Use of a tyrosine kinase inhibitor as neoadjuvant therapy for non-small cell lung cancer: A case report

We report here a 66-year-old woman diagnosed with bronchioloalveolar carcinoma of the right lung cT4N2M0. The patient was from the Philippines, had never smoked, and tested positive for an EGFR mutation. She received gefitinib as neoadjuvant therapy for two months and displayed a partial response. The tumour was resected by performing a right pneumonectomy. The residual viable tumour accounted for less than 10%. Adjuvant chemotherapy with carboplatin-taxol was administered for four cycles. Fifteen months post-surgery, two brain metastases were found. Gefitinib was prescribed, and one month later complete radiological response was assessed. The patient remains asymptomatic and without visible disease four months later. Controlled randomised trials are needed to clarify the role of these target therapies in the neoadjuvant settin

Implementing the livelihood resilience framework: an indicator-based model for assessing mountain pastoral farming systems

CONTEXT: Ongoing decreases in family farms and livestock numbers in European mountain areas are linked to multiple interconnected challenges. The continuity of such farms concerns society at large since they also act as landscape stewards, and their management influences the provision of ecosystem services. The livelihood resilience lens provides a means of examining how farm households respond and build their capacity to persist, to adapt to changes and shocks, and eventually transform what is understood as farming. While an increasing number of studies address livelihood resilience in different parts of the world, its link with livelihood strategies and how these enhance or erode livelihood resilience dimensions is still missing. OBJECTIVE: We built and applied an indicator-based framework to characterize the livelihood strategies of mountain livestock farming households in the Catalan Pyrenees (Spain) considering local historical trends, to assess how these strategies contribute to their adaptive capacity. METHODS: We combined sustainable rural livelihoods and livelihood resilience frameworks and operationalized them to: group farm households with similar livelihood strategies based on their income-generating activities; asses the influence of capital assets and context on the adoption of strategies; and relate these strategies with their performance in three dimensions of adaptive capacity, namely capacity for learning and adaptation, self-organization, and diversity. Information was gathered surveying a sample of 103 farm households. RESULTS AND CONCLUSIONS: We identified five livelihood strategies showing different degrees of adaptive capacity. Farm households either intensified production (21.3% of the sample) or pursued various diversification pathways based on additional off-farm work (28.6%), rural-tourism activities (22.7%), or added-value production (13.3%). Pensioners (11.8%) had a low endowment of assets and presented the lowest estimates in several dimensions of adaptive capacity. In contrast, diversification into rural tourism scored higher in adaptive capacity, showing greater proactive capacity, farmer organization, and multiple income sources. SIGNIFICANCE: We explored the multidimensional issues that influence and are influenced by the livelihood strategies and their adaptive capacity at the farm household level. Our work highlights the relevance of including income-generating activities in addition to structural, technical, and socioeconomic variables in characterizing farming systems. It demonstrates the role of farmer involvement in formal and informal social cooperation networks in the sustainability and adaptive capacity of their households. To be successful, diversification strategies may require certain prerequisites in the farms, while strategies based on off-farm activities, although they support improved financial performance of the farm household, could also contribute to the displacement of agriculture from mountain areas

Extracting Hα\alpha flux from photometric data in the J-PLUS survey

We present the main steps that will be taken to extract H$\alpha$ emission flux from Javalambre Photometric Local Universe Survey (J-PLUS) photometric data. For galaxies with $z\lesssim0.015$, the H$\alpha$+[NII] emission is covered by the J-PLUS narrow-band filter $F660$. We explore three different methods to extract the H$\alpha$ + [NII] flux from J-PLUS photometric data: a combination of a broad-band and a narrow-band filter ($r'$ and $F660$), two broad-band and a narrow-band one ($r'$, $i'$ and $F660$), and a SED-fitting based method using 8 photometric points. To test these methodologies, we simulated J-PLUS data from a sample of 7511 SDSS spectra with measured H$\alpha$ flux. Based on the same sample, we derive two empirical relations to correct the derived H$\alpha$+[NII] flux from dust extinction and [NII] contamination. We find that the only unbiased method is the SED fitting based one. The combination of two filters underestimates the measurements of the H$\alpha$ + [NII] flux by a 28%, while the three filters method by a 9%. We study the error budget of the SED-fitting based method and find that, in addition to the photometric error, our measurements have a systematic uncertainty of a 4.3%. Several sources contribute to this uncertainty: differences between our measurement procedure and the one used to derive the spectroscopic values, the use of simple stellar populations as templates, and the intrinsic errors of the spectra, which were not taken into account. Apart from that, the empirical corrections for dust extinction and [NII] contamination add an extra uncertainty of 14%. Given the J-PLUS photometric system, the best methodology to extract H$\alpha$ + [NII] flux is the SED-fitting based one. Using this method, we are able to recover reliable H$\alpha$ fluxes for thousands of nearby galaxies in a robust and homogeneous way.Comment: 11 pages, 14 figures. Minor changes to match the published versio

