Toxicidad sobre médula ósea provocada por estrógenos en la especie canina

Desde hace tiempo se conoce que los estrógenos administrados exógenamente o de procedencia endógena pueden provocar un efecto tóxico sobre la médula ósea, especialmente en la especie canina. La toxicidad está en relación con la dosis, los diferentes tipos de estrógenos, la edad del animal y también la distinta sensibilidad individual. La patogénesis de la mielotoxicidad es, en su mayor parte, desconocida. El proceso cursa invariablemente en su inicio con una hiperplasia granulocítica con leucocitosis, neutrofilia y desviación a la izquierda, con trombocitopenia y con anemia progresiva. Finalmente aparece disminución de todas las series hematopoyéticas, con hipoplasia o aplasia medular, que se refleja a nivel de la sangre con leucopenia, trombocitopenia y anemia (pancitopenia). Si bien algunos de los animales afectados pueden recuperarse una vez eliminado el agente causal, son frecuentes los casos en que se desarrolla una aplasia crónica severa e irreversible y el paciente muere debido a anemia profunda, hemorragias masivas por trombocitopenia o infecciones bacterianas secundarias con aparición de cuadros sépticos debido a la neutropema. En el presente artículo revisamos dos casos clínicos de mielotoxicidad por estrógenos, uno después de administración exógena y otro provocado por un hiperestrogenismo asociado a un tumor testicular de células de Sertoli en un macho.It is known for a long time that exogenously administered or endogenous estrogens can provoke a toxic effect on the bone marrow, particularly in the dog. Toxicity is directly correlated with the dose, the different type of estrogens, the animal age, and also the interindividual sensitivity. The pathogenesis of myelotoxicity is mostly unknown. InitiaUy, the process includes invariably a granulocytic hyperplasia and left shifted leukocytosis and neutrophilia foUowed by thrombocytopenia and progressive anemia. FinaUy, it appears a decrease of the whole hematopoietic series with a rnedullar hypoplasia or aplasia which is manifested througb a leukopenia, a thrombocytopenia and an anemia (pancytopenia). Although some of the affected animals can recover once the aethiologic agent is removed, [requently asevere and irreversible chronic aplasia can occur and the patients die due to a deep anemia, thrombocytopenia caused-masive haemorragy, or a secondary bacterial infection with septic clinical signs caused by a neutropenia. The purpose of the present article is to review two cases of estrogen toxicity, both due to exogenous administration and a hyperestrogenism associated to a testicular Sertoli cell tumor in a male

Poliartritis y leishmaniosis canina: Patogenia de la alteración articular : caso clínico

Uno de los signos clínicos a menudo observados en los perros con leishmaniosis es la presencia de cojeras, asociadas en muchos casos a poliartritis. la patogenia de estas alteraciones articulares no está del todo clara. Si bien la presencia del parásito en la articulación explicaría en muchos casos la alteración observada, debe tenerse también en cuenta el efecto patógeno que puede tener lugar a través del depósito de inmunocomplejos circulantes (ICC), que son frecuentes en esta enfermedad. En el presente artículo revisamos la bibliografía y comparamos nuestro caso con otros publicados, discutiendo sobre el posible origen de estas artropatías.Lameness, often associated with polyarthritis, is one of the most frequent clinical signs observed in dogs with leishmaniasis.The pathogenesis of these joint disturbances is not well known.Even the presence of the parasite in the joint sometimes may explain the observed alteration, the pathogenic effect triggered by the deposition of circulating immunocomplexes (CIC) that are afien produced in dogs with Cl, should also be considered.The present paper reviews the literature and compares our clinical case with others reported, thus, discussing the possible aetiology of these arthropathies

NIR surface photometry of a sample of nearby spiral galaxies

The first results of an observational programme aimed at mapping a sample of face--on spiral galaxies in the NIR are presented. This paper shows the surface photometry of the first ten galaxies in the sample. The data were taken in the broad band $J$ (1.2 $\mu$m) and $K_{s}$ (2.2 $\mu$m) filters. The sources were selected mainly according to their size and brightness in order to suit the characteristics of the CAIN 2D NIR camera on the 1.5 m Carlos S\'anchez Telescope (Tenerife, Spain). The primary scientific goal is to provide a comprehensive and uniform database of the main structural and photometric parameters of the sample members from NIR surface photometry. To this end, elliptical isophotal fitting was performed on each galaxy image to extract information about the size and location of its morphological components and provide the azimuthally averaged radial brightness profile. Analytical functions for each component's brightness distribution were then used to match that profile, and their functional parameters obtained from the global fitting. This first report includes data for NGC 3344, NGC 3686, NGC 3938, NGC 3953, NGC 4254, NGC 4303, NGC 4314, NGC 5248, NGC 6384 and NGC 7479.Comment: 9 pages and 6 figures. Accepted for publication in A&

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Poliartritis y leishmaniosis canina: Patogenia de la alteración articular : caso clínico

Uno de los signos clínicos a menudo observados en los perros con leishmaniosis es la presencia de cojeras, asociadas en muchos casos a poliartritis. la patogenia de estas alteraciones articulares no está del todo clara. Si bien la presencia del parásito en la articulación explicaría en muchos casos la alteración observada, debe tenerse también en cuenta el efecto patógeno que puede tener lugar a través del depósito de inmunocomplejos circulantes (ICC), que son frecuentes en esta enfermedad. En el presente artículo revisamos la bibliografía y comparamos nuestro caso con otros publicados, discutiendo sobre el posible origen de estas artropatías.Lameness, often associated with polyarthritis, is one of the most frequent clinical signs observed in dogs with leishmaniasis.The pathogenesis of these joint disturbances is not well known.Even the presence of the parasite in the joint sometimes may explain the observed alteration, the pathogenic effect triggered by the deposition of circulating immunocomplexes (CIC) that are afien produced in dogs with Cl, should also be considered.The present paper reviews the literature and compares our clinical case with others reported, thus, discussing the possible aetiology of these arthropathies

Magnetoresistance at artificial interfaces in the itinerant SrRuO3 ferromagnet

The magnetoresistance across interfaces in the itinerant ferromagnetic oxide SrRuO3 have been studied. To define appropriately the interfaces, epitaxial thin films have been grown on bicrystalline and laser-patterned SrTiO3 substrates. Comparison is made with results obtained on similar experiments using the double-exchange ferromagnetic oxide La2/3Sr1/3MnO3. It is found that in SrRuO3, interfaces induce a substantial negative magnetoresistance, although no traces of the low-field spin tunneling magnetoresistance are found. We discuss these results on the basis of the distinct degree of spin polarization in ruthenates and manganites and the different nature of the surface magnetic layer formed at interfaces

Preparation of Half-Sandwich Osmium Complexes by Deprotonation of Aromatic and Pro-aromatic Acids with a Hexahydride Brønsted Base

Half-sandwich osmium(II) and osmium(IV) complexes have been prepared by reaction of the hexahydride complex OsH6(PiPr3)2 (1) with phenol, pyrrole, and methylcyclopentadienes. The reaction with phenol initially leads to OsH3(OPh)(PiPr3)2 (2). In toluene, 2 undergoes reductive elimination of phenol, which tautomerizes to give OsH2(η4-2,4-cyclohexadien-1-one)(PiPr3)2 (3). The equilibrium mixture of 2 and 3 evolves into OsH(η5-PhO)(PiPr3)2 (4) with loss of molecular hydrogen. The addition of HBF4 to diethyl ether solutions of 4 leads to [OsH(η6-PhOH)(PiPr3)2]BF4 (6). The reaction of 1 with pyrrole gives OsH(η5-C4H4N)(PiPr3)2 (7), which by addition of HBF4 affords [OsH2(η5-C4H4N)(PiPr3)2]BF4 (8). Similarly, treatment of 1 with methylcyclopentadiene leads to OsH(η5-C5H4Me)(PiPr3)2 (9), which reacts with HBF4 to give [OsH2(η5-C5H4Me)(PiPr3)2]BF4 (10). Treatment of toluene solutions of 1 with tetramethylcyclopentadiene gives a mixture of the trihydride OsH3(η5-C5HMe4)(PiPr3) (11; 56%) and the dihydride-tolyl derivatives OsH2(m-tolyl)(η5-C5HMe4)(PiPr3) (12; 14%) and OsH2(p-tolyl)(η5-C5HMe4)(PiPr3) (13; 30%). However in n-octane the trihydride 11 is formed in 85% yield. In contrast to tetramethylcyclopentadiene, pentamethylcyclopentadiene reacts with 1 in toluene to give selectively the trihydride OsH3(η5-C5Me5)(PiPr3) (14). Complexes 2 and 7 have been characterized by X-ray diffraction analysis.Financial support from the MICINN of Spain (Projects CTQ2008-00810 and Consolider Ingenio 2010 CSD2007- 00006), the Departamento de Ciencia, Tecnología y Universidad del Gobierno de Aragón (E35), and the European Social Fund is acknowledged.Peer Reviewe