Common motifs in scientific workflows: An empirical analysis

While workflow technology has gained momentum in the last decade as a means for specifying and enacting computational experiments in modern science, reusing and repurposing existing workflows to build new scientific experiments is still a daunting task. This is partly due to the difficulty that scientists experience when attempting to understand existing workflows, which contain several data preparation and adaptation steps in addition to the scientifically significant analysis steps. One way to tackle the understandability problem is through providing abstractions that give a high-level view of activities undertaken within workflows. As a first step towards abstractions, we report in this paper on the results of a manual analysis performed over a set of real-world scientific workflows from Taverna and Wings systems. Our analysis has resulted in a set of scientific workflow motifs that outline i) the kinds of data intensive activities that are observed in workflows (data oriented motifs), and ii) the different manners in which activities are implemented within workflows (workflow oriented motifs). These motifs can be useful to inform workflow designers on the good and bad practices for workflow development, to inform the design of automated tools for the generation of workflow abstractions, etc

Hydrogen-ion driven molecular motions in Cu2+-complexes of a ditopic phenanthrolinophane ligand

One of the first kinetic evaluations of a metal ion interchange between the two coordination sites of a ditopic macrocycle is presented.Garcia-España Monsonis, Enrique, [email protected] ; Soriano Soto, Concepción, [email protected] ; Verdejo Viu, Begoña, [email protected]

Risk of malignancy in resected pancreatic mucinous cystic neoplasms

BACKGROUND: Pancreatic mucinous cystic neoplasms (MCNs) are rare mucin-producing cystic tumours defined by the presence of ovarian-type stroma. MCNs have a malignant potential and thus surgery is frequently performed. The aim of this cohort study was to define better the criteria for surgical resection in patients with MCN. METHODS: This multicentre retrospective study included all resected MCNs between 2003 and 2015 in participating centres. Lesions without ovarian-type stroma were excluded. Patient characteristics, preoperative findings, histopathology findings and follow-up data were recorded. RESULTS: The study included 211 patients; their median age was 53 (range 18-82) years, and 202 (95·7 per cent) were women. Median preoperative tumour size was 55 (range 12-230) mm. Thirty-four of the 211 (16·1 per cent) were malignant, and high-grade dysplasia (HGD) was found in a further 13 (6·2 per cent). One-third of MCNs in men were associated with invasive cancer, compared with 15·3 per cent in women. Five cases of malignant transformation occurred in MCNs smaller than 4 cm. All cases of malignancy or HGD were associated with symptoms or features of concern on preoperative cross-sectional imaging. In multivariable analysis, raised carbohydrate antigen 19-9 (odds ratio (OR) 10·54, 95 per cent c.i. 2·85 to 218·23; P < 0·001), tumour size (OR 4·23, 3·02 to 11·03; P = 0·001), mural nodules (OR 3·55, 1·31 to 20·55; P = 0·002) and weight loss (OR 3·40, 2·34 to 12·34; P = 0·034) were independent factors predictive of malignant transformation. CONCLUSIONS: Small indeterminate MCNs with no symptoms or features of concern may safely be observed as they have a low risk of malignant transformation

La esofagitis eosinofílica como causa de impactación por cuerpo extraño: análisis de nuestra experiencia