Proposal of Optimal Operation in Ship Rolling Motion Considering Sea State Conditions

[Abstract] Most of the research on ship rolling motion concerns a specific type of ship, such as containerships, or analyzes sailing during certain wave characteristics, rather than the full spectrum of waves that can be encountered during the entire sea route. To date, the most frequent merchant ships in the world are general cargo ships, where the ship’s behaviour at any sea condition has a great influence on overall safety, as well as the lashing design of non-standardized cargo. For this reason, the present paper aimed to study ship-performance models, starting with concepts of the basic physics of ships and waves. Firstly, the ship’s behaviour was analyzed from a theoretical point of view, both in calm waters and when sailing in waves, but independently. Afterwards, the ship-waves system was analyzed during rolling with all variables accounted for at the same moment, with the objective of obtaining roughly realistic models. Relevant results are shown in each of the models, which may be of great interest for ship operators and, in general, for the shipping industry, so as to improve the safety of maritime transport. Finally, these results were validated with a case study. View Full-TextThis research was funded by the R&D projects (Retos y Generación de Conocimiento) of the Spanish State Plan for Scientific and Technical Research and Innovation. Reference number PID2020-119639RB-I0

P10 25. ¿Aumenta la extracción endoscópica de vena safena las complicaciones inmediatas en los pacientes coronarios?

ObjetivoEn 2009 se ha empleado en nuestro centro la extracción endoscópica de vena safena (EEVS). Analizamos si tiene un impacto inmediato en infarto perioperatorio y supervivencia.Material y métodosSe han analizado todos los pacientes coronarios aislados intervenidos en 2009. Se emplearon el Vasoview 6 y Hemopro.La duración de la intervención, estancia en unidad de cuidados intensivos (UCI), troponina postoperatoria y necesidad de aminas fueron comparadas en ambos grupos.ResultadosFueron intervenidos 291 pacientes de revascularización coronaria aislada, con un 28,5% de EEVS.Edad media 67,38 (36-83), varones 79,4%. El 47,6% fue cirugía sin bomba extracorpórea. Mortalidad global del 2,9%. Se realizaron una media de 2,64 (desviación estándar [DE] 0,904) injertos/paciente, con un tiempo total medio de quirófano de 5,83 h (DE 1,18).No precisó soporte inotrópico el 65%, y a dosis bajas en el 25,6%. Troponina máxima 0,701 (0,1-12,5). Estancia mediana en UCI 1 día (1-30).La duración de la intervención fue significativamente mayor en los pacientes con EEVS (5,68 h vs 6,41 h; p = 0,005).La troponina máxima fue ligeramente superior en el grupo de extracción convencional (0,73 vs 0,65; p = 0,667), no significativa. No hubo diferencias significativas en duración media del ingreso en UCI, ni en necesidad de soporte inotrópico.ConclusiónLa EEVS no produce repercusión precoz en cuanto a infarto perioperatorio/duración de UCI, aunque se precisa seguimiento para estimar diferencias a largo plazo.La EEVS prolonga la duración de la intervención dada su mayor complejidad técnica

Papel del logopeda en un centro gerontológico de estancias diurnas

[Resumen] El aumento de población anciana en nuestra sociedad es un hecho que ha provocado la aparición de nuevos recursos socio-sanitarios que cubran sus necesidades. El Centro Gerontológico de Estancias Diurnas es un servicio multidisciplinar diurno que se ocupa de la atención social y sanitaria, con actuación terapéutica y preventiva, de los mayores facilitando la vida laboral de las personas que se ocupan ordinariamente de su cuidado. Los centros de día deben proporcionar una atención integral debiendo, por tanto, estar constituidos por un equipo profesional multidisciplinar en el que la figura del logopeda esté presente desarrollando una labor específica. Parece, por tanto, interesante delimitar las funciones básicas a desempeñar, los trastornos más comunes susceptibles de intervención, así como, algunas directrices a tener en cuenta.[Abstract] The increase of the senior population in our society is an event that has provoked the appeareance of a new sort of social and sanitary recource, a structure that has to be concerned with the needs of this population. The gerontologic day-center is in brief a multidisciplinar service, that works during day time, treating the social and sanitary occupation of our elder with both therapeutic and preventive acts. This to provide a normal working life for the people who are usually taking care of these people. Day-centers have to answer these needs with a complete service, and for that reason they have to apile to a multidisciplinar staff in wich the speech-therapist develops a specific role. It seems though interesting to define the basic functions that a professional speech-therapist has to perform, such as the most common disorders capable of treatment and general intervention, as well derectives to bear in mind

What art can teach in industrial design: a workshop experience from the analysis of “the burial of the count of Orgaz”

