radical absorbance capacity assay. The results obtained with both assays showed differences in antioxidant capacity between germ and cotyledon extracts, with a higher antioxidant activity of germ extracts

Psychiatric and cognitive phenotype in children and adolescents with myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is the most frequent inherited neuromuscular disorder. The juvenile form has been associated with cognitive and psychiatric dysfunction, but the phenotype remains unclear. We reviewed the literature to examine the psychiatric phenotype of juvenile DM1 and performed an admixture analysis of the IQ distribution of our own patients, as we hypothesised a bimodal distribution. Two-thirds of the patients had at least one DSM-IV diagnosis, mainly attention deficit/ hyperactivity disorder and anxiety disorder. Two-thirds had learning disabilities comorbid with mental retardation on one hand, but also attention deficit, low cognitive speed and visual spatial impairment on the other. IQ showed a bi-modal distribution and was associated with parental transmission. The psychiatric phenotype in juvenile DM1 is complex. We distinguished two different phenotypic subtypes: one group characterised by mental retardation, severe developmental delay and maternal transmission; and another group characterised by borderline full scale IQ, subnormal development and paternal transmission

L'enseignement du français en Russie : état des lieux et perspectives

Roos Hélène, Verger Jean-Marie. L'enseignement du français en Russie : état des lieux et perspectives. In: Cahiers de l'Association internationale des études francaises, 2000, n°52. pp. 23-30

L'intérêt de la télédétection pour le monitorage des eaux de la Méditerranée et de ses rivages

International audienceCette conférence aborde les différents domaines où la télédétection est d'un apport prouvé

HREM image simulations of cubic approximant and icosahedral Al-Li-Cu phases (Poster)

International audienc

AFSIW Y-junction Circulator for High-power Handling New Space Applications

In this paper, a novel patent pending air-filled substrate integrated waveguide (AFSIW) Y-junction circulator topology intended for high-power handling space applications is presented. This new device has been developed to pave the way for future implementation of compact high-power microwave systems on substrate (SoS) based on the low-cost and high-performance AFSIW technological platform. This new circulator structure takes advantage of the AFSIW multilayer feature. It is not based on any impedance matching metal post or dielectric spacer. Instead, for matching purposes, the AFSIW top substrate material is used to load a full-height ferrite loaded Y-junction. This simple arrangement provides ease of manufacturing together with a high continuous wave (CW) and multipactor power handling capability, as the ferrite surface can be increased thank to sufficient design latitude and no gap is involved, respectively. For experimental validation, a demonstrator operating at 18.65 GHz, within the satellite downlink Ka-band, is designed and manufactured. It achieves a return loss, transmission loss, isolation and multipactor power handling in a fault short-circuited configuration of 20 dB, 0.68 dB, 21 dB and better than 200 W, respectively

Dissolved organic matter from treated effluent of a major wastewater treatment plant: characterization and influence on copper toxicity.

International audienceA combination of reverse osmosis (RO) concentration and DAX-8/XAD-4 resin adsorption techniques is used to isolate the various constituents of urban dissolved organic matter (DOM) from inorganic salts. Three fractions: hydrophobic (HPO), transphilic (TPI) and hydrophilic (HPI) accounting respectively for 35%, 20% and 45% of extracted carbon, are isolated from effluents of a major French wastewater treatment plant. This atypical DOC distribution, in comparison with natural water where the HPO fraction dominates, shows the significance of HPI fraction which often gets neglected because of extraction difficulties. A number of analytical techniques (elemental, spectroscopic: UV, FTIR) allow highlighting the weak aromaticity of wastewater effluent DOM (EfOM) due to fewer degradation and condensation processes and the strong presence of proteinaceous structures indicative of intense microbial activity. Copper toxicity in the presence of DOM is estimated using an acute toxicity test on Daphnia Magna (Strauss). Results reveal the similar protective role of each EfOM fraction compared to reference Suwannee river fulvic acid despite lower EfOM aromaticity (i.e. specific UV absorbance). The environmental implications of these results are discussed with respect to the development of site-specific water quality criteria

Brain metabolism and related connectivity in patients with acrophobia treated by virtual reality therapy: an F-18-FDG PET pilot study sensitized by virtual exposure

International audienceBackground: The aim of this pilot study is to investigate the impact of virtual reality exposure therapy (VRET) on brain metabolism and connectivity. Eighteen patients with acrophobia were assessed by an F-18-FDG PET scan sensitized by virtual exposure before treatment, and nine of them were assessed again after eight sessions of VRET. Statistical Parametric Mapping was used to study the correlations between metabolism and pretherapeutic clinical scores and to compare metabolism before and after VRET (p voxel < 0.005, corrected for cluster volume). Metabolic connectivity was evaluated through interregional correlation analysis. Results: Before therapy, a positive correlation was found between scores on the behavioural avoidance test and left occipital metabolism (BA17-18). After VRET, patients presented increased metabolism in the left frontal superior gyri and the left precentral gyrus, which showed increased metabolic connectivity with bilateral occipital areas (BA17-18-19), concomitant with clinical recovery. Conclusions: This study highlights the exciting opportunity to use brain PET imaging to investigate metabolism during virtual exposure and reports the involvement of the visual-motor control system in the treatment of acrophobia by VRET

Adult diffuse low-grade gliomas: 35-year experience at the Nancy France neurooncology unit

International audienceBackground: To report survival, spontaneous prognostic factors, and treatment efficacy in a French monocentric cohort of diffuse low-grade glioma (DLGG) patients over 35 years of follow-up.Methods: A monocentric retrospective study of 339 patients diagnosed with a new DLGG between 01/01/1982 and 01/01/2017 was created. Inclusion criteria were patient age ≥18 years at diagnosis and histological diagnosis of WHO grade II glioma (according to 1993, 2007, and 2016 WHO classifications). The survival parameters were estimated using the Kaplan-Meier method with a 95% confidence interval. Differences in survival were tested for statistical significance by the log-rank test. Factors were considered significant when p ≤ 0.1 and p ≤ 0.05 in the univariate and multivariate analyses, respectively.Results: A total of 339 patients were included with a median follow-up of 8.7 years. The Kaplan-Meier median overall survival was 15.7 years. At the time of radiological diagnosis, Karnofsky Performance Status score and initial tumor volume were significant independent prognostic factors. Oncological prognostic factors were the extent of resection for patients who underwent surgery and the timing of radiotherapy for those concerned. In this study, patients who had delayed radiotherapy (provided remaining low grade) did not have worse survival compared with patients who had early radiotherapy. The functional capabilities of the patients were preserved enough so that they could remain independent during at least three quarters of the follow-up.Conclusion: This large monocentric series spread over a long time clarifies the effects of different therapeutic strategies and their combination in the management of DLGG