Power of the law, power to the people: pursuing innovative legal strategies in human rights advocacy

The use of legal tools and mechanisms in human rights advocacy can play a significant role in the advancement of human rights. Although often difficult, complex and time-consuming, using legal strategies, particularly strategic litigation, in campaigning and advocacy can influence decision-making processes and bring actual changes in legislation, policy and practice. It can also help raise public awareness about a particular human rights issue and empower communities to claim their rights by involving them in designing and implementing legal advocacy strategies. However, pursuing legal strategies to advance human rights is easier in some jurisdictions than in others. In countries where political space for human rights advocacy is limited and the rule of law weak, relying on human rights norms tends to be inefficient and can even prove counter-productive. In these cases, invoking other legal norms, such as environmental protection laws, can prove more useful for the improvement of the human rights situation on the ground

In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism