Extremal Coupled Map Lattices

We propose a model for co-evolving ecosystems that takes into account two levels of description of an organism, for instance genotype and phenotype. Performance at the macroscopic level forces mutations at the microscopic level. These, in turn, affect the dynamics of the macroscopic variables. In some regions of parameter space, the system self-organises into a state with localised activity and power law distributions.Comment: 4 RevTeX pages, 3 eps figures. Uses psfig.sty. To be published in The European Physical Journal B (1999

Clover Quiz: a trivia game powered by DBpedia

Producción CientíficaDBpedia is a large-scale and multilingual knowledge base generated by extracting structured data from Wikipedia. There have been several attempts to use DBpedia to generate questions for trivia games, but these initiatives have not succeeded to produce large, varied, and entertaining question sets. Moreover, latency is too high for an interactive game if questions are created by submitting live queries to the public DBpedia endpoint. These limitations are addressed in Clover Quiz, a turn-based multiplayer trivia game for Android devices with more than 200K multiple choice questions (in English and Spanish) about different domains generated out of DBpedia. Questions are created off-line through a data extraction pipeline and a versatile template-based mechanism. A back-end server manages the question set and the associated images, while a mobile app has been developed and released in Google Play. The game is available free of charge and has been downloaded by more than 5K users since the game was released in March 2017. Players have answered more than 614K questions and the overall rating of the game is 4.3 out of 5.0. Therefore, Clover Quiz demonstrates the advantages of semantic technologies for collecting data and automating the generation of multiple choice questions in a scalable way.Ministerio de Economía, Industria y Competitividad (Projects TIN2017-85179-C3-2-R and RESET TIN2014-53199-C3-2

Synthesis of enantiomeric polyhydroxyalkylpyrrolidines from 1,3-dipolar cycloadducts. Evaluation as inhibitors of a β-galactofuranosidase

Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidines have been synthesized from the major cycloadducts obtained by the 1,3-dipolar cycloaddition of sugar enones with azomethine ylides derived from natural amino acids. Reduction of the ketone carbonyl group of the cycloadducts, which possess a basic structure of bicyclic 6-(menthyloxy)hexahydropyrano[4,3-c]pyrrol-7(6H)one, afforded a number of pyrrolidine-based bicyclic systems. A sequence of reactions, which involved hydrolysis of the menthyloxy substituent, reduction, N-protection, and degradative oxidation, afforded varied pyrrolidine structures having diverse configurations and patterns of substitution; in particular, polyhydroxylated derivatives have been obtained. The unprotected products were isolated as pyrrolidinium trifluoroacetates. Because of the furanose-like nature of the target trihydroxyalkyl pyrrolidines, these molecules have been evaluated as inhibitors of the β-galactofuranosidase from Penicillium fellutanum. The compounds showed practically no inhibitory activity for concentration of pyrrolidines in the range of 0.1–1.6 mM.Fil: Oliveira Udry, Guillermo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Repetto, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Vega, Daniel Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Varela, Oscar Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentin

Scinax granulatus (NCN). Argentina: Buenos Aires

Partido de General Pueyrredon. Sierra de Los Padres (37° 56' 25"S 57 °47' 41" W). 24 July 2010. L. E.Vega & P. J.Bellagamba. Verified by J. Faivovich. Herpetological Collection of Laboratorio Vertebrados, Departamento de Biología, Universidad Nacional de Mar del Plata (UNMdP 1809, UNMdP 1810). Two adult individuals were captured under rocks in the ridge of mountains of Sierra de los Padres of the Tandilia Mountain Range System. Another five individuals were detected inactive in similar microhabitats (under rocks). Barrasso and Cajade (Barraso, D. and R. Cajade. 2007. Geographic distribution: Scinax granulatus. Herpetol. Rev. 38: 1) pointed out that Gallardo mentioned two specimens from Sierra de la Ventana, but such citation is not supported by voucher specimens, therefore this is the first documentation of this frog inhabiting mountain environments at 170 MASL...Fil: Vega, Laura Estela. Universidad Nacional de Mar del Plata. Instituto de Biología; ArgentinaFil: Bellagamba, Patricio J.. Universidad Nacional de Mar del Plata. Instituto de Biología; ArgentinaFil: Stellatelli, Oscar Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de Mar del Plata. Instituto de Biología; ArgentinaFil: Natale, Guillermo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentin

