4,296 research outputs found

    Hispalis como centro de consumo desde época tardorrepublicana a la Antigüedad Tardía. El testimonio de las ánforas

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    Las excavaciones de urgencia realizadas en los últimos años en Sevilla han puesto a nuestra disposición una ingente cantidad de materiales cerámicos bien estratificados correspondientes a época romana. Las ánforas de transporte, por su potencial informativo acerca de la comercialización de productos alimenticios, constituyen una parte especialmente importante de este registro. El presente trabajo pretende caracterizar a partir de ellas el comercio en Hispalis de alimentos envasados en ánforas desde los últimos años del período republicano hasta la Antigüedad Tardía. Se esboza, de este modo, un primer esquema del comercio romano en Hispalis, atendiendo no sólo a los aspectos cualitativos del mismo (mercancías recibidas y lugares de procedencia), sino también a los cuantitativos (peso relativo de cada mercancía en cada momento y de cada una de las zonas geográficas de las que proceden los envases).Recent rescue excavations at Seville (ancient Hispalis) have provided a massive amount of well-stratifi ed ceramic materials of Roman times. Due to their informative potential for ancient trade in foodstuffs, transport amphorae are a remarkably important part of this ceramic record. Going through them, this paper aims to characterize this trade in Roman Hispalis from late republican times to Late Antiquity. A fi rst draft of roman trade in Hispalis is offered, stressing not only qualitative aspects (like the kind of imported goods and their provenance) but quantitative ones as well (relative proportion of any commodity at any time, differentiating provenance areas)

    Long-Term Hypoxia Regulates Cortisol Biosynthesis in the Ovine Fetal Adrenal Cortex

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    Previous studies demonstrated enhanced fetal adrenal cortisol biosynthesis following exposure to long-term hypoxia (LTH). The studies presented here were designed to determine the mechanism(s) regulating this important adaptive endocrine response. Ewes were maintained at high altitude (3,820 m) from approximately day 40 to 138-141 of gestation. Fetal adrenal glands were then collected from LTH and age matched normoxic controls. Dispersed fetal adrenal cortical cells (FACs) were untreated, treated with ACTH, treated in combination with ACTH precursors (POMC and 22-kDa pro-ACTH), or pre-treated with H-89 and or UO126 followed by ACTH treatment. Following ACTH treatment, cortisol biosynthesis increased in both groups but values were significantly higher in the LTH FACs. Neither basal nor ACTH-stimulated cAMP levels differed between groups. H-89 inhibition of PKA decreased cortisol to levels observed in the un-stimulated FACs in both groups. StAR protein was higher in the LTH group under un-stimulated and following ACTH treatment. ACTH precursors alone or in combination with ACTH did not affect cortisol synthesis in either group. StAR mRNA was not different between groups. Although UO126 inhibition of ERK decreased cortisol in both groups, the net decrease was greater in the LTH group in response to ACTH treatment. Basal ERK1/2, and pERK1/2 were not different between groups. In response to ACTH treatment pERK1/2 was higher in the LTH FACs, however, pERK1/2 declined significantly in normoxic control but not LTH FACs. Total ERK1/2 did not differ between groups or after ACTH treatment. UO126 significantly reduced pERK 10 to 20 fold in both groups similarly at all time points. Together with previous in vivo data, these data indicate that enhanced cortisol output in the LTH group is the result of increased adrenal ACTH sensitivity. This enhanced sensitivity is not due to differences in cAMP, PKA and or ACTH precursors. StAR, and the ERKs appear to play a key role in the enhanced cortisol response to ACTH following LTH. These adaptive responses to LTH are critical in maintaining normal fetal growth and development and these data may have important clinical implications

    Conocimiento, propiedad, participación y poder

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    La teoría organizacional ha atravesado un amplio espacio en la búsqueda de sus propias verdades apoyándose en este camino, en distintas metáforas, modelos y pensamientos. Este recorrido, o al menos un buen trecho del mismo, ha estado acompañado de reflexiones profundas y complejas en torno a cuatro palabras que se han articulado indistintamente y de dicha articulación se ha teorizado y se teorizará aún más: Conocimiento, Propiedad, Participación y Poder. Este escrito es un intento de conectar a través de un fino hilo, desde la pertinencia territorial, este eje sin ninguna pretensión adicional.The organizational theory has gone through huge space in search of his own truest supporting in this road in different metaphors, models and thoughts. This journey or at least a good part of has always been in company of deep and complex reflections around four words that have been articulated indinstinctively and of this articulation have been theorized and will be theorized even more: knowledge, property, participation and power. This writing is a purpose of connecting through a yarn edge, since territorial pertinence, this axle without an additional objective

    Economic evolution of Colombia

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    El sevillanito : sainete lírico en un acto dividido en tres cuadros : en prosa

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201
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