Dna-nanokoneiden esiinmarssi

DNA-nanoteknologiassa on siirrytty aikaan, jossa enää vain tutkijan mielikuvitus on rajana. Voisivatko DNA-molekyyleistä kasatut ohjelmoitavat biokoneet mullistaa lääketieteen tai toimia tietokoneen komponentteina

A modular DNA origami-based enzyme cascade nanoreactor

Peer reviewe

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

Peer reviewe

DNA origami structures as calibration standards for nanometrology

Peer reviewe

Automated design of DNA origami

Peer reviewe

Custom-shaped metal nanostructures based on DNA origami silhouettes

Peer reviewe

Nanometrology and super-resolution imaging with DNA

Peer reviewe

Raman Enhancement in Bowtie-Shaped Aperture-Particle Hybrid Nanostructures Fabricated with DNA-Assisted Lithography

We report on efficient surface-enhanced Raman spectroscopy (SERS) supporting substrates, which are based on DNA-assisted lithography (DALI) and a layered configuration of materials. In detail, we used nanoscopic DNA origami bowtie templates to form hybrid nanostructures consisting of aligned silver bowtie-shaped particles and apertures of similar shape in a silver film. We hypothesized that this particular geometry could facilitate a four-fold advantage in Raman enhancement compared to common particle-based SERS substrates, and further, we verified these hypotheses experimentally and by finite difference time domain simulations. In summary, our DALI-fabricated hybrid structures suppress the background emission, allow emission predominantly from the areas of high field enhancement, and support additional resonances associated with the nanoscopic apertures. Finally, these nanoapertures also enhance the fields associated with the resonances of the underlying bowtie particles. The versatility and parallel nature of our DNA origami-based nanofabrication scheme and all of the above-mentioned features of the hybrid structures therefore make our optically resonant substrates attractive for various SERS-based applications.Comment: 7 pages, 4 figures, Supporting Information (5 pages, 3 tables, 1 figure

DNA-Based Enzyme Reactors and Systems

Peer reviewe

Superstructure-Dependent Loading of DNA Origami Nanostructures with a Groove-Binding Drug

Peer reviewe