Congressional Action on Resilient Infrastructure - Areas of Progress and Future Needs

Even though the 115th Congress did not enact a comprehensive infrastructure bill as many had hoped, lawmakers passed and advanced several pieces of legislation that address resilience in homes, defense facilities, airports, and water infrastructure. Going forward, resilience should be a central goal for the new construction, repair, or modernization of any infrastructure project, from early planning, budgeting, and design, through the duration of a project's life cycle. At a minimum, Congress can require resilience metrics and mitigation strategies for federally-funded projects. Prioritizing resilience in planning decisions can help meet the challenges posed by climate change-driven events, facilitate greater resource efficiency, and promote safe, healthy, and enduring infrastructure where people can thrive. Future infrastructure investments should reflect a triple bottom line of economic, social, and environmental sustainability in a manner that equitably serves the community

Audit of efficacy of CoartemTM to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up

Background; A study, which included a follow-up study, was undertaken to assess the efficacy of CoartemTM tablets (20 mg artemether and 120 mg lumefantrine – Novartis South Africa (Pty) Ltd) to clear plasmodium falciparum malaria parasitaemia at a single 42-day follow-up, with 42 days being chosen in order to detect early emergence of resistance. The study was done at Ndumo Clinic and Mosvold Hospital in the Ingwavuma District of KwaZulu-Natal, South Africa in January/February 2002. Method: The study included 37 patients presenting to Ndumo Clinic and two presenting to Mosvold Hospital with uncomplicated malaria diagnosed by symptoms and a positive immunochromographic test (ICT) for plasmodium falciparum. The main outcome measures were done using a Trophozoite count on thick film and polymerase chain reaction parasite analysis of blood spot at day 42. Results: Only 31 of the 37 recruited patients were confirmed to be suffering from malaria by polymerase chain reaction (PCR). Of the 31, 24 returned for follow-up. One patient had parasitaemia at day 33, but tested negative at day 42 after re-treatment with Coartem™. It was not determined whether this patient was suffering from a recrudescence or re-infection of falciparum malaria. All the other returning patients tested negative for falciparum malaria on blood film and PCR examination. Conclusions : CoartemTM still appears to be an effective treatment for falciparum malaria. Regular assessment of its efficacy is desirable. For full text, click here:SA Family Pract 2004;46(6): 21-2

Audit of failure rate of sulfadoxine/pyrimethamine combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up

Objective. To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine. Design. A before-after study1 Setting. Ndumo Clinic, Ingwavuma District, South Africa, October 2000 Study Group. 55 patients presenting to Ndumo clinic with uncomplicated malaria and malaria trophozoites visible on thin film. Main outcome measures:Trophozoite count on thick film at day 14. Results. 15 out of 37 patients who returned for follow-up still had trophozoites on thick film. Symptoms of most patients at day 0 and day 14 were mild, parasite counts before and after treatment were low, and trophozoites were atypical. Conclusions. There appears to be an unacceptably high day 14 failure rate with the combination of sulfadoxine/pyrimethamine and chloroquine.The mildness of symptoms, low parasite counts and atypical trophozoites suggest immunity to falciparum malaria amongst the local population. With few antimalarials to chose from, the difficult question as to future treatment of uncomplicated malaria arises. Keywords: Falciparum malaria, chloroquine, sulfadoxine, pyrimethamine SA Fam Prac Vol.25(3) 2002: 4-

Response of the Ross Ice Shelf, Antarctica, to ocean gravity-wave forcing

Author Posting. © International Glaciological Society, 2012. This article is posted here by permission of International Glaciological Society for personal use, not for redistribution. The definitive version was published in Annals of Glaciology 53 (2012): 163-172, doi:10.3189/2012AoG60A058.Comparison of the Ross Ice Shelf (RIS, Antarctica) response at near-front seismic station RIS2 with seismometer data collected on tabular iceberg B15A and with land-based seismic stations at Scott Base on Ross Island (SBA) and near Lake Vanda in the Dry Valleys (VNDA) allows identification of RIS-specific signals resulting from gravity-wave forcing that includes meteorologically driven wind waves and swell, infragravity (IG) waves and tsunami waves. The vibration response of the RIS varies with season and with the frequency and amplitude of the gravity-wave forcing. The response of the RIS to IG wave and swell impacts is much greater than that observed at SBA and VNDA. A spectral peak at near-ice-front seismic station RIS2 centered near 0.5 Hz, which persists during April when swell is damped by sea ice, may be a dominant resonance or eigenfrequency of the RIS. High-amplitude swell events excite relatively broadband signals that are likely fracture events (icequakes). Changes in coherence between the vertical and horizontal sensors in the 8-12 Hz band from February to April, combined with the appearance of a spectral peak near 10 Hz in April when sea ice damps swell, suggest that lower (higher) temperatures during austral winter (summer) months affect signal propagation characteristics and hence mechanical properties of the RIS.Support for this study for P.B. from the California Department of Boating andWaterways, US National Oceanic and Atmospheric Administration (NOAA) grant NA10OAR4310121 and US National Science Foundation grant OCE1030022 is gratefully acknowledged. Support for R.S. was provided by the Edward W. and Betty J. Scripps Chair for Excellence in Oceanography at Woods Hole Oceanographic Institution.2013-05-0