Inhomogeneous cortical synchronization and partial epileptic seizures

Objective: Interictal synchronization clusters have recently been described in several publications using diverse techniques, including neurophysiological recordings and fMRI, in patients suffering from epilepsy. However, little is known about the role of these hypersynchronous areas during seizures. In this work, we report an analysis of synchronization clusters jointly with several network measures during seizure activity; we then discuss our findings in the context of prior literature.Methods: Subdural activity was recorded by electrocorticography (with 60 electrodesplaced at temporal and parietal lobe locations) in a patient with temporal lobe epilepsywith partial seizures with and without secondary generalization (SG). Both interictal andictal activities (during four seizures) were investigated and characterized using local synchronization and complex network methodology. The modularity, density of links, average clustering coefficient, and average path lengthswere calculated to obtain information about the dynamics of the global network. Functional connectivity changes during the seizures were compared with the time evolution of highly synchronized areas.Results: Our findings reveal temporal changes in local synchronization areas during seizuresand a tight relationship between the cortical locations of these areas and the patterns oftheir evolution over time. Seizure evolution and SG appear to be driven by two differentunderlying mechanisms.Fil: Vega Zelaya, Lorena. Hospital Universitario la Princesa; EspañaFil: Pastor, Jesús Eduardo. Hospital Universitario la Princesa; EspañaFil: García de Sola, Rafael. Hospital Universitario la Princesa; EspañaFil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentin

Modulation of brain glutamate dehydrogenase as a tool for controlling seizures

Glutamate (Glu) is a major excitatory neurotransmitter involved in epilepsy. Glu is synthesized by glutamate dehydrogenase (GDH, E.C. 1.4.1.3) and dysfunction of the enzymatic activity of GDH is associated with brain pathologies. The main goal of this work is to establish the role of GDH in the effects of antiepileptic drugs (AEDs) such as valproate (VALP), diazepam (DIAZ) and diphenylhydantoin (DPH) and its repercussions on oxygen consumption. Oxidative deamination of Glu and reductive amination of α-ketoglutarate (K) in mice brain were investigated. Our results show that AEDs decrease GDH activity and oxygen consumption in vitro. In ex vivo experiments, AEDs increased GDH activity but decreased oxygen consumption during Glu oxidative deamination. VALP and DPH reversed the increase in reductive amination of K caused by the chemoconvulsant pentylenetetrazol. These results suggest that AEDs act by modulating brain GDH activity, which in turn decreases oxygen consumption. GDH represents an important regulation point of neuronal excitability, and modulation of its activity represents a potential target for metabolic treatment of epilepsy and for the development of new AEDs

Analisis y distribucion de los bienes patrimoniales: el caso de la iglesia del siglo XIX de San Pedro en Jagué, dpto Vinchina, La Rioja-Argentina.

El presente trabajo aborda el caso de la Iglesia de San Pedro patrono de Jagüé, Departamento Vinchina, La Rioja, desde una óptica Tecno-social, analizándolo como un bien del patrimonio social de la comunidad donde está inserto. Este bien patrimonial se encuentra en estado de ruina actualmente, pero durante más dos siglos ha resultado ser el principal oratorio de la localidad citada. Por alguna causa, ha caído en desuso probablemente eclipsado por el arribo de un nuevo culto al valle: La Virgen de Andacollo. La iglesia es abordada desde su elemento base de construcción, el adobe, y a través de este elemento se realiza un diagnóstico desde lo técnico, se analiza su implicancia social y su proyección histórico-cultural en los habitantes de este pueblo de frontera. Finalmente, se aborda una serie de conclusiones en un marco coyuntural actual y se sugiere una serie de intervenciones disciplinares directas sobre el bien patrimonial de los habitantes del fronterizo Valle del Bermejo

Neurocristopathies: How new discnveries in neural crest research changed our understanding

Neural Crest Cells (NCC) have long been recognized as the fourth layer of developing vertebrate embryos. Нe neural crest is a transient cell population that is probably heterogeneous but multipotent, giving rise to melanocytes, Schwann cells, sympathetic, parasympathetic and enteric neurons, enteric glia, endocrine cells, fibroblasts, muscle, bone, cartilage and meninges, among others cell types [1]. Нe disorders that stem from neural crest dysfunction, called Neurocristopathies (NCP), are still only partially understood. Despite the great advances in our understanding of NCC formation and development, the causal link leading to NCP has remained elusive. In a recent review dealing with NCP we provided a thorough analysis of 66 NCP associated with a dozen Cell Signaling Pathways, 4 different families of transcription factors and a wide diversity of cellular processes?. In over 5 model organisms (mouse, chicken, frog, fish and others, it has been demonstrated that NCP are linked to NCC faults during essential developmental processes. We also discussed the incorporation of new diseases or syndromes based on the defects of neural crest-derived tissues and organs that have also been unveiled very recently. In the light of recent discoveries, we also included RASopathies, Ciliopathies, Ribosomopathies, and defective epigenetic mechanisms as responsible for four newly established NCP categories.Fil: Vega López, Guillermo Alfredo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentin

Visual Query Formulation for Linked Open Data: The Norwegian Entity Registry Case

The cloud of Linked Open Data is steadily growing, yet it remains largelyinaccessible to the general public, due to the technical barrier posed bythe requirement to know a formal query language such as SPARQL. Inthis article, we present a new approach for visual query formulation towardarbitrary SPARQL endpoints, and we show a working prototype developedto improve the accessibility to Linked Open Data sources for non-computerexperts. We show how the prototype can be employed to simplify access togovernmental Linked Open Data with a case study from the Norwegian EntityRegistry