Gastric and Enteric Metastization of Invasive Lobular Breast Carcinoma

O carcinoma lobular invasivo (CLI) representa 5-15% dos casos de cancro invasivo da mama, diferindo do carcinoma ductal invasivo(CDI), o tumor invasivo mais frequente da mama, quer na forma de apresentação clínica, quer nos aspectos imagiológicos e histológicos, assim como no padrão de metastização. O objectivo deste artigo passa pelo relato clínico de um padrão atípico de metastização de cancro da mama. Mulher de 80 anos, que apresentava queixas de dor abdominal, com 6 meses de evolução, de carácter generalizado, com maior intensidade nos quadrantes direitos, associada a episódios de sub-oclusão. O exame objectivo revelou volumosa hérnia incisional paramediana direita sem sinais de sofrimento e uma lesão ulcerada da mama esquerda nunca antes revelada pela doente. Realizou uma mamografia que mostrou uma lesão T4 e a biópsia da mesma revelou Carcinoma Ductal Invasivo. Por apresentar anemia microcítica hipocrómica de 7 g/dL realizou também uma Endoscopia Digestiva Alta que demonstrou uma úlcera da pequena curvatura gástrica cuja biópsia revelou um carcinoma difuso. Optou-se pela intervenção cirúrgica com ideação paliativa. Foi efectuada mastectomia simples esquerda e correcção de hérnia incisional com enterectomia segmentar. Os resultados histológicos das peças operatórias foram surpreendentes: Carcinoma lobular invasivo da mama e metástase do mesmo no segmento de intestino ressecado. Foram revistas as lâminas referentes à biópsia gástrica previamente realizada, tendo sido feito estudo imunohistoquímico que mostrou positividade para os receptores hormonais o que favorecia tratar-se de metástase de carcinoma lobular da mama no estômago. Como conclusão temos a referir que o CLI apresenta um padrão distinto de metastização em relação ao CDI, com diferentes órgãos-alvo, realçando o papel fundamental da suspeição clínica e de uma histologia exigente para o seu diagnóstico

Social Justice Driven STEM Learning (STEMJ): A Curricular Framework for Teaching STEM in a Social Justice Driven, Urban, College Access Program.

This article presents the curricular framework for a social justice driven STEM curriculum (i.e., STEMJ) within an out-of-school time program for Boston Public high school students (i.e., College Bound) at Boston College. Starting with a discussion of the authors’ ideological positionality within critical social justice discourses, the authors share how Bronfenbrenner’s (1994) General Ecological Model provides a conceptual framework for operationalizing social justice inquiry with and through STEM. Positioning this curriculum within the College Bound program’s overall design gives readers a sense of how the program’s College and Career, Identity and Society, and STEMJ curriculums work in tandem to support the programs desired outcomes of students’ increased critical consciousness and college matriculation. Lessons learned and future directions are also included in acknowledgement of the necessity of ongoing reflection and adaptation to fulfill the program’s ambitious goals

Rice Molecular Breeding Laboratories in the Genomics Era: Current Status and Future Considerations

Using DNA markers in plant breeding with marker-assisted selection (MAS) could greatly improve the precision and efficiency of selection, leading to the accelerated development of new crop varieties. The numerous examples of MAS in rice have prompted many breeding institutes to establish molecular breeding labs. The last decade has produced an enormous amount of genomics research in rice, including the identification of thousands of QTLs for agronomically important traits, the generation of large amounts of gene expression data, and cloning and characterization of new genes, including the detection of single nucleotide polymorphisms. The pinnacle of genomics research has been the completion and annotation of genome sequences for indica and japonica rice. This information—coupled with the development of new genotyping methodologies and platforms, and the development of bioinformatics databases and software tools—provides even more exciting opportunities for rice molecular breeding in the 21st century. However, the great challenge for molecular breeders is to apply genomics data in actual breeding programs. Here, we review the current status of MAS in rice, current genomics projects and promising new genotyping methodologies, and evaluate the probable impact of genomics research. We also identify critical research areas to “bridge the application gap” between QTL identification and applied breeding that need to be addressed to realize the full potential of MAS, and propose ideas and guidelines for establishing rice molecular breeding labs in the postgenome sequence era to integrate molecular breeding within the context of overall rice breeding and research programs

Water safety : water potability of hospital in Minas Gerais, Brazil.

A Portaria 2.914/11 do Minist?rio da Sa?de do Brasil disp?e dos procedimentos e par?metros de controle e vigil?ncia da qualidade de ?gua para consumo humano e potabilidade. Neste sentido, faz-se necess?rio o monitoramento da qualidade das ?guas de unidades de atendimento hospitalar, devido ?s caracter?sticas de fragilidade de seus usu?rios. O presente trabalho visou analisar a qualidade da ?gua de abastecimento de um hospital geral de porte m?dio da regi?o central do estado de Minas Gerais, Brasil. Para isso, foram realizadas campanhas de coleta entre os meses de setembro de 2014 e novembro de 2016, em pontos amostrais variados, conforme determina??o da vigil?ncia sanit?ria. Os par?metros analisados foram Cloreto, Cloro Residual, Condutividade, Dureza Total, Nitrog?nio de Nitrito e de Nitrato, pH, Turbidez, Coliformes Totais, Coliformes Termotolerantes, Escherichia coli e contagem de Bact?rias Heterotr?ficas. Os resultados das amostras analisadas mostraram-se dentro dos limites estabelecidos pela portaria em rela??o aos par?metros f?sico- qu?micos, com exce??o de cloro residual e condutividade, que apresentaram respectivamente 32,5% e 10,1% das amostras fora dos padr?es. Observou-se a ocorr?ncia de Coliformes Termotolerantes em novembro de 2015, o qual foi rapidamente contornado pela adi??o de cloro nos reservat?rios. Percebe-se, desta forma, a import?ncia e pertin?ncia da continuidade do programa de monitoramento da ?gua de abastecimento do referido hospital.The Decree 2,914/11 of the Ministry of Health of Brazil has the procedures and parameters of control and surveillance of water quality for human consumption and potability. In this Ordinance all the procedures and parameters of control and monitoring of drinking water are described. In this sense, it is necessary to monitor the quality of the water in hospital care units, due to the fragility characteristics of its users. The present study aimed to analyse the quality of the water supply of a medium-sized general hospital in the central region of the state of Minas Gerais, Brazil. In order to do that, collection campaigns were carried out between September 2014 and November 2016, at various sampling points, as determined by the sanitary surveillance. The analyzed parameters were Chloride, Residual Chlorine, Conductivity, Total Hardness, Nitrogen of Nitrite and Nitrate, pH, Turbidity, Total Coliforms, Thermotolerant Coliforms, Escherichia coli and Heterotrophic Bacterial count. The results of the analyzed samples were within the parameters established by the ordinance regarding to the physical-chemical parameters, except for residual chlorine and conductivity, which presented 32.5% and 10.1% respectively, of samples out of the established. It was observed the occurrence of thermotolerant coliforms in November 2015, which was quickly overcome by the addition of chlorine in the reservoirs. According to the results was noticed the importance of the continuity of the water supply monitoring program of the cited hospital