IceFire : videojuego online para Xbox 360

El proyecto consiste en la realización de un juego online para la consola de Microsoft Xbox 360 titulado IceFire. El videojuego pertenece al género de los MOBA y permitirá a los usuarios jugar de forma offline en el modo práctica pero tambien en un modo online donde crear o unirse a salas de juego donde empezar partidas en las que podrán elegir entre dos personajes distintos con sus habilidades propias y enfrentarse con su rival.El projecte consisteix en la realització d' un joc online per la consola de Microsoft Xbox 360 titulat IceFire. El videojoc pertany al génere dels MOBA i permetrà als usuaris jugar de forma offline al mode de práctica pero també en un mode online crear o afegir-se a salas de joc per començar partides on podran seleccionar entre dos personatges diferents amb les seves habilitats pròpies i enfrontar-se amb el seu rival.This project involves the creation of an online game for Microsoft's console Xbox 360 called IceFire. This videogame is a MOBA. Users are allowed to play offline in the training mode or they can use the online mode where they are able to create or to join a game room and to start a match with options to choose between two different characters with their typical skills and to play against other players

Intrinsic hardness of constitutive phases in WC–Co composites:Nanoindentation testing, statistical analysis, WC crystal orientation effectsand flow stress for the constrained metallic binder

The intrinsic hardness of the constitutive phases in WC–Co composites is investigated by combining experimental and statistical analysis nanoindentation techniques. It is done on the basis of considering the cemented carbide material as effectively heterogeneous at the microstructure scale, i.e. consisting of three phases defined by either different chemical nature (carbides and binder) or distinct carbide crystal orientation (i.e. with surface normal perpendicular to either basal or prismatic planes). As main outcome, experimentally measured and statistically significant intrinsic hardness values for the defined phases (WC and constrained metallic binder) are analyzed and determined. Besides the evidence of crystal anisotropy for the WC phase, they permit to identify and account the expected strengthening of the plastic-constrained metallic binder, a critical input parameter for hardness and toughness modelling as well as for microstructural design optimization of ceramic composites reinforced by ductile metallic ligamentsPeer ReviewedPostprint (author's final draft

Intrinsic hardness of constitutive phases in WC-Co composites: Nanoindentation testing, statistical analysis, WC crystal orientation effects and flow stress for the constrained metallic binder

The intrinsic hardness of the constitutive phases in WC-Co composites is investigated by combining experimental and statistical analysis nanoindentation techniques. It is done on the basis of considering the cemented carbide material as effectively heterogeneous at the microstructure scale, i.e. consisting of three phases defined by either different chemical nature (carbides and binder) or distinct carbide crystal orientation (i.e. with surface normal perpendicular to either basal or prismatic planes). As main outcome, experimentally measured and statistically significant intrinsic hardness values for the defined phases (WC and constrained metallic binder) are analyzed and determined. Besides the evidence of crystal anisotropy for the WC phase, they permit to identify and account the expected strengthening of the plastic-constrained metallic binder, a critical input parameter for hardness and toughness modelling as well as for microstructural design optimization of ceramic composites reinforced by ductile metallic ligaments. (C) 2015 Elsevier Ltd. All rights reserved.Postprint (published version

FiftyApp - El diari electrònic del Fifty-Fifty©

Aquest projecte està emmarcat en el context d'un programa real en l'àmbit de la salut i el benestar, anomenat Fifty-Fifty©, que fomenta la salut cardiovascular en adults i neix de la iniciativa de la Fundació SHE, promoguda pel Dr. Valentí Fuster, amb la finalitat de millorar la salut de manera integral en persones adultes mitjançant la modificació dels seus hàbits de salut, ajudant-les a corregir aquest hàbits i a auto-controlar els principals factors de risc de malaltia cardiovascular: alimentació no saludable, sobrepès/obesitat, sedentarisme, tabaquisme i tensió arterial elevada. Els participants d'aquest programa han de portar un control diari dels seus hàbits de salut, i la forma que tenen de fer-ho és enregistrant les mesures amb una llibreta de paper. La finalitat del Treball és desenvolupar una aplicació per a dispositius mòbils que substitueixi aquest enregistrament en paper per un sistema informatitzat més òptim i àgil. FiftyApp és l'aplicació pensada i dissenyada especialment per ajudar als participants d'aquest programa de salut. Permet portar un control acurat dels 5 factors de risc de malaltia cardiovascular i observar el progrés relatiu al factor objectiu del participant en qualsevol d'aquests factors: alimentació saludable, reducció del sobrepès, activitat física, cessament del tabaquisme i control de tensió arterial.This project is defined within the context of a real program in the field of health and well-being called Fifty-Fifty©. Participants in this program must keep a daily control of their health habits, and they do it by writing the measures and records with a paper notebook. The purpose of this work is to develop an application for mobile devices that replaces this writing on paper for an optimal and agile computerised system. FiftyApp is the application thought and designed especially to help participants in this health program. It allows to carry out an accurate control of the 5 risk factors for cardiovascular disease and observe the progress relative to the participant's target factor in any of these factors: healthy eating, reduction of overweight, physical activity, cessation of smoking and arterial blood pressure control.Este proyecto está enmarcado en el contexto de un programa real en el ámbito de la salud y el bienestar, denominado Fifty-Fifty©, que fomenta la salud cardiovascular en adultos y nace de la iniciativa de la Fundación SHE, promovida por el Dr. Valentí Carpintero, con el fin de mejorar la salud de manera integral persones adultas mediante la modificación de sus hábitos de salud, ayudándolas a corregir este hábitos y a auto-controlar los principales factores de riesgo de enfermedad cardiovascular: alimentación no saludable, sobrepeso/obesidad, sedentarismo, tabaquismo y tensión arterial elevada. Los participantes de este programa tienen que traer un control diario de sus hábitos de salud, y la forma que tienen de hacerlo es grabando las medidas con una libreta de papel. La finalidad del Trabajo es desarrollar una aplicación para dispositivos móviles que sustituya esta grabación en papel por un sistema informatizado más óptimo y ágil. FiftyApp es la aplicación pensada y diseñada especialmente para ayudar a los participantes de este programa de salud. Permite traer un control esmerado de los 5 factores de riesgo de enfermedad cardiovascular y observar el progreso relativo al factor objetivo del participante en cualquier de estos factores: alimentación saludable, reducción del sobrepeso, actividad física, cese del tabaquismo y control de tensión arterial

IceFire : videojuego online para Xbox 360

El proyecto consiste en la realización de un juego online para la consola de Microsoft Xbox 360 titulado IceFire. El videojuego pertenece al género de los MOBA y permitirá a los usuarios jugar de forma offline en el modo práctica pero tambien en un modo online donde crear o unirse a salas de juego donde empezar partidas en las que podrán elegir entre dos personajes distintos con sus habilidades propias y enfrentarse con su rival.El projecte consisteix en la realització d' un joc online per la consola de Microsoft Xbox 360 titulat IceFire. El videojoc pertany al génere dels MOBA i permetrà als usuaris jugar de forma offline al mode de práctica pero també en un mode online crear o afegir-se a salas de joc per començar partides on podran seleccionar entre dos personatges diferents amb les seves habilitats pròpies i enfrontar-se amb el seu rival.This project involves the creation of an online game for Microsoft's console Xbox 360 called IceFire. This videogame is a MOBA. Users are allowed to play offline in the training mode or they can use the online mode where they are able to create or to join a game room and to start a match with options to choose between two different characters with their typical skills and to play against other players

Intrinsic hardness of constitutive phases in WC–Co composites:Nanoindentation testing, statistical analysis, WC crystal orientation effectsand flow stress for the constrained metallic binder

The intrinsic hardness of the constitutive phases in WC–Co composites is investigated by combining experimental and statistical analysis nanoindentation techniques. It is done on the basis of considering the cemented carbide material as effectively heterogeneous at the microstructure scale, i.e. consisting of three phases defined by either different chemical nature (carbides and binder) or distinct carbide crystal orientation (i.e. with surface normal perpendicular to either basal or prismatic planes). As main outcome, experimentally measured and statistically significant intrinsic hardness values for the defined phases (WC and constrained metallic binder) are analyzed and determined. Besides the evidence of crystal anisotropy for the WC phase, they permit to identify and account the expected strengthening of the plastic-constrained metallic binder, a critical input parameter for hardness and toughness modelling as well as for microstructural design optimization of ceramic composites reinforced by ductile metallic ligamentsPeer Reviewe

Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide

Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16INK4a expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16INK4a overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions. What's new? Human papillomavirus (HPV) is linked to anal cancer through high HPV DNA-detection rates. Here, in one of the largest international studies to date, HPV DNA was detected in more than 88% of anal cancers and more than 95% of anal intraepithelial neoplasias grades 2/3. HPV16 was the most frequently detected virus type, followed by HPV18. Overexpression of p16INK4a, a surrogate marker for HPV-associated transformation, was found in 95% of HPV-positive anal cancers. The data implicate HPV as a causative factor in anal cancer.publishersversionpublishe