Estudio zoométrico realizado con ovinos de raza ripollesa

Peer Reviewe

GAEC workshop 2012 technical report

The report describes the main technical findings and results of the Good Agricultural and Environmental Condition (GAEC) workshop 2012 organised by the Joint Research Centre (JRC). The workshop was held at the JRC in Ispra from 8th-10th October 2012. 110 delegates attended the workshop representing 24 European Union Member States, two candidate countries (Croatia and Iceland) and Commission services. The workshop focussed on implementation and control issues related to the identification and measure of landscape features and buffer strips, as well as on scientific references for definition and mapping of soil related issues (e. g. soil erosion or soil organic matter). Participants also showed much interest on technical aspects related to the implementation of the future CAP with particular reference to landscape features in the framework of the so-called Ecological Focus Area. The workshop allows setting up and fine-tuning future main JRC activities taking into account DG AGRI and Member States inputs.JRC.H.4-Monitoring Agricultural Resource

Coastal warming under climate change: Global, faster and heterogeneous

Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGThe assessment of expected changes in coastal sea surface temperature (SST) on a global scale is becoming increasingly important due to the growing pressure on coastal ecosystems caused by climate change. To achieve this objective, 17 Global Climate Models from CMIP6 were used, with data from historical and hist-1950 experiments spanning 1982–2050. This analysis highlights significant warming of coastal areas worldwide, with higher and more variable rates of warming than observed in previous decades. All basins are projected to experience an increase in coastal SST near 1 °C by mid-century, with some regions exhibiting nearshore SST anomalies exceeding 2 °C for the period 2031–2050 relative to 1995–2014. Regarding the Eastern Upwelling Boundary Systems, only the Canary upwelling system and the southern part of the Humboldt upwelling system manage to show lower-than-average SST warming rates, maintaining, to a certain extent, their ability to buffer global warmingXunta de Galicia | Ref. ED431C 2021/44Xunta de Galicia | Ref. ED481B-2021-108Fundação para a Ciência e a Tecnologia | Ref. UIDP/50017/2020Fundação para a Ciência e a Tecnologia | Ref. UIDB/50017/2020Ministerio de Ciencia e Innovación y Xunta de Galicia | Ref. PRTR-C17·I1Ministerio de Ciencia e Investigación | Ref. TED2021-129524B-I0

Water-soluble vitamin insufficiency, deficiency and supplementation in children and adolescents with a psychiatric disorder: a systematic review and meta-analysis

Nutrition is fundamental for brain development, but relatively little is known about water-soluble vitamin (WSV) levels and the effect of supplementation on psychiatry symptoms in children and adolescents (CAD) with psychiatric disorders. Our team systematically reviewed all studies concerning WSV abnormalities or supplementation in CAD with any psychiatric disorder. We searched for original studies published between 1990 and 15/05/2020 which were not based on retrospective chart review and which included WSV blood level measurements or investigated the effect of WSV supplementation on psychiatric symptoms in psychiatric patients aged 18 or under. Forty-two articles were included, 69% of which (N = 29) examined Autism Spectrum Disorders (ASD), with most of these assessing folate or vitamin B12 supplementation (N = 22, 75.9% of ASD studies). Meta-analyses showed significantly lower vitamin B12 levels in ASD and ADHD patients vs. healthy controls (HC), while folate levels were higher in ADHD patients vs. HC. Most of the studies (9/10, 90%) showed a decrease in symptoms as measured by clinical scales after supplementation. There was significant heterogeneity between the studies, however many found different types of vitamin abnormalities in CAD with psychiatric disorders

A separate reality : An update on place Illusion and plausibility in virtual reality