An XMM-Newton view of the `bare' nucleus of Fairall 9

We present the spectral results from a 130 ks observation, obtained from the X-ray Multi-Mirror Mission-Newton (XMM-Newton) observatory, of the type I Seyfert galaxy Fairall 9. An X-ray hardness-ratio analysis of the light-curves, reveals a `softer-when-brighter' behaviour which is typical for radio-quiet type I Seyfert galaxies. Moreover, we analyse the high spectral-resolution data of the reflection grating spectrometer and we did not find any significant evidence supporting the presence of warm-absorber in the low X-ray energy part of the source's spectrum. This means that the central nucleus of Fairall 9 is `clean' and thus its X-ray spectral properties probe directly the physical conditions of the central engine. The overall X-ray spectrum in the 0.5-10 keV energy-range, derived from the EPIC data, can be modelled by a relativistically blurred disc-reflection model. This spectral model yields for Fairall 9 an intermediate black-hole best-fit spin parameter of $\alpha=0.39^{+0.48}_{-0.30}$.Comment: Accepted for publication in MNRAS. The paper contains 11 figures and 1 tabl

The nature of the X-ray halo of the plerion G21.5-0.9 unveiled by XMM-Newton and Chandra

The nature of the radio-quiet X-ray halo around the plerionic SNR G21.5-0.9 is under debate. On the basis of spatial and spectral analysis of a large Chandra and XMM-Newton dataset of this source, we have developed a self-consistent scenario which explains all the observational features. We found that the halo is composed by diffuse extended emission due to dust scattering of X-rays from the plerion, by a bright limb which traces particle acceleration in the fast forward shock of the remnant, and by a bright spot (the ``North Spur'') which may be a knot of ejecta in adiabatic expansion. By applying a model of interaction between the PWN, the SNR and supernova environment, we argue that G21.5-0.9 progenitor may be of Type IIP or Ib/Ic, and that the remnant may be young (200-1000 yr).Comment: 11 pages, 10 figures, accepted by A&A, also avalaible at http://www.astropa.unipa.it/Library/OAPA_preprints/fb2870.ps.g

Two years of monitoring Supergiant Fast X-ray Transients with Swift

We present two years of intense Swift monitoring of three SFXTs, IGR J16479-4514, XTE J1739-302, and IGR J17544-2619 (since October 2007). Out-of-outburst intensity-based X-ray (0.3-10keV) spectroscopy yields absorbed power laws with by hard photon indices (G~1-2). Their outburst broad-band (0.3-150 keV) spectra can be fit well with models typically used to describe the X-ray emission from accreting NSs in HMXBs. We assess how long each source spends in each state using a systematic monitoring with a sensitive instrument. These sources spend 3-5% of the total in bright outbursts. The most probable flux is 1-2E-11 erg cm^{-2} s^{-1} (2-10 keV, unabsorbed), corresponding to luminosities in the order of a few 10^{33} to 10^{34} erg s^{-1} (two orders of magnitude lower than the bright outbursts). The duty-cycle of inactivity is 19, 39, 55%, for IGR J16479-4514, XTE J1739-302, and IGR J17544-2619, respectively. We present a complete list of BAT on-board detections further confirming the continued activity of these sources. This demonstrates that true quiescence is a rare state, and that these transients accrete matter throughout their life at different rates. X-ray variability is observed at all timescales and intensities we can probe. Superimposed on the day-to-day variability is intra-day flaring which involves variations up to one order of magnitude that can occur down to timescales as short as ~1ks, and whichcan be explained by the accretion of single clumps composing the donor wind with masses M_cl~0.3-2x10^{19} g. (Abridged)Comment: Accepted for publication in MNRAS. 17 pages, 11 figures, 8 table

Dental students? perspectives on three intraoral scanners and CAD/CAM systems before and after a pre-clinical elective course in digital dentistry

Intraoral scanners (IOS) are gaining interest in Dentistry for their ability to capture digital impressions of the oral cavity. These digital impressions facilitate the fabrication of indirect restorations using CAD/CAM technology. This study aimed to de

The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium

Poor oral hygiene has been proposed to contribute to head and neck cancer (HNC) risk, although causality and independency of some indicators are uncertain. This study investigates the relationship of five oral hygiene indicators with incident HNCs

Accretion, ejection and reprocessing in supermassive black holes

This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of active galactic nuclei. For a summary, we refer to the paper.Comment: White Paper in Support of the Mission Concept of the Large Observatory for X-ray Timin