Nivel de ansiedad post COVID-19 y la gravedad del COVID-19 en pacientes de la unidad de medicina familiar No.73 de saltillo coahuila

Background: Coronavirus disease 2019 (COVID-19) is variable and has a negative impact on people's mental health. The psychiatric consequences of the COVID-19 disease can be anxiety disorders that can be defined as an anticipatory response to future harm or misfortune accompanied by a feeling of unpleasant dysphoria. Objective: To analyze the relationship between the level of post-COVID-19 anxiety and its severity in patients of the Family Medicine Unit No. 73 of Saltillo Coahuila. Methods: An analytical, observational, and longitudinal study was conducted in 314 patients who tested positive for COVID-19, selected by random probabilistic sampling. Zung's anxiety questionnaire was applied by means of two telephone calls, one at 3 months and another at 6 months. The data was captured and processed with the statistical program SPSS Statics 22. Results: The sample had an average age of 38.38 years, 56.4% were women. 95% of people diagnosed with COVID-19 had mild severity and the remaining 5% moderate. The level of anxiety, education, marital status and occupation were statistically significant (p<0.05) with respect to the severity of COVID-19. Conclusions: The level of anxiety post COVID-19 and its severity showed a significant difference (p = 0.000), with these results it can be deduced that the level of anxiety increases in relation to the severity of the disease.Introducción: La enfermedad por coronavirus 2019 (COVID-19), es variable y repercute negativamente sobre la salud mental de las personas. Las consecuencias psiquiátricas de la enfermedad COVID-19 pueden ser trastornos de ansiedad que puede definirse como una respuesta anticipatoria de un daño o desgracia futura acompañada de un sentimiento de disforia desagradable. Objetivo: Analizar la relación entre el nivel de ansiedad post COVID-19 y su gravedad en pacientes de la Unidad de Medicina Familiar No. 73. de Saltillo Coahuila. Métodos: Se realizó un estudio analítico, observacional, y longitudinal en 314 pacientes que resultaron positivo a COVID-19, seleccionados por muestreo probabilístico aleatorio. Por medio de dos llamadas telefónicas una a los 3 meses y otra a los 6 meses se aplicó el cuestionario de ansiedad de Zung. Los datos fueron capturados y procesados con el programa estadístico SPSS Statics 22. Resultados: La muestra tuvo una edad promedio de 38.38 años, el 56.4% fueron mujeres. El 95 % de las personas diagnosticadas con COVID-19 presentó una gravedad leve y el 5 % restante moderado. El nivel de ansiedad, escolaridad, estado civil y ocupación fueron estadísticamente significativos  (p<0.05) con respecto a la gravedad de COVID-19. Conclusiones: El nivel de ansiedad post COVID-19 y su gravedad mostró una diferencia significativa (p = 0.000), con dichos resultados se deduce que el nivel de ansiedad incrementa en relación a la gravedad de la enfermedad

CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients

Abstract. Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high-throughput RNA sequencing in a broader set of patients. For microarrays, mRNA was taken from 20 skin biopsies of 10 patients with VV (pigmented and depigmented skin biopsy of each), and 5 biopsies of healthy subjects matched for age and sex were used as a control. A signature was identified that contains the expression pattern of 722 genes between depigmented vitiligo skin vs. healthy control, 1,108 between the pigmented skin of vitiligo vs. healthy controls and 1,927 between pigmented skin, depigmented vitiligo and healthy controls (P<0.05; false discovery rate, <0.1). When comparing the pigmented and depigmented skin of patients with vitiligo, which reflects the real difference between both skin types, 5 differentially expressed genes were identified and further validated in 45 additional VV patients by RNA sequencing. This analysis showed significantly higher RNA levels of calpain-3, dopachrome tautomerase, melan-A and tyrosinase-related protein-1 genes. The data revealed that the pigmented skin of vitiligo is already affected at the level of gene expression and that the main differences between pigmented and non-pigmented skin are explained by the expression of genes associated with pigment metabolism