La llegada del Espacio Europeo de Educación Superior ha influido en el modo de desarrollar la docencia de las disciplinas gráfcas en los estudios de Ingeniería en Diseño Industrial en nuestro país. Uno de los cambios más relevantes ha representado la implantación en las aulas del formato de taller, especialmente en las asignaturas de corte artístico; la intención última es que el alumno adquiera, de manera práctica, las competencias específcas relacionadas con su capacitación para la comunicación simbólica y la profundización en el análisis gráfco del mundo que le rodea. Este proceso obliga a una permanente síntesis de las formas, los colores y las luces de los objetos, para ser plasmados mediante las destrezas y métodos gráfcos que adquieran a lo largo de toda su vida académica. Se pretende aquí ejemplifcar este proceso con el estudio y análisis gráfco de una obra de arte, mostrando la relación existente entre el Diseño Industrial y la docencia humanística. Para ello se ha elegido la obra “El Entierro del Conde de Orgaz”, pintado por El Greco, en el que reside una gran complejidad compositiva, llena de contrastes e intencionalidad, pero a la vez enormemente didáctica desde el punto de vista plástico.The arrival of the European Higher Education Area has influenced the way to develop the teaching of the graphic disciplines in Industrial Design Engineering studies in our country. One of the most relevant changes has been the introduction of the workshop format in the classrooms, especially in artistic subjects; The ultimate intention is that the student acquires, in a practical way, the specifc competences related to his training for symbolic communication and the deepening in the graphic analysis of the world around him. This process requires a permanent synthesis of the shapes and forms, colors and lights of objects, to be captured through the skills and graphic methods acquired throughout their academic life. The aim is to exemplify this process with the study and graphic analysis of a work of art, showing the relationship between Industrial Design and humanistic teaching. For this, the work “The Burial of the Count of Orgaz”, painted by El Greco, has been chosen, in which there resides a great compositional complexity, full of contrasts and intentionality, but at the same time enormously didactic from the plastic point of view

Edge detection in continuous-range

Se presenta un método para la detección de bordes de dominio o cambios de estacionariedad en secuencias de valores de rango continuo como los obtenidos en Electromiografía (EMG) o en registros de Electroencefalograma (EEG). La detección del cambio de estacionariedad en una secuencia temporal como las mencionadas presenta interés para el reconocimiento del comienzo de una contracción muscular en EMG o del comienzo y propagación de una crisis epiléptica en el análisis del registro del EEG. El punto de segmentación en una serie temporal se corresponde con la posición en la serie a partir de la cual cambian las propiedades estadísticas de los valores que la conforman. El método aquí propuesto se basa en el cálculo de la divergencia de Jensen-Shannon (DJS) entre los segmentos que forman la secuencia. La DJS es una medida de distancia entre distribuciones de probabilidad y para su evaluación aproximamos las distribuciones que corresponden a cada segmento por el método del kernel de densidad.Para la aplicación del método se elige una posición en la secuencia como punto de segmentación y se calcula la DJS entre las distribuciones asociadas a las sub-secuencias que quedan así definidas. Se repite este proceso para cada posición en la secuencia y se identifica el punto de segmentación con la posición que arroja el valor máximo para la DJSFil: Aguirre Varela, Guillermo Gabriel. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Ré, M. A.. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: López, N. M.. Universidad Nacional de San Juan; Argentin

J-PLUS: analysis of the intracluster light in the Coma cluster

The intracluster light (ICL) is a luminous component of galaxy clusters composed of stars that are gravitationally bound to the cluster potential but do not belong to the individual galaxies. Previous studies of the ICL have shown that its formation and evolution are intimately linked to the evolutionary stage of the cluster. Thus, the analysis of the ICL in the Coma cluster will give insights into the main processes driving the dynamics in this highly complex system. Using a recently developed technique, we measure the ICL fraction in Coma at several wavelengths, using the J-PLUS unique filter system. The combination of narrow- and broadband filters provides valuable information on the dynamical state of the cluster, the ICL stellar types, and the morphology of the diffuse light. We use the Chebyshev-Fourier Intracluster Light Estimator (CICLE) to disentangle the ICL from the light of the galaxies, and to robustly measure the ICL fraction in seven J-PLUS filters. We obtain the ICL fraction distribution of the Coma cluster at different optical wavelengths, which varies from $\sim 7\%-21\%$, showing the highest values in the narrowband filters J0395, J0410, and J0430. This ICL fraction excess is distinctive pattern recently observed in dynamically active clusters (mergers), indicating a higher amount of bluer stars in the ICL compared to the cluster galaxies. Both the high ICL fractions and the excess in the bluer filters are indicative of a merging state. The presence of younger/lower-metallicity stars the ICL suggests that the main mechanism of ICL formation for the Coma cluster is the stripping of the stars in the outskirts of infalling galaxies and, possibly, the disruption of dwarf galaxies during past/ongoing mergers.Comment: 10 pages, 3 figures, 1 table. Accepted for publication in A&