Pintura, cultura e realidade

Este artigo propõe reflexões sobre a arte como área do conhecimento que estuda e propaga cultura. Por esse percurso, os cenários da modernidade e da pós-modernidade sugerem, conforme apresenta Lipovetsky (2004), o avanço da produção de subjetividade pela cultura e pelos sistemas de consumo. Esse avanço influencia os desejos e a formação dos indivíduos. Por isso, Guattari e Rolnik (1996) apresentam as ideias de individualização (esforços da produção de bens em normatizar os grupos em função do consumo) e singularização (conscientizar os indivíduos quanto às subjetividades impostas a fim de criar alternativas de vidas mais autônomas, usando como exemplo o processo artístico). Nesse sentido, expõem-se as ideias de Merleau-Ponty (2013) sobre a matéria-prima da pintura: a cultura e as relações sociais em seus respectivos contextos. Ainda, por meio das reflexões de Sabino (2018), procura-se analisar o papel da pintura como leitura da realidade. A pintura e o fazer artístico nesse cenário podem contribuir na identificação das realidades sociais como um novo processo de percepções e sensibilidades

Estudos sobre John Dewey: o estágio em Artes Visuais na Educação Infantil

O presente artigo tece relações entre experiência docente e estudos teóricos com o objetivo de analisar fundamentalmente as vivências do Estágio Curricular Supervisionado I, disciplina do curso de licenciatura em Artes Visuais da Universidade do Estado de Santa Catarina (UDESC). A atuação pedagógica decorrente da disciplina ocorreu na Educação Infantil, junto ao Núcleo de Educação Infantil Municipal (NEIM) Hassis, localizado em Florianópolis-SC. As teorias pedagógicas que influenciaram a pesquisa no estágio estão relacionadas com obras de John Dewey (1932, 1959, 1979a, 1979b) e amparadas por autores contemporâneos (CUNHA, CARVALHO), os quais promovem uma análise progressiva de algumas das teorias de Dewey em filosofia e educação

Procedimentos de coleta e manufatura na pintura contemporânea: entrevista com Silvia Carvalho

Artist Silvia Carvalho (Florianópolis-SC) collects and manufactures earth pigments, creating transformative rituals. Her work in painting demonstrates the relevance of the investigation, as it explores procedures that precede the painting itself. In this interview, Silvia Carvalho invites us to take a tour in her studio and her creative processes, especially the collect, manufacture and uses of earthy pigments, highlighting the relationship between art and life.La artista Silvia Carvalho (Florianópolis-SC) recolecta y fabrica pigmentos terrosos, creando rituales de transformación. Su trabajo en pintura demuestra la relevancia de la investigación, ya que explora procedimientos que preceden a la pintura misma. En esta entrevista, Silvia Carvalho nos invita a hacer un recorrido por su estudio y sus procesos creativos, especialmente la recolección, fabricación y usos de pigmentos terrosos, destacando la relación entre el arte y la vida.A artista Silvia Carvalho (Florianópolis-SC) realiza coletas e manufatura de pigmentos terrosos criando rituais de transformação. Seu trabalho em pintura demonstra a relevância da investigação, pois explora procedimentos que antecedem a pintura em si. Nesta entrevista, Silvia Carvalho nos convida a um passeio pelo seu ateliê e seus processos criativos, especialmente da coleta, manufatura e usos de pigmentos terrosos, evidenciando a relação entre arte e vida

Bivalency of plasminogen monoclonal antibodies is required for plasminogen bridging to fibrin and enhanced plasmin formation

Binding of plasminogen to fibrin and cell surfaces is essential for fibrinolysis and pericellular proteolysis. We used surface plasmon resonance and enzyme kinetic analyses to study the effect of two mAbs (A10.2, CPL15) on plasminogen binding and activation at fibrin surfaces. A10.2 is directed against the lysine-binding site (LBS) of kringle 4, whereas CPL15 recognises a region in kringle 1 outside the LBS. In the presence of CPL15 and A10.2 mAbs, binding of plasminogen (K(d)=1.16+/-0.22 micromol/l) to fibrin was characterised by a mAb concentration-dependent bell-shaped isotherm. A progressive increase in the concentration of mAbs at the surface was also detected, and reached a plateau corresponding to the maximum of plasminogen bound. These data indicated that at low mAb concentration, bivalent plasminogen-mAb-plasminogen ternary complexes are formed, whereas at high mAb concentration, a progressive shift to monovalent plasminogen-mAb binary complexes is observed. Plasmin formation in the presence of mAbs followed a similar bell-shaped profile. Monovalent Fab fragments of mAb A10.2 showed no effect on the binding of plasminogen, confirming the notion that a bivalent mAb interaction is essential to increase plasminogen binding and activation at the surface of fibrin

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activation of coagulation but coagulation also considerably affects inflammatory activity. The intricate relationship between inflammation and coagulation may not only be relevant for vascular atherothrombotic disease in general but has in certain clinical settings considerable consequences, for example in the pathogenesis of microvascular failure and subsequent multiple organ failure, as a result of severe infection and the associated systemic inflammatory response. Molecular pathways that contribute to inflammation-induced activation of coagulation have been precisely identified. Pro-inflammatory cytokines and other mediators are capable of activating the coagulation system and downregulating important physiological anticoagulant pathways. Activation of the coagulation system and ensuing thrombin generation is dependent on an interleukin-6-induced expression of tissue factor on activated mononuclear cells and endothelial cells and is insufficiently counteracted by physiological anticoagulant mechanisms and endogenous fibrinolysis. Interestingly, apart from the overall systemic responses, a differential local response in various vascular beds related to specific organs may occur

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

Kiri prof. M. V. G. Malacarne'le

Vassali-Eandi, Antoine Marie, 1761-1825, itaalia matemaatikMalacarne, Michele Vincenzo Giacinto, 1744-1816, itaalia meedik,anatoomia ja kirurgia professorKirjutab oma tervisest ning saadab adressaadile oma töi