Stopping manoeuvre of high speed vessels fitted with screw and waterjet propulsion

Concern about the increase in high-speed vessel traffic necessitates steps to bring out safety guidelines in order to regulate and improve their manoeuvrability. The stopping abilities of vessels ranging from medium speed containerships to high-speed vessels have been estimated. Assuming a straight contour track, the stopping distances have been checked against the known stopping criteria of IM

Analisis Pengendalian Sosial Perilaku Menyimpang Siswa Bermasalah di SMA

This research aims to determine the social control of deviant behavior troubled students at SMAN 1 Sengah Temila. It is a qualitative descriptive research. The results showed that social control has been going well but not entirely effective. It is seen from the persistence of deviant behavior that occurs as late, to the canteen outside recess, did not join the flag ceremony for no apparent reason, outside the classroom (noisier) when the teacher is not there, and truancy (small portion), not neatly dressed in school and outside of school (clothes often issued if there is no teacher who saw). Factors causing the deviant behavior of students problematic internal factors and external factors. Efforts are being made to tackle school student misbehavior problems in SMAN 1 Sengah Temila that with education, religion, advice, warning, make a statement, calling the parents and the punishment / sanctions (physical)

An experimental investigation into the constant velocity water entry of wedge-shaped sections

Constant velocity water entry is important in understanding planing and slamming of marine vessels. A test rig has been developed that drives a wedge section with end plates down guides to enter the water vertically at near constant velocity. Entry force and velocity are measured. Analysis of the test data shows that the wetting factor is about 1.6 at low deadrise angles and reduces nearly linearly to 1.3 at 451 deadrise angle. The added mass increases quadratically with immersed depth until the chines become wetted. It then continues to increase at a reducing rate, reaching a maximum value between 20% and 80% greater than at chine immersion. The flow momentum drag coefficient is estimated from the results to be 0.78 at 51 deadrise angle reducing to 0.41 at 451 deadrise angles. Constant velocity exit tests show that the momentum of the added mass is expended in driving the water above the surface level and that exit forces are low and equivalent to a drag coefficient of about 1.0-1.3. Considerable dynamic noise limits the accuracy of the results, particularly after chine immersion

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology

Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world. Many of the most common helminths establish in the gastrointestinal tract, and can exert counter-inflammatory influences on the host immune system. For these reasons, interest has arisen in how parasites may ameliorate intestinal inflammation and whether these organisms, or products they release, could offer future therapies for immune disorders. In this review, we discuss interactions between helminth parasites and the mucosal immune system, and progress made towards identifying mechanisms and molecular mediators through which it may be possible to attenuate pathology in the intestinal tract

British Asian families and the use of child and adolescent mental health services: a qualitative study of a hard to reach group

We explored attitudes to and experiences of Child and Adolescent Mental Health Services (CAMHS) among families of South Asian origin who are underrepresented as service-users in an area of a Scottish city with a high concentration of people of South Asian origin. Six community focus groups were conducted, followed by semi-structured interviews with families who had used CAMHS and with CAMHS professionals involved in those families’ cases. Lastly, parents of children who had problems usually referred to CAMHS but who had not used the service were interviewed. Qualitative analysis of transcripts and notes was undertaken using thematic and logical methods. Participants consisted of 35 adults who identified themselves as Asian and had children; 7 parents and/or the young service users him-herself; 7 health care professionals involved in the young person's care plus 5 carers of 6 young people who had not been referred to CAMHS, despite having suitable problems. Focus groups identified the stigma of mental illness and the fear of gossip as strong disincentives to use CAMHS. Families who had been in contact with CAMHS sought to minimise the stigma they suffered by emphasising that mental illness was not madness and could be cured. Families whose children had complex emotional and behavioural problems said that discrimination by health, education and social care professionals exacerbated their child's difficulties. Families of children with severe and enduring mental illness described tolerating culturally inappropriate services. Fear of gossip about children's ‘madness’ constituted a major barrier to service use for Asian families in this city. Given the widespread nature of the concern over the stigma of children's mental illness, it should be considered in designing culturally competent services for children's mental health

Prediction of load on mooring ropes of a container ship due to the forces induced by a passing bulk carrier

