276 research outputs found

    PSS42 INTERVENTIONAL PROCEDURES IN GLAUCOMA: RESOURCES AND COSTS IN FIVE EUROPEAN COUNTRIES

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    Damage detections in nonlinear vibrating thermally loaded plates

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    In this work, geometrically nonlinear vibrations of fully clamped rectangular plates subjected to thermal changesare used to study the sensitivity of some vibration response parameters to the presence of damage and elevated temperature. The geometrically nonlinear version of the Mindlin plate theory is used to model the plate behaviour.Damage is represented as a stiffness reduction in a small area of the plate. The plates are subjected to harmonicloading leading to large amplitude vibrations and temperature changes. The plate vibration response is obtained by a pseudo-load mode superposition method. The main results are focussed on establishing the influence of damage on the vibration response of the heated and the unheated plates and the change in the time-history diagrams and the Poincaré maps caused by damage and elevated temperature. The damage criterion formulated earlier for nonheated plates, based on analyzing the points in the Poincaré sections of the damaged and healthy plate, is modified and tested for the case of plates additionally subjected to elevated temperatures. The importance of taking into account the actual temperature in the process of damage detection is shown

    A Continuum Model for Metabolic Gas Exchange in Pear Fruit

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    Exchange of O2 and CO2 of plants with their environment is essential for metabolic processes such as photosynthesis and respiration. In some fruits such as pears, which are typically stored under a controlled atmosphere with reduced O2 and increased CO2 levels to extend their commercial storage life, anoxia may occur, eventually leading to physiological disorders. In this manuscript we have developed a mathematical model to predict the internal gas concentrations, including permeation, diffusion, and respiration and fermentation kinetics. Pear fruit has been selected as a case study. The model has been used to perform in silico experiments to evaluate the effect of, for example, fruit size or ambient gas concentration on internal O2 and CO2 levels. The model incorporates the actual shape of the fruit and was solved using fluid dynamics software. Environmental conditions such as temperature and gas composition have a large effect on the internal distribution of oxygen and carbon dioxide in fruit. Also, the fruit size has a considerable effect on local metabolic gas concentrations; hence, depending on the size, local anaerobic conditions may result, which eventually may lead to physiological disorders. The model developed in this manuscript is to our knowledge the most comprehensive model to date to simulate gas exchange in plant tissue. It can be used to evaluate the effect of environmental stresses on fruit via in silico experiments and may lead to commercial applications involving long-term storage of fruit under controlled atmospheres

    The renewable energy and energy efficiency potential of Waitakere City : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Technology in Energy Management at Massey University

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    Electricity restrictions and blackouts have occurred in Waitakere City in the past and are likely to occur again in the future unless the city can become more self reliant by meeting, at least in part, the increasing energy requirements for what is one of the fastest growing cities in New Zealand. In this study the potentials for energy conservation, energy efficiency and renewable energy resources have been broadly quantified and assessed using desktop analysis of publicly available data for stationary final use energy systems (i.e. excluding transportation) within the geographical area of Waitakere City and adjoining waters. It was found that energy efficiency and energy conservation measures can consistently and predictably achieve overall energy savings and reduce daily and seasonal peak demand. The best renewable energy resource potential exists with solar and geothermal for heating applications and wave, offshore and inshore wind and tidal currents for electricity generation. There is very limited potential for hydro and bioenergy systems beyond what already exists. PV solar and land based wind power generation are currently only feasible for limited off-grid applications. This scoping study confirms the achievability of the vision expressed in Waitakere City Council's "Long Term Council Community Plan" (LTCCP) that by 2020 " Waitakere City will be an energy cell, not an energy sink. Air quality supports good health". A range of flagship projects have been identified to progress the achievement of this vision. Waitakere City Council can use this report as part of the development of a comprehensive energy management plan

    Characterizing the tissue of apple air-dried and osmo-air-dried rings by X-CT and OCT and relationship with ring crispness and fruit maturity at harvest measured by TRS

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    Air-dried apple rings were prepared from ‘Golden Delicious’ apples selected at harvest as less mature and more mature according to the absorption coefficient measured at 670 nm by time-resolved reflectance spectroscopy (TRS), stored in air for 5 months, and subjected to air-drying with (OSMO) and without (noOSMO) osmodehydration pre-treatment (60% sucrose syrup). Selected rings were submitted to microstructural analysis by X-ray computed tomography (X-CT), to subsurface structure analysis by optical coherence tomography (OCT) and to texture and sound emission analysis by bending–snapping test. Higher crispness index, higher number of sound events and higher average sound pressure level (SPL) characterized the OSMO rings. Total porosity was related to SPLav 60, pore fragmentation index to fracturability and specific surface area to the work required to snap the ring. A differentiation of the drying treatments, as well as of the products according to the TRS maturity class at harvest was obtained analyzing by principal component analysis (PCA) microstructure parameters and texture and acoustic parameters. The differences in mechanical and acoustic characteristics between OSMO and noOSMO rings were due to the different subsurface structure as found with OCT analysis

    Cutting Edge Technologies in Postharvest Research: Journey to the Centre of the Fruit

