318 research outputs found

    A threshold secure data sharing scheme for federated clouds

    Full text link
    Cloud computing allows users to view computing in a new direction, as it uses the existing technologies to provide better IT services at low-cost. To offer high QOS to customers according SLA, cloud services broker or cloud service provider uses individual cloud providers that work collaboratively to form a federation of clouds. It is required in applications like Real-time online interactive applications, weather research and forecasting etc., in which the data and applications are complex and distributed. In these applications secret data should be shared, so secure data sharing mechanism is required in Federated clouds to reduce the risk of data intrusion, the loss of service availability and to ensure data integrity. So In this paper we have proposed zero knowledge data sharing scheme where Trusted Cloud Authority (TCA) will control federated clouds for data sharing where the secret to be exchanged for computation is encrypted and retrieved by individual cloud at the end. Our scheme is based on the difficulty of solving the Discrete Logarithm problem (DLOG) in a finite abelian group of large prime order which is NP-Hard. So our proposed scheme provides data integrity in transit, data availability when one of host providers are not available during the computation.Comment: 8 pages, 3 Figures, International Journal of Research in Computer Science 2012. arXiv admin note: text overlap with arXiv:1003.3920 by other author

    FORMULATION AND EVALUATION OF STABILIZED EPROSARTAN NANOSUSPENSION

    Get PDF
    Objective: The objective of the current study is to enhance the solubility of Eprosartan mesylate a BCS Class II drug by employing the nanoprecipitation technique. Methods: Polymeric nanoparticles of Eprosartan mesylate were prepared by precipitation technique with various polymers like PVP K30, HPMC K15M, and Eudragit L100 in various ratios. The incompatibility issues which may arise between the drug and polymers were tested by differential scanning calorimetry (DSC). The formed nanosuspensions were evaluated for various parameters like particle size, zeta potential, drug content, and dissolution testing. Results: Among all the nanosuspension formulations, E12 formulation prepared with Eudragit L 100 showed better evaluation characteristics. SEM and DSC analysis showed no major interactions with the excipients. The maximum drug release was showed at 12h. The formulation E12 showed the particle size of 81.5±5.5 nm and zeta potential of-55.1mv. Conclusion: The nano-precipitation method improved the dissolution as well as the bioavailability of Eprosartan mesylate nanosuspension

    Comparative studies on biomass of Anabaena ambigua grown in an external loop airlift photobioreactor using cross-shaped and circular sparger

    Get PDF
    126-131An external loop airlift photobioreactor of 5 litre capacity was fabricated with glass as per the design. Blue green algae Anabaena ambigua was cultured in this external loop airlift photobioreactor using cross-shaped and circular sparger. For each type of  sparger different sets of air velocities viz., 1 m/s, 1.5 m/s, 2 m/s, 2.5 m/s and 3 m/s were maintained and, once the culture reached stationary phase, the biomass was estimated by gravimetric method. For cross-shaped sparger maximum biomass was obtained at air velocity of 1.5 m/s and for circular sparger maximum biomass was obtained at air velocity of 2 m/s. Statistical analysis two-way analysis of variance (ANOVA) was performed using Microsoft Excel 2007. It was observed that there is a significant change in the biomass formed by changing the air velocity as well as changing the type of sparger. A maximum biomass of 0.809 g/L was obtained using cross-shaped sparger at air velocity of 1.5 m/s

    Formulation and evaluation of lansoprazole loaded enteric coated microspheres

    Get PDF
    The research focuses on the development of multiparticulate delivery system for acid-labile Lansoprazole to prevent its degradation in the acidic environment of the stomach and enhance its bioavailability via intestinal absorption. This problem can be solved by enteric coating. In this project, cellulose acetate phthalate a polymer usually utilized for gastrointestinal film coating of tablets, was used to prepare enteric microspheres of lansoprazole with solvent evaporation technique in various formulations such as F1, F2, F3, F4, F5 with drug: polymer ratios of 1:1, 1:2, 1:3, 1:4, 1:5 respectively. FTIR study indicated compatibility between drug and polymer. Increase in concentration of polymer increased spheriocity and mean diameter of the microspheres. The drug entrapment efficiency was in the range of 72.23% to 88.64%. SEM revealed that microspheres were found spherical and porous. In-vitro study proves that drug release slowly increases as the pH of the medium increased and prevents degradation of drug in acidic pH. In-vitro drug release was found to be 92.80%, 94.55%, 92.72%, 96.34%, 98.65% in all 5 formulations. All 5 formulations showed gastric resistance around 80-90%. So it is concluded that the developed enteric coated microspheres of Lansoprazole prevented drug release in the stomach which would lead to significant improvement in its bioavailability through enhanced intestinal absorption

    Monodromy of Cyclic Coverings of the Projective Line

    Full text link
    We show that the image of the pure braid group under the monodromy action on the homology of a cyclic covering of degree d of the projective line is an arithmetic group provided the number of branch points is sufficiently large compared to the degree.Comment: 47 pages (to appear in Inventiones Mathematicae

    MOBILE ROBOT SELF-PLANNING AND NAVIGATION BASED ON ARTIFICIAL LANDMARK LOCALIZATION METHOD AND BINOCULAR STEREO VISION

    Get PDF
    This paper describes design of artificial landmark based on colour model used for Self-planning in unstructured environment to a robot for its movement. This method provides less error in estimation when compared to existing methods. This project is an investigation into building a system which visually detects artificial landmarks to determine the landmarks within a location, decipher their position within that location and track the landmark throughout the location using Binocular stereo vision

