Uma via sobre o mar: práticas italianas experienciadas nas aulas de teatro no ensino médio do CEFET de Florianópolis

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Programa de Pós-Graduação em EducaçãoA presente dissertação é o resultado da análise de aulas de teatro realizadas de forma curricular com adolescentes do Ensino Médio e observa como exercícios propostos para aulas do mesmo tipo na Itália foram recebidas por alunos de uma escola de Florianópolis. Os objetivos desta pesquisa são: verificar como as aulas curriculares de teatro têm sido realizadas em uma escola de Ensino Médio de Florianópolis e nas séries equivalentes na região da Lombradia, na Itália, registrar a reação dos alunos da escola do Brasil aos exercícios propostos para o ensino da matéria na Itália; observar se as técnicas utilizadas nas aulas de teatro do Ensino Médio interferem no dia-a-dia de seus praticantes adolescentes e de que forma se dá essa interferência. Como metodologia foi realizada uma pesquisa bibliográfica, complementada com observação passiva de aulas de teatro; um período de assistência a um curso de formação de professores na Itália; e a implantação de algumas das técnicas desenvolvidas nas aulas da Itália, para os alunos do Brasil. No final do processo foi realizada uma entrevista com os estudantes. Como referencial teórico utilizo principalmente Augusto Boal, Flavio Desgranges e Claudio Bernardi. No resultado foi possível verificar que, embora as aulas de teatro tenham uma boa recepção pelos alunos, que a consideram muito importante para trabalhar os próprios limites, desenvolver a confiança, a autonomia e o espírito de grupo, ainda existem muitas dificuldades a ser superadas para que seja realizado um trabalho realmente satisfatório. As principais barreiras a serem transpostas estão relacionadas com a carga horária que geralmente é insuficiente, com a falta de recursos dispensados para a boa realização das atividades e com o descaso dos demais membros da escola e também dos pais dos alunos. O período de estudos realizados não foi longo o suficiente para poder observar a influência das aulas na vida dos alunos envolvidos na pesquisa. The present study is the result of the theater classes analysis performed in a curricular way with adolescents of the High School and observes how proposed exercices for classes of the same kind in Italy were received by students of a school in Florianópolis. The aims of this research are: To verify how the curricular theater classes have been performed in a school of the High School in Florianópolis and in the equivalent grades in the region of Lombardia, in Italy; to record the students reaction of the Brazilian school to the proposed exercices to the teaching of the subject in Italy; to observe if the techniques used in theater classes of the High School interfere in the day-to-day of the adolescents trainees and in which way occurs this interference. As a method one research in bibliography was performed, completed with passive observation in theater classes; a period attending to a teachers formation course in Italy; and the implementation of some of the techniques developed in the classes in Italy, to the students in Brazil. At the end of the process an interview with the students was made. As theory references it is employed mainly Augusto Boal, Flavio Desgranges and Claudio Bernardi. As results it is possible to verify that although the theater classes have had a good acceptance from the students, who found it very important to work out their own limitations, to develop self-confidence, autonomy and the group spirit, there are still many difficulties to surmount in order to realize a really satisfactory work. The main obstacles to be transposed are related to the amount of hours which generally is insufficient, to the lack of resources spended in the good achievement of the activities and to the disregard of others members of the school as well as of the students fathers. The performed period of studies was not long enough in order to observe the influence of the classes in the life of the students involved in the research

The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report

BACKGROUND: The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is particularly challenging since first and second-generation Tyrosine Kinase Inhibitors (TKIs) are ineffective. Ponatinib, blinatumomab, chemotherapy and transplant are the currently available options in these cases. CASE PRESENTATION: We here report the case of a young Ph+ ALL patient who relapsed on front-line dasatinib therapy because of two independent T315I-positive subclones, resulting from different nucleotide substitutions -one of whom never reported previously- and where additional mutant clones outgrew and persisted despite ponatinib, transplant, blinatumomab and conventional chemotherapy. Deep Sequencing (DS) was used to dissect the complexity of BCR-ABL1 kinase domain (KD) mutation status and follow the kinetics of different mutant clones across the sequential therapeutic approaches. CONCLUSIONS: This case presents several peculiar and remarkable aspects: i) distinct clones may acquire the same amino acid substitution via different nucleotide changes; ii) the T315I mutation may arise also from an 'act' to 'atc' codon change; iii) the strategy of temporarily replacing TKI therapy with chemo or immunotherapy, in order to remove the selective pressure and deselect aggressive mutant clones, cannot always be expected to be effective; iv) BCR-ABL1-mutated sub-clones may persist at very low levels (undetectable even by Deep Sequencing) for long time and then outcompete BCR-ABL1-unmutated ones becoming dominant even in the absence of any TKI selective pressure