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    Food microstructure is at the base of many food quality roperties. The EU project InsideFood focuses on the pplication of high technological techniques to inspect internal quality of fruit. Tomographic techniques such as magnetic resonance imaging, X-ray computed tomography, optical coherence tomography and confocal microscopy can be used to obtain information about the 3-D microstructure of the fruit which is believed to affect quality attributes such as texture. Optical techniques such as spatially or time resolved reflectance spectroscopy may also be used to obtain information about fruit microstructure. This microstructural information can be incorporated in multiscale simulation models to predict the cellular gas concentrations in fruit. Such models aid towards a better understanding of, for instance, controlled atmosphere storage of apple and postharvest behaviour of fruits and vegetables in general

    A 3-D microscale model for Co2 GasTransport in tomato leaves during photosynthesis

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    Exchange of CO2 in tomato (Solanum lycopersicum L.) leaves was modelled using combined gas diffusion and photosynthesis kinetics in a real 3-D geometric representation of the cellular microstructure, obtained by synchrotron radiation X-ray microtomography. The microscale model for gas exchange accounted for diffusive mass transport of CO2 in the intercellular space (pores), the cell wall network and the intracellular liquid of cells. The photosynthesis kinetics described by the extended Farquhar, von Caemmerer & Berry model were coupled to the gas exchange inside the mesophyll cells. The coupled model was validated by means of gas exchange and chlorophyll fluorescence measurements. The model provides detailed insight into the mechanisms of gas exchange and insight into the effects of changes in ambient CO2 concentration or photon flux density on stomatal and mesophyll conductance. The resistance to diffusion of CO2 from the intercellular air spaces within the leaf through the mesophyll to the sites of carboxylation during photosynthesis depended on the 3-D microstructure of leaf tissue. The model represents an important step forward to study CO2 diffusion coupled to photosynthesis at the leaf tissue level, taking into account its actual 3-D microstructure

    A treatment recommender clinical decision support system for personalized medicine: method development and proof-of-concept for drug resistant tuberculosis

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    Background Personalized medicine tailors care based on the patient’s or pathogen’s genotypic and phenotypic characteristics. An automated Clinical Decision Support System (CDSS) could help translate the genotypic and phenotypic characteristics into optimal treatment and thus facilitate implementation of individualized treatment by less experienced physicians. Methods We developed a hybrid knowledge- and data-driven treatment recommender CDSS. Stakeholders and experts first define the knowledge base by identifying and quantifying drug and regimen features for the prototype model input. In an iterative manner, feedback from experts is harvested to generate model training datasets, machine learning methods are applied to identify complex relations and patterns in the data, and model performance is assessed by estimating the precision at one, mean reciprocal rank and mean average precision. Once the model performance no longer iteratively increases, a validation dataset is used to assess model overfitting. Results We applied the novel methodology to develop a treatment recommender CDSS for individualized treatment of drug resistant tuberculosis as a proof of concept. Using input from stakeholders and three rounds of expert feedback on a dataset of 355 patients with 129 unique drug resistance profiles, the model had a 95% precision at 1 indicating that the highest ranked treatment regimen was considered appropriate by the experts in 95% of cases. Use of a validation data set however suggested substantial model overfitting, with a reduction in precision at 1 to 78%. Conclusion Our novel and flexible hybrid knowledge- and data-driven treatment recommender CDSS is a first step towards the automation of individualized treatment for personalized medicine. Further research should assess its value in fields other than drug resistant tuberculosis, develop solid statistical approaches to assess model performance, and evaluate their accuracy in real-life clinical settings

    Leptin Affects Life History Decisions in a Passerine Bird: A Field Experiment

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    BACKGROUND: Organisms face trade-offs regarding their life-history strategies, such as decisions of single or multiple broods within a year. In passerines displaying facultative multiple breeding, the probability of laying a second clutch is influenced by several life-history factors. However, information about the mechanistic background of these trade-offs is largely lacking. Leptin is a protein hormone produced by white fat cells, and acts as a signal between peripheral energy depots and the central nervous system. In addition, leptin affects cells at all levels of the reproductive axis and plays a critical role in regulating the allocation of metabolic energy to reproduction. As such, it is possible that leptin levels influence the decision of whether or not to invest time and energy into a second clutch. Accordingly, we expect a treatment with exogenous leptin to result in an increased number of second broods. METHODOLOGY/PRINCIPAL FINDINGS: At a later stage during the first brood, female great tits were treated either with long-term leptin-filled cholesterol pellets (the experimental birds) or with pellets containing only cholesterol (the control birds). We found that leptin-treated females were significantly more likely to have a second brood and that the earlier females were more likely to lay a second clutch than the late females. CONCLUSIONS/SIGNIFICANCE: As both timing of first brood and treatment with leptin were important in the decision of having multiple broods, the trade-offs involved in the breeding strategy most likely depend on multiple factors. Presumably leptin has evolved as a signal of energy supply status to regulate the release of reproductive hormones so that reproduction is coordinated with periods of sufficient nutrients. This study investigated the role of leptin as a mediator between energy resources and reproductive output, providing a fundamentally new insight into how trade-offs work on a functional basis
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