Casos de estudio en México y Latinoamérica

Ante la presencia de conflictos sociales y territoriales, las comunidades organizadas buscan estrategias de solución y confrontación. Es el estudio de dichos movimientos, lo que motiva a la publicación de éste libro: Respuestas comunitarias ante conflictos ambientales. Casos de estudio en México y Latinoamérica, reúne catorce textos que analizan las respuestas sociales y documentan la acción colectiva de comunidades que se han organizado para autogestionar soluciones ante conflictos territoriales, económicos y ambientales, en su propio entorno. Las aportaciones de investigadores y activistas, desde enfoques teóricos y metodológicos particulares, exponen casos de estudio sobre organizaciones formales e informales que se han conformado para afrontar los retos que representan proyectos productivos como fábricas cementeras, mineras, puertos, productores de energía, entre otros. Los enfoques analíticos tocan también temas nodales en el estudio de la acción colectiva como la ética, el despojo, los derechos humanos y las estrategias de comunicación y visibilización. Este material, que reúne estudios hechos en distintos lugares de México y Latinoamérica, es un compendio de métodos de investigación y un acercamiento al estudio de los movimientos sociales.UAEMEX, CONACyT, SE

Classifying the evolutionary and ecological features of neoplasms

The consensus conference was supported by Wellcome Genome Campus Advanced Courses and Scientific Conferences. C.C.M. is supported in part by US NIH grants P01 CA91955, R01 CA149566, R01 CA170595, R01 CA185138 and R01 CA140657 as well as CDMRP Breast Cancer Research Program Award BC132057. M.J. is supported by NIH grant K99CA201606. K.S.A. is supported by NCI 5R21 CA196460. K. Polyak is supported by R35 CA197623, U01 CA195469, U54 CA193461, and the Breast Cancer Research Foundation. K.J.P. is supported by NIH grants CA143803, CA163124, CA093900 and CA143055. D.P. is supported by the European Research Council (ERC-617457- PHYLOCANCER), the Spanish Ministry of Economy and Competitiveness (BFU2015-63774-P) and the Education, Culture and University Development Department of the Galician Government. K.S.A. is supported in part by the Breast Cancer Research Foundation and NCI R21CA196460. C.S. is supported by the Royal Society, Cancer Research UK (FC001169), the UK Medical Research Council (FC001169), and the Wellcome Trust (FC001169), NovoNordisk Foundation (ID 16584), the Breast Cancer Research Foundation (BCRF), the European Research Council (THESEUS) and Marie Curie Network PloidyNet. T.A.G. is a Cancer Research UK fellow and a Wellcome Trust funded Investigator. E.S.H. is supported by R01 CA185138-01 and W81XWH-14-1-0473. M.Gerlinger is supported by Cancer Research UK and The Royal Marsden/ICR National Institute of Health Research Biomedical Research Centre. M.Ge., M.Gr., Y.Y., and A.So. were also supported in part by the Wellcome Trust [105104/Z/14/Z]. J.D.S. holds the Edward B. Clark, MD Chair in Pediatric Research, and is supported by the Primary Children's Hospital (PCH) Pediatric Cancer Research Program, funded by the Intermountain Healthcare Foundation and the PCH Foundation. A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer. Y.Y. is a Cancer Research UK fellow and supported by The Royal Marsden/ICR National Institute of Health Research Biomedical Research Centre. E.S.H. was supported in part by PCORI grants 1505–30497 and 1503–29572, NIH grants R01 CA185138, T32 CA093245, and U10 CA180857, CDMRP Breast Cancer Research Program Award BC132057, a CRUK Grand Challenge grant, and the Breast Cancer Research Foundation. A.R.A.A. was funded in part by NIH grant U01CA151924. A.R.A.A., R.G. and J.S.B. were funded in part by NIH grant U54CA193489

25th Annual Computational Neuroscience Meeting: CNS-2016

Abstracts of the 25th Annual Computational Neuroscience Meeting: CNS-2016 Seogwipo City, Jeju-do, South Korea. 2–7 July 201