Prevalence of intestinal parasitosis in patients afferent to the Hospital of Desio (Monza e Brianza), Italy

From may 2008 to June 2010 we have analyzed faecal samples of 2306 subjects: in the subjects was performed the coproparassitological standard examination and in 523 of them was performed scotch test. Of the 2306 subjects examined, 101 resulted positive, 59 to the coproparasitological exam, 43 to scotch test, and 1 to both of them (Taenia spp.). In three cases we have found positivity for two different parassitological species. Pathogenic parasites were found in 77 cases, 61 autoctones and 16 immigrates. The helminths found were Enterobius vermicularis, the prevalent, and Taenia spp., Ascaris lumbricoides, Diphillobothrium latum, Trichuris Trichiura, while the Protozoa were Giardia duodenalis and Entamoeba histolytica/dispar. Non pathogenic species were found in 27 cases, 15 among autoctones and 12 among immigrates: in detail Entamoeba coli, Endolimax nana, Blastocystis hominis. The total prevalence of parassitosis is low (4,2%), 20,0% in immigrate subjects and 3,4% in native subjects. Our results show that the 0-10 age group have an higher prevalence for Enterobius vermicularis. Some considerations are related for improving the complete or more exhaustive diagnosis concerning the intestinal parasitosis

Lack of evidence of Chikungunya virus infection among blood donors during the Chikungunya outbreak in Lazio Region, Italy, 2017

Background: The latest European Chikungunya virus (CHIKV) outbreak occurred in Italy in 2017, in the municipalities of Anzio and Rome (Lazio Region), with a secondary outbreak in the Calabrian Region. Most CHIKV infections are symptomatic but about 15% of people who acquire the infection may be asymptomatic. A retrospective study was conducted with the aim of assessing the prevalence of recent/ongoing CHIKV infections on the blood donor population in the Lazio Region, during the 2017 outbreak (including in the period before it was detected). Methods: The study was conducted on 4595 plasma samples from donors who donated in 14 different Blood Establishments in the Lazio Region, in the period June-November 2017. A total of 389 of these samples were collected in provinces not affected by the outbreak and were used as negative controls. All samples were tested for IgM detection by the use of an ELISA test, and positive samples were tested for confirmation through the use of a PRNT. Molecular tests were performed on sera that were found to be IgM-positive or borderline. Results: A total of 41 (0.89%) blood donors tested positive for IgM. None of these positive IgM ELISA results was confirmed either by PRNT or by molecular tests. Conclusions: Our study has shown no evidence of recent/ongoing CHIKV infection in blood donors of the affected area

Tracking the Evolution of Written Language Competence in L2 Spanish Learners

In this paper we present an NLP-based approach for tracking the evolution of written language competence in L2 Spanish learners using a wide range of linguistic features automatically extracted from students' written productions. Beyond reporting classification results for different scenarios, we explore the connection between the most predictive features and the teaching curriculum, finding that our set of linguistic features often reflects the explicit instruction that students receive during each course

Use of a high sensitive nanofluidic array for the detection of rare copies of BCR-ABL1 transcript in patients with Philadelphia-positiveacute lymphoblastic leukemia in complete responseIlaria

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West Nile virus transmission. results from the integrated surveillance system in Italy, 2008 to 2015

IIn Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease and West Nile virus (WNV) disease) that integrates human and veterinary (animals and vectors) surveillance, is issued and revised annually according with the observed epidemiological changes. Here we describe results of the WNV integrated veterinary and human surveillance systems in Italy from 2008 to 2015. A real time data exchange protocol is in place between the surveillance systems to rapidly identify occurrence of human and animal cases and to define and update the map of affected areas i.e. provinces during the vector activity period from June to October. WNV continues to cause severe illnesses in Italy during every transmission season, albeit cases are sporadic and the epidemiology varies by virus lineage and geographic area. The integration of surveillance activities and a multidisciplinary approach made it possible and have been fundamental in supporting implementation of and/or strengthening preventive measures aimed at reducing the risk of transmission of WNV trough blood, tissues and organ donation and to implementing further measures for vector control