    Neuroprotective Effects of Bikaverin on H2O2-Induced Oxidative Stress Mediated Neuronal Damage in SH-Sy5y Cell Line

    Get PDF
    The generation of free radicals and oxidative stress has been linked to several neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease, and Amyotrophic lateral sclerosis. The use of free radical scavenging molecules for the reduction of intracellular reactive oxygen species is one of the strategies used in the clinical management of neurodegeneration. Fungal secondary metabolism is a rich source of novel molecules with potential bioactivity. In the current study, bikaverin was extracted from Fusarium oxysporum f. sp. lycopersici and its structural characterization was carried out. Further, we explored the protective effects of bikaverin on oxidative stress and its anti-apoptotic mechanism to attenuate H2O2-induced neurotoxicity using human neuroblastoma SH-SY5Y cells. Our results elucidate that pretreatment of neurons with bikaverin attenuates the mitochondrial and plasma membrane damage induced by 100 µM H2O2 to 82 and 26 % as evidenced by MTT and LDH assays. H2O2 induced depletion of antioxidant enzyme status was also replenished by bikaverin which was confirmed by Realtime Quantitative PCR analysis of SOD and CAT genes. Bikaverin pretreatment efficiently potentiated the H2O2-induced neuronal markers, such as BDNF, TH, and AADC expression, which orchestrate the neuronal damage of the cell. The H2O2-induced damage to cells, nuclear, and mitochondrial integrity was also restored by bikaverin. Bikaverin could be developed as a preventive agent against neurodegeneration and as an alternative to some of the toxic synthetic antioxidants

    Modeling the Spatially Varying Water Balance Processes in a Semi- Arid Mountainous Watershed of Idaho

    Get PDF
    Mountainous watersheds in semi-arid regions are complex hydrologic systems. To critically evaluate the hydrological processes, high resolution spatio-temporal information is necessary. Also, calibrating and validating a watershed-scale model is necessary to enable our understanding of the water balance components in the gauged watersheds. The distributed Soil Water Assessment Tool (SWAT) hydrologic model was applied to a research watershed, the Dry Creek Experimental Watershed (DCEW), near Boise Idaho to investigate its water balance components both temporally and spatially. Daily streamflow data from four streamflow gauges were used for calibration and validation of the model. Monthly estimates of streamflow during the calibration phase by SWAT produced satisfactory results with a Nash Sutcliffe coefficient of model efficiency 0.79. Since it is a continuous simulation model, as opposed to an event-based model, it demonstrated the limited ability in capturing both streamflow and soil moisture for selected rain-on-snow events during the validation period between 2005-07. Our implementation of SWAT showed that seasonal and annual water balance partitioning of precipitation into evapotranspiration, streamflow, soil moisture and drainage was not only possible but closely followed the trends of a typical semiarid watershed in the intermountain west. This study highlights the necessity for better techniques to precisely identify and drive the model with commonly observed climatic inversion-related snowmelt or rain-on-snow weather events. Estimation of key parameters pertaining to soil (e.g., available water content and saturated hydraulic conductivity), snow (e.g., lapse rates, melting) and vegetation (e.g., leaf area index and maximum canopy index) using additional field observations in the watershed is critical for better prediction

    Customer-engineer relationship management for converged ICT service companies

    Get PDF
    Thanks to the advent of converged communications services (often referred to as ‘triple play’), the next generation Service Engineer will need radically different skills, processes and tools from today’s counterpart. Why? in order to meet the challenges of installing and maintaining services based on multi-vendor software and hardware components in an IP-based network environment. The converged services environment is likely to be ‘smart’ and support flexible and dynamic interoperability between appliances and computing devices. These radical changes in the working environment will inevitably force managers to rethink the role of Service Engineers in relation to customer relationship management. This paper aims to identify requirements for an information system to support converged communications service engineers with regard to customer-engineer relationship management. Furthermore, an architecture for such a system is proposed and how it meets these requirements is discussed

    Biological, antigenic and genomic relationships among the virus isolates causing mosaic disease of sugarcane in South India

    Get PDF
    The virus isolates causing mosaic disease of commercial sugarcane around Tirupati (Chittoor district, Andhra Pradesh (AP)), Tanuku (West Godavari district, AP), Hospet (Bellary district, Karnataka) and Coimbatore (Tamil Nadu) were propagated on Sorghum bicolor cv, Rio by sap inoculation and also through vegetative propagules of sugarcane. In host range studies, the four isolates infected all the 11 tested sorghum differentials with per cent infection ranging from 10 to 100, but they failed to infect Pennisetum typhoides, Zea mays, Eleusine coracana and Triticum aestivum, The antigenic relationships among these isolates determined by employing agar gel double diffusion (AGDD), direct antigen coating-enzyme-linked immunosorbent assay (DAC-ELISA) and electroblot immunoassay (EBIA) tests using antiserum of Tirupati (Chittoor district, AP) isolate (sugarcane streak mosaic virus, SCSMV-AP) revealed that the other three isolates are antigenically similar to SCSMV-AP, This was further confirmed by slot-blot hybridization using radioactive nucleic acid probe (pSV-7) specific to 3'-UTR and C-terminal portions of coat protein gene of SCSMV-AP, The heterologous isolates reacted similarly with the probe, The results demonstrated that the virus isolates causing mosaic disease of sugarcane in South Indian states are pathotypes of recently characterized SCSMV-AP, a new member of the proposed genus Tritimovirus of the family Potyviridae
    corecore