The hydrodynamic surge and sway forces and yaw moment on a moored ship induced by a anothership moving near and parallel to it are estimated. The results are compared with the values obtained byexperiments carried out in the Towing tank for manoeuvres in shallow water (co-operation Flanders Hydraulics -Ghent University) in Antwerp. Subsequently, equations of motion of the moored ship are solved to determine theloads on the mooring ropes. The effect of underwater form of the ships on the forces is also discussed

Modulation of innate cells by helminth infection and helminth derived products

Helminth infection affects around a quarter of people worldwide, with no effective vaccines available. Future vaccines against helminth infection will require a more precise understanding of the cellular and molecular basis of protective immunity. In addition, it is notable that the prevalence of allergic and autoimmune diseases has increased, whilst that of helminths infections has reduced. This suggested that immune responses are dampened through direct immunomodulation by helminths infections or their excretory secretory products. Based on initial observations that Heligmosomoides polygyrus excretory secretory products (HES) can improve disease scores in a chronic T cell induced colitis, we explored the role of (HES) in an innate RAG-/- CD40 colitis. We found that HES did not affect inflammatory scores and disease activity in this model of colitis, however reduced the infiltration of inflammatory cells into the peritoneum. Immunity to intestinal helminth Nippostrongylus brasiliensis and H. polygyrus requires innate and adaptive mechanisms co-ordinated through the Type 2 IL-4R/STAT6-dependent pathway. We have now found that macrophage migration inhibitory factor (MIF) is also essential for development of immunity to infection. MIF-deficient mice are slower to expel N. brasiliensis, while in wildtype animals, the expression of MIF is upregulated in macrophages in response to infection. Cellular analyses in the MIF-deficient mice demonstrate reduced recruitment of innate lymphoid cells, eosinophils and alternatively activated macrophages. Type 2 epithelial responses were reduced in the mice showing reduced tuft cell hyperplasia and almost absent RELM-ß protein in goblet cells. In order to assess if this was a developmental abnormality, we administered 4-IPP, an inhibitor of MIF to infected wild type mice. Mice receiving 4-IPP were unable to expel parasites and demonstrated similar cellular and epithelial responses as the MIF-deficient mice. IL-25 has been shown to accelerate expulsion of N.brasiliensis via the recruitment of ILC2s. Administration of rIL-25 is able to completely rescue the MIF-deficient cellular and epithelial cell phenotype. The ligands for MIF are hypothesised to be CXCR2, CXCR4 and CD74. We demonstrate that ILCs and macrophages express CXCR4. CXCR2-deficiency did not result in the epithelial cell phenotype, therefore it is unlikely that MIF is acting via CXCR2 in the gut. A deficiency of CXCR2 however, altered the immune response to N. brasiliensis in the lung with reduced alternative activation of macrophages. In parallel, we assessed the immune responses in H. polygyrus. From previous work, we know that MIF-deficient mice are less able to expel H. polygyrus primary infection, and in addition, do not mount protective secondary immune responses or protective responses to immunisation with HES. We found no difference in the percentage of Foxp3 positive T regulatory cells or HES specific antibody levels. As in the N. brasiliensis model, MIF-deficient mice produced fewer alternatively activated macrophages confirming a defect in the innate immune compartment. A microarray had previously been performed comparing BALB/c and MIF5 deficient duodenum, finding genes arl2bp, phc2 and s100a8 being downregulated in the MIF-deficient mice. In order to assess the role of S100A8 deficiency in helminths infections, we infected s100a9-/- mice in which the A8/A9 complex cannot form. We found no difference in the primary or secondary clearance of H. polygyrus suggesting that S100A8 is not important in the pathogenesis of helminths infection. ARL2BP is known to be important for STAT3 nuclear retention. We assessed STAT6 and STAT3 phosphorylation and found no difference between the BALB/c and MIF-deficient mice in phosphorylation of STAT3/6. We conclude that in Type 2 infection, MIF plays an important role in the protective Type 2 response, potentially at two levels: firstly in activation of ILCs in a manner which is upstream of, and rescued by, IL-25; and secondly in promoting alternative activation of macrophages in synergy with IL-4

Addressing design problems of the textile industry through computer aided design

Call number: LD2668 .R4 IE 1988 V37Master of ScienceIndustrial and Manufacturing Systems Engineerin