We review the concept of presence in virtual reality, normally thought of as the sense of “being there” in the virtual world. We argued in a 2009 paper that presence consists of two orthogonal illusions that we refer to as Place Illusion (PI, the illusion of being in the place depicted by the VR) and Plausibility (Psi, the illusion that the virtual situations and events are really happening). Both are with the proviso that the participant in the virtual reality knows for sure that these are illusions. Presence (PI and Psi) together with the illusion of ownership over the virtual body that self-represents the participant, are the three key illusions of virtual reality. Copresence, togetherness with others in the virtual world, can be a consequence in the context of interaction between remotely located participants in the same shared virtual environments, or between participants and virtual humans. We then review several different methods of measuring presence: questionnaires, physiological and behavioural measures, breaks in presence, and a psychophysics method based on transitions between different system configurations. Presence is not the only way to assess the responses of people to virtual reality experiences, and we present methods that rely solely on participant preferences, including the use of sentiment analysis that allows participants to express their experience in their own words rather than be required to adopt the terminology and concepts of researchers. We discuss several open questions and controversies that exist in this field, providing an update to the 2009 paper, in particular with respect to models of Plausibility. We argue that Plausibility is the most interesting and complex illusion to understand and is worthy of significant more research. Regarding measurement we conclude that the ideal method would be a combination of a psychophysical method and qualitative methods including sentiment analysis.Postprint (published version

A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area

GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mous

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Beta-glucan; Myalgic encephalomyelitis; Vitamin B6Betaglucano; Encefalomielitis miálgica; Vitamina B6Betaglucà; Encefalomielitis miàlgica; Vitamina B6This research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 µg vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS.J.C.-M. received financial support and honoraria from Vitae Health Innovation S.L. (Montmeló, Barcelona, Spain). This study was supported by Vitae Health Innovation S.L. (Montmeló, Spain) which supplied both treatments (funding number: 2020-0445)

A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area

GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.Fil: Gelman, Diego Matias. Universidad Miguel Hernández; España. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Griveau, Amelie. Universite Paris Diderot - Paris 7; FranciaFil: Dehorter, Nathalie. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Teissier, Anne. Universite Paris Diderot - Paris 7; FranciaFil: Varela, Carolina. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Pla, Ramon. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Pierani, Alessandra. Universite Paris Diderot - Paris 7; FranciaFil: Marin, Oscar. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; Españ

Osteoarthritis:Mechanistic Insights, Senescence, and Novel Therapeutic Opportunities

Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has focused on understanding the molecular mechanisms that led to the pathogenesis of the disease, trying to identify different molecular and clinical phenotypes along with the discovery of new therapeutic opportunities. Different types of cell-to-cell communication mechanisms have been proposed to contribute to OA progression, including mechanisms mediated by connexin43 (Cx43) channels or by small extracellular vesicles. Furthermore, changes in the chondrocyte phenotype such as cellular senescence have been proposed as new contributors of the OA progression, changing the paradigm of the disease. The use of different drugs able to restore chondrocyte phenotype, to reduce cellular senescence and senescence-associated secretory phenotype components, and to modulate ion channel activity or Cx43 appears to be promising therapeutic strategies for the different types of OA. In this review, we aim to summarize the current knowledge in OA phenotypes related with aging and tissue damage and the new therapeutic opportunities currently available

Análise de Trajetórias aplicada ao Processo de Socialização de Cães-Guia

O processo de treinamento de um cão-guia é dividido em algumas etapas. A socialização é a primeira etapa da formação, na qual o animal é encaminhado à uma família socializadora. Esse artigo apresenta uma proposta para a análise de trajetórias de um cão-guia durante o processo de socialização. Por meio de um algoritmo de pré-processamento os dados brutos de trajetórias passam por um processo de limpeza e enriquecimento semântico, com a finalidade de se reduzir a quantidade de dados armazenados e agregar um maior significado sobre as atividades realizadas durante o trajeto. Ao término do pré-processamento é possível inferir a quilometragem percorrida, tempo de permanência e quantidade de paradas em certos locais, bem como os meios de transporte utilizados. Com esses indicadores busca-se determinar a qualidade da socialização e das experiências que o cão vivenciou. Por fim essas informações são disponibilizadas em um portal web, com o objetivo de facilitar a visualização dos dados.Palavras-chave: Trajetória, Cão-guia, Socialização, Análise de dados