Introduction: food bolus impaction in the esophagus, is a frequent symptom debut in patients with eosinophilic esophagitis (EEO). This may mean a change in the epidemiology and clinical management of this emergency endoscopy. Methods: Retrospective analysis of 131 emergency endoscopic foreign body impaction (FB). We studied the epidemiological characteristics, endoscopic findings, type of FB, the rate of impaction and history of the 3 years preceding the survey. Statistical analysis was performed using t-student and tests ×2. Results: 131 patients, 65% male, mean age 56 years. Endoscopic findings: normal esophagus 34.4% (45/131) and 20% endoscopic findings of EEO (26/131). Meat bolus was the most common FB (60.3%, 79/131). Patients hit by suspected food EEO was the most frequent endoscopic finding. The subgroup of patients with impacted food bolus with a final diagnosis of EEO presented a lower mean age than those with causes of impaction (36.47 vs. 64.45, P = 0.00) and a higher percentage of background previous impaction (38% vs. 6%, RR = 15.70 95% (from 3.60 to 62.50), p = 0.00). Conclusion: Emergency FB impaction is a common event in our clinical practice. EEO is a case to be considered in such patients, so we suspected in patients impacted food bolus, young and with a history of previous impaction.Introduccion: La impactacion del bolo alimentario en el esofago, supone un sintoma de debut frecuente en los pacientes con esofagitis eosinofilica (EEo). Este hecho, puede suponer un cambio en la epidemiologia y en el manejo clinico de esta urgencia endoscopica. Material y metodos: Analisis retrospectivo sobre 131 urgencias endoscopicas por impactacion de cuerpo extrano (CE). Se estudiaron las caracteristicas epidemiologicas, hallazgos endoscopicos, el tipo de CE, la tasa de desimpactacion y antecedentes de impactacion los 3 anos previos al 2 estudio. El analisis estadistico se realizo mediante los test de �Ô y t-student. Resultados: 131 pacientes, 65% varones; edad media 56 anos. Hallazgos endoscopicos: 34,4% esofago normal (45/131) y el 20% esofago de caracteristicas endocopicas de EEo (26/131). El bolo de carne fue el CE mas frecuente (60,3%; 79/131). En los pacientes impactados por alimento la sospecha de EEo fue el hallazgo endoscopico mas frecuente. El subgrupo de pacientes impactados con bolo alimentario y con diagnostico final de EEo presento una edad media menor, que aquellos con otras causas de impactacion (36,47 vs. 64,45; p=0,00), asi como un mayor porcentaje de antecedentes de impactacion previos (38% vs. 6%; RR= 15,70 IC95%(3,60- 62,50; p=0,00). Conclusion: La urgencia por impactacion de CE es un hecho frecuente en nuestra practica clinica. La EEo es una causa a tener en cuenta en este tipo de pacientes, por lo que debemos sospecharla ante enfermos impactados por bolos alimentarios, jovenes y con antecedentes de impactacion previa

Hydrogen-ion driven molecular motions in Cu2+-complexes of a ditopic phenanthrolinophane ligand

One of the first kinetic evaluations of a metal ion interchange between the two coordination sites of a ditopic macrocycle is presented

Factores predictores de esofagitis eosinofílica en impactación esofágica por bolo alimenticio

Antecedentes: La impactación esofágica por bolo alimenticio es un síntoma de debut en pacientes diagnosticados de esofagitis eosinofílica, lo cual supone un cambio en la epidemiología y el manejo de esta urgencia. Objetivo: Detectar factores predictores de esofagitis eosinofílica en pacientes con impactación esofágica por bolo alimenticio. Métodos: Se analizaron de forma retrospectiva pacientes atendidos por impactación por cuerpo extraño. Se estudiaron las características epidemiológicas, los hallazgos endoscópicos y los antecedentes de impactación. El análisis estadístico se realizó mediante los test de la t de Student y de la χ2. Se elaboró un modelo de regresión logística. Resultados: Ciento treinta y un pacientes, 65% varones, con una edad media de 56 años. En los pacientes con impactación por bolo alimenticio (n = 89), la sospecha endoscópica de esofagitis eosinofílica fue el hallazgo más frecuente. De estos, aquellos sin confirmación histológica fueron excluidos (n = 7); el resto de los pacientes (n = 82) se dividió en 2 grupos: esofagitis eosinofílica confirmada (grupo A) (n = 18) y otros hallazgos endoscópicos (grupo B) (n = 64). El grupo A presentaba una menor edad media (36.47 vs. 64.45; p = 0.001) e historia de impactación previa más frecuente que el grupo B (38 vs. 6%; OR = 15.70; IC del 95%, 3.60-62.50; p = 0.001). Edad e historia de impactación se comportaron como predictores de esofagitis eosinofílica con una sensibilidad del 82%, una especificidad del 80% y un rendimiento del 84% (p < 0.001). Conclusión: Edad y antecedentes de impactación predicen la presencia de esofagitis eosinofílica en pacientes con impactación por bolo alimenticio