Meeting Physical Activity Guidelines During Pregnancy and Its Relationship With Low Back/Pelvic Girdle Pain

poste

Quantum tunneling of the interfaces between normal-metal and superconducting regions of a type-I Pb superconductor

Evidence of a non-thermal magnetic relaxation in the intermediate state of a type-I superconducor is presented. It is attributed to quantum tunneling of interfaces separating normal and superconducting regions. Tunneling barriers are estimated and temperature of the crossover from thermal to quantum regime is obtained from Caldeira-Leggett theory. Comparison between theory and experiment points to tunneling of interface segments of size comparable to the coherence length, by steps of order one nanometer

Study of CuI thin films properties for application as anode buffer layer in organic solar cells

After chemico-physical characterization of CuI thin films, the structures indium tin oxide (ITO) /CuI are systematically studied. We show that the morphology of the 3 nm thick CuI film depends on its deposition rate. To obtain smooth homogeneous CuI film, it is necessary to depose it at 0.005 nm/s. After optimization of the deposition conditions of CuI, it is shown that it behaves like a template for the organic layer. For instance, when the organic film is copper-phthalocyanine, the molecules which are usually perpendicular to the plane of the substrate lie parallel to it when deposited onto CuI. In a same way, when the electron donor is a prophyrin derivative, CuI allows to double the power conversion efficiency of the cells based on the heterojunction porphyrin/C-60. When CuI is used as anode buffer layer, it increases systematically the short circuit current, the open circuit voltage, thus the efficiency of the organic solar cell. These effects are related, not only to the improvement of the band matching between the ITO and the electron donor, but also to the templating effect of the CuI. Moreover, we show that the beneficial effect of CuI. is effective, not only with ITO, but also with fluorine doped tin oxide

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy.

Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II dose (RP2D), and dose-limiting toxicities (DLTs) of combined mTOR inhibitor sirolimus (1 mg-5 mg PO daily) and HDAC inhibitor vorinostat (100 mg-400 mg PO daily) in patients with advanced cancer. Seventy patients were enrolled and 46 (66%) were evaluable for DLT assessment since they completed cycle 1 without dose modification unless they had DLT. DLTs comprised grade 4 thrombocytopenia (n = 6) and grade 3 mucositis (n = 1). Sirolimus 4 mg and vorinostat 300 mg was declared RP2D because MTD with sirolimus 5 mg caused significant thrombocytopenia. The grade 3 and 4 drug-related toxic effects (including DLTs) were thrombocytopenia (31%), neutropenia (8%), anemia (7%), fatigue (3%), mucositis (1%), diarrhea (1%), and hyperglycemia (1%). Of the 70 patients, 35 (50%) required dose interruption or modification and 61 were evaluable for response. Partial responses were observed in refractory Hodgkin lymphoma (-78%) and perivascular epithelioid tumor (-54%), and stable disease in hepatocellular carcinoma and fibromyxoid sarcoma. In conclusion, the combination of sirolimus and vorinostat was feasible, with thrombocytopenia as the main DLT. Preliminary anticancer activity was observed in patients with refractory Hodgkin lymphoma, perivascular epithelioid tumor, and hepatocellular carcinoma

Neutralizing antibodies for venezuelan equine encephalitis virus in horses from brazilian Pantanal.

The Brazilian Pantanal hosts large concentrations of diverse wildlife species, including migratory birds, and therefore this region is potentially important for arbovirus studies in South America. Neutralizing antibodies for equine encephalitis viruses, including Eastern equine encephalitis virus (EEEV) and Western equine encephalitis virus (WEEV) have been reported in Pantanal equines.Trabalho apresentado no XXIV Congresso Brasileiro de Virologia & VIII Reunião do Mercosul de Virologia, Porto Seguro, BA. VV561