Listening to the headphones, hearing the city: towards an audio-visual representation of the local musicking

O presente artigo discute a utilização do audiovisual para representar as características e as possibilidades de um musicar local. Ao observar o processo de criação do documentário Um ouvido no fone e o outro na cidade, os(as) autores(as) refletem sobre os usos e as funções da música, bem como sobre o engajamento musical e a relação de escuta dos(as) riders – entregadores(as) de comida por aplicativo. Esses(as) profissionais são brasileiras e brasileiros que moram em Dublin e que têm a música como parte essencial da sua rotina de trabalho. Nesse sentido, nossa questão é: como representar as diversidades e as contradições desse musicar local? Argumentamos que, por meio das etapas coletivas de desenvolvimento e criação desse documentário, os(as) realizadores(as) expressam não apenas o engajamento dos(as) riders com a música, mas também constroem uma representação sensorial do musicar que perpassa as relações de trabalho, de afeto e de localidade.This essay discusses the use of audio-visual to represent the characteristics and possibilities of local musicking. When observing the process of creating the documentary Um ouvido no fone e o outro na cidade, the authors reflect on the uses and functions of music, as well as on the musical engagement and listening relationship of the riders – food deliverers by apps. These professionals are Brazilians who live in Dublin and who have music as an essential part of their work routine. In this sense, our question is: how to represent the diversity and contradictions of this local musicking? We argue that, through the collective stages of development and creation of this documentary, the directors express not only the engagement of the riders with the music, but also build a sensory representation of the music that runs through the relationships of work, affection and locality

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients