Extended Weyl Calculus and Application to the Phase-Space Schr\"{o}dinger Equation

We show that the Schr\"{o}dinger equation in phase space proposed by Torres-Vega and Frederick is canonical in the sense that it is a natural consequence of the extended Weyl calculus obtained by letting the Heisenberg group act on functions (or half-densities) defined on phase space. This allows us, in passing, to solve rigorously the TF equation for all quadratic Hamiltonians.Comment: To appear in J. Phys. A: Math. and genera

Online contrastive divergence with generative replay: experience replay without storing data

Conceived in the early 1990s, Experience Replay (ER) has been shown to be a successful mechanism to allow online learning algorithms to reuse past experiences. Traditionally, ER can be applied to all machine learning paradigms (i.e., unsupervised, supervised, and reinforcement learning). Recently, ER has contributed to improving the performance of deep reinforcement learning. Yet, its application to many practical settings is still limited by the memory requirements of ER, necessary to explicitly store previous observations. To remedy this issue, we explore a novel approach, Online Contrastive Divergence with Generative Replay (OCD_GR), which uses the generative capability of Restricted Boltzmann Machines (RBMs) instead of recorded past experiences. The RBM is trained online, and does not require the system to store any of the observed data points. We compare OCD_GR to ER on 9 real-world datasets, considering a worst-case scenario (data points arriving in sorted order) as well as a more realistic one (sequential random-order data points). Our results show that in 64.28% of the cases OCD_GR outperforms ER and in the remaining 35.72% it has an almost equal performance, while having a considerably reduced space complexity (i.e., memory usage) at a comparable time complexity

Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-beta1 and bax genes

BACKGROUND: Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which do not survive in ectopic locations because of programmed cell death. The aim of this study was to evaluate if the balance between cell proliferation and apoptosis is changed in eutopic endometrium from women with endometriosis throughout the menstrual cycle by studying bax (pro-apoptotic), c-myc (regulator of cell cycle) and TGF-beta1 (involved in cell differentiation) genes. METHODS: Eutopic endometrium was obtained from: 30 women with endometriosis (32.8 +/- 5 years) and 34 fertile eumenorrheic women (36 +/- 5.3 years). We analyzed apoptosis (TUNEL: DNA fragmentation); cell proliferation (immunohistochemistry (IHC) for Ki67); c-myc, bax and TGF-beta1 mRNA abundance (RT-PCR) and TGF-beta1 protein (IHC) in endometrial explants. RESULTS: Cell proliferation strongly decreased from proliferative to late secretory phases in glands, but not in stroma, in both endometria. Positive staining in glands and stroma from proliferative endometrium with endometriosis was 1.9- and 2.2-fold higher than control endometrium, respectively (p < 0.05). Abundance of c-myc mRNA was 65% higher in proliferative endometrium from endometriosis than normal tissue (p < 0.05). TGF-beta1 (mRNA and protein) augmented during mid secretory phase in normal endometrium, effect not observed in endometrium with endometriosis. In normal endometrium, the percentage of apoptotic epithelial and stromal cells increased more than 30-fold during late secretory phase. In contrast, in endometrium from endometriosis, not only this increase was not observed, besides bax mRNA decreased 63% versus normal endometrium (p < 0.05). At once, in early secretory phase, apoptotic stromal cells increased 10-fold with a concomitant augment of bax mRNA abundance (42%) in endometria from endometriosis (p < 0.05). CONCLUSION: An altered expression of c-myc, TGF-beta1 and bax was observed in eutopic endometrium from endometriosis, suggesting its participation in the regulation of cell survival in this disease. The augmented cell viability in eutopic endometrium from these patients as a consequence of a reduction in cell death by apoptosis, and also an increase in cell proliferation indicates that this condition may facilitate the invasive feature of the endometrium

Too dense to go through: The importance of low-mass clusters for satellite quenching

We study the evolution of satellite galaxies in clusters of the C-EAGLE simulations, a suite of 30 high-resolution cosmological hydrodynamical zoom-in simulations based on the EAGLE code. We find that the majority of galaxies that are quenched at $z=0$ ($\gtrsim$ 80$\%$) reached this state in a dense environment (log$_{10}$M$_{200}$[M$_{\odot}$]$\geq$13.5). At low redshift, regardless of the final cluster mass, galaxies appear to reach their quenching state in low mass clusters. Moreover, galaxies quenched inside the cluster that they reside in at $z=0$ are the dominant population in low-mass clusters, while galaxies quenched in a different halo dominate in the most massive clusters. When looking at clusters at $z>0.5$, their in-situ quenched population dominates at all cluster masses. This suggests that galaxies are quenched inside the first cluster they fall into. After galaxies cross the cluster's $r_{200}$ they rapidly become quenched ($\lesssim$ 1Gyr). Just a small fraction of galaxies ($\lesssim 15\%$) is capable of retaining their gas for a longer period of time, but after 4Gyr, almost all galaxies are quenched. This phenomenon is related to ram pressure stripping and is produced when the density of the intracluster medium reaches a threshold of $\rho_{\rm ICM}$ $\sim 3 \times 10 ^{-5}$ n$_{\rm H}$ (cm$^{-3}$). These results suggest that galaxies start a rapid-quenching phase shortly after their first infall inside $r_{200}$ and that, by the time they reach $r_{500}$, most of them are already quenched.Comment: 14 pages, 8 figures, Submitted to MNRA

Probing the innermost regions of AGN jets and their magnetic fields with RadioAstron II. Observations of 3C 273 at minimum activity

RadioAstron is a 10 m orbiting radio telescope mounted on the Spektr-R satellite, launched in 2011, performing Space Very Long Baseline Interferometry (SVLBI) observations supported by a global ground array of radio telescopes. With an apogee of about 350 000 km, it is offering for the first time the possibility to perform {\mu}as-resolution imaging in the cm-band. We present observations at 22 GHz of 3C 273, performed in 2014, designed to reach a maximum baseline of approximately nine Earth diameters. Reaching an angular resolution of 0.3 mas, we study a particularly low-activity state of the source, and estimate the nuclear region brightness temperature, comparing with the extreme one detected one year before during the RadioAstron early science period. We also make use of the VLBA-BU-BLAZAR survey data, at 43 GHz, to study the kinematics of the jet in a 1.5-year time window. We find that the nuclear brightness temperature is two orders of magnitude lower than the exceptionally high value detected in 2013 with RadioAstron at the same frequency (1.4x10^13 K, source-frame), and even one order of magnitude lower than the equipartition value. The kinematics analysis at 43 GHz shows that a new component was ejected 2 months after the 2013 epoch, visible also in our 22 GHz map presented here. Consequently this was located upstream of the core during the brightness temperature peak. These observations confirm that the previously detected extreme brightness temperature in 3C 273, exceeding the inverse Compton limit, is a short-lived phenomenon caused by a temporary departure from equipartition. Thus, the availability of interferometric baselines capable of providing {\mu}as angular resolution does not systematically imply measured brightness temperatures over the known physical limits for astrophysical sources.Comment: Accepted for publication in A&

Vortices and domain walls in a Chern-Simons theory with magnetic moment interaction

We study the structure and properties of vortices in a recently proposed Abelian Maxwell-Chern-Simons model in $2 +1$ dimensions. The model which is described by gauge field interacting with a complex scalar field, includes two parity and time violating terms: the Chern-Simons and the anomalous magnetic terms. Self-dual relativistic vortices are discussed in detail. We also find one dimensional soliton solutions of the domain wall type. The vortices are correctly described by the domain wall solutions in the large flux limit.Comment: To be published in Phys RevD 23 pages, RevTex, 5 figure

IXR '22: 1st Workshop on Interactive eXtended Reality

Despite remarkable advances, current Extended Reality (XR) applications are in their majority local and individual experiences. A plethora of interactive applications, such as teleconferencing, tele-surgery, interconnection in new buildings project chain, Cultural Heritage and Museum contents communication, are well on their way to integrate immersive technologies. However, interconnected, and interactive XR, where participants can virtually interact across vast distances, remains a distant dream. In fact, three great barriers stand between current technology and remote immersive interactive life-like experiences, namely the (i) content realism, (ii) motion-to-photon latency, and accurate (iii) human centric quality assessment and control. Overcoming these barriers will require novel solutions at all elements of the end-to-end transmission chain. This workshop focuses on the challenges, applications, and major advancements in multimedia, networks and end-user infrastructures to enable the next generation of interactive XR applications and services. The complete IXR'22 workshop proceedings are available at: https://dl.acm.org/doi/proceedings/10.1145/355248

Efficacy and safety of the combination of reduced duration prophylaxis followed by immuno-guided prophylaxis to prevent cytomegalovirus disease in lung transplant recipients (CYTOCOR STUDY): an open-label, randomised, non-inferiority clinical trial

Cytomegalovirus; Immuno-guided prophylaxis; Lung transplantationCitomegalovirus; Profilaxis inmunoguiada; Trasplante de pulmónCitomegalovirus; Profilaxi immuno-guiada; Trasplantament de pulmóINTRODUCTION: Prolonged use of antivirals to prevent the development of cytomegalovirus (CMV) disease in lung transplant patients has been shown to have significant side effects, for which alternatives are being sought to reduce their use. The monitoring of cell immunity against CMV could be an alternative as it has shown to be useful in identifying transplant patients at low risk of infection, who could benefit from shorter prophylaxis. The aim of the CYTOCOR study is to demonstrate that the combination of a reduced prophylaxis strategy with subsequent CMV-specific immunological monitoring would allow CMV infection to be controlled in lung transplant patients as effectively as the usual strategy (prophylaxis followed by pre-emptive therapy), while reducing the side effects of antivirals due to the shorter duration of prophylaxis. METHODS AND ANALYSIS: Phase III randomised, open, multicentre, parallel, non-inferiority clinical trial to study the efficacy and safety of the combination of a prophylaxis strategy up to month +3 post-transplant followed by immuno-guided prophylaxis using the QuantiFERON-CMV technique up to month +12 post-transplant to prevent CMV disease in CMV-seropositive lung transplant recipients. This strategy will be compared with a combination of a usual prophylaxis strategy up to month +6 post-transplant followed by pre-emptive therapy up to month +12. To study the incidence of CMV disease, patients will be followed up to 18 months post-transplantation. A total of 150 patients are expected to be recruited for the study. ETHICS AND PUBLIC DISSEMINATION: The clinical trial has been approved by the Research Ethics Committees and authorised by the Spanish Agency of Medicines and Medical Devices (AEMPS).If the hypothesis of this clinical trial is verified, the dissemination of the results could change clinical practice by increasing knowledge about the safety and efficacy of discontinuing valganciclovir prophylaxis in lung transplant recipients.We would like to acknowledge the support of the Spanish Network for Research in Infectious Disease (REIPI, RD16/0016), the Group for the Study of Infections in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and SCReN (Spanish Clinical Research Network) funded by the ISCIII-Sub-Directorate General for Research Assessment and Promotion through project PT13/0002/0010-PT17/0017/0012 and PT17/0017/0032

Bogomol'nyi equations for solitons in Maxwell-Chern-Simons gauge theories with the magnetic moment interaction term

Without assuming rotational invariance, we derive Bogomol'nyi equations for the solitons in the abelian Chern-Simons gauge theories with the anomalous magnetic moment interaction. We also evaluate the number of zero modes around a static soliton configuration.Comment: 9 pages, Revtex, SNUTP-94/6