Numerical schemes for general Klein–Gordon equations with Dirichlet and nonlocal boundary conditions

[EN]In this work, we address the problem of solving nonlinear general Klein–Gordonequations (nlKGEs). Different fourth- and sixth-order, stable explicit and implicit, finite differenceschemes are derived. These new methods can be considered to approximate all type of Klein–Gordon equations (KGEs) including phi-four, forms I, II, and III, sine-Gordon, Liouville, dampedKlein–Gordon equations, and many others. These KGEs have a great importance in engineeringand theoretical physics.The higher-order methods proposed in this study allow a reduction in the number of nodes, whichmight also be very interesting when solving multi-dimensional KGEs. We have studied the stabilityand consistency of the proposed schemes when considering certain smoothness conditions of thesolutions. Additionally, both the typical Dirichlet and some nonlocal integral boundary conditionshave been studied. Finally, some numerical results are provided to support the theoretical aspectspreviously considere

Do patients value a hospital’s innovativeness reputation? A multi-method approach to assess the relative importance of innovativeness reputation in patients’ hospital choice

Innovations in health care are costly and risky, but they also provide the opportunity for hospitals to increase quality of care, to distinguish themselves from competitors and to attract patients. While numerous hospitals strive to increase their innovativeness by adopting a costly innovation leader strategy, the question of whether this actually influences the patient’s choice remains unanswered. To understand the role of innovativeness from the patient perspective, this study conceptualizes the construct of innovativeness reputation of hospitals and determines its relevance in patients’ hospital choice decisions. In the pretest, we identified six dimensions of innovativeness reputation such as progressive work procedures and value added services. We then used three different quantitative multi-criteria decision-making methods to evaluate the relative importance of innovativeness reputation in patient choice. We collected data from 355 former German patients who had undergone elective non-emergency surgery. Overall, innovativeness reputation accounts for 11.6%–16.8% of the patient decision. Innovativeness reputation has a moderate influence on hospital choice and should be taken into account by managers. Since technical innovations are costly, hospitals should use other means to enhance their innovative image. Strategies such as emphasizing value added services can enable hospitals to increase their innovativeness reputation efficiently

The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile

The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in comparison with gluten free bread, in Non-coeliac gluten sensitivity (NCGS) patients, considering clinical/sensory parameters and gut microbiota composition. This study was performed in two phases of seven days each, comprising a basal phase with gluten free bread and an E82 phase with low-gliadin bread. Gastrointestinal clinical symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire, and stool samples were collected for gluten immunogenic peptides (GIP) determination and the extraction of gut microbial DNA. For the basal and E82 phases, seven and five patients, respectively, showed undetectable GIPs content. The bacterial 16S rRNA gene V1-V2 hypervariable regions were sequenced using the Illumina MiSeq platform and downstream analysis was done using a Quantitative Insights into Microbial Ecology (QIIME) pipeline. No significant differences in the GSRS questionnaires were observed between the two phases. However, we observed a significantly lower abundance of some gut genera Oscillospira, Dorea, Blautia, Bacteroides, Coprococcus, and Collinsella, and a significantly higher abundance of Roseburia and Faecalibacterium genera during the E82 phase compared with the basal phase. The consumption of low-gliadin bread E82 by NCGS subjects induced potentially positive changes in the gut microbiota composition, increasing the butyrate-producing bacteria and favoring a microbial profile that is suggested to have a key role in the maintenance or improvement of gut permeability.España, MINECO Projects AGL2013-48946-C3-1-R, AGL2013-48946-C and AGL2016-80566-

Aras votivas de Petavonivm

[ES] En el presente trabajo se dan a conocer tres nuevas aras romanas procedentes de Petavonium y relacionadas con el cuerpo militar, el Ala II Flavia, allí acantonado. La primera está dedicada a Némesis, la segunda probablemente a Diana y la tercera con certeza a esta misma divinidad. Las dos últimas son erigidas, respectivamente, por sendos prefectos del Ala: Tib. lunius Quadratus, conocido por una inscripción de Galicia, hoy perdida, y Amus Constans Speratianus, que aparece ahora por primera vez.[EN] In this work three new Román aras from Petavonium are presented; they are related to the army body quartered there: the Ala IIFlavia. The first one is dedicated to Nemesis, the second one probably to Diana and the third one certainly to this same divinity. The last two ones were erected, respectively, by two prefects from the Ala: Tib. lunius Quadratus, we know through one lost inscription from Galicia, and Arrius Constans Speratianus, who appears now for the first time

Retrograde Approach for Endovascular Salvage of an Infrapopliteal Vein Bypass

Producción CientíficaEndovascular treatment through femoropopliteal and infragenicular percutaneous transluminal angioplasty, both in native vessels and in bypass salvage, has been an emerging technique in recent years. However, in some cases, a difficult anterograde access in distal occlusions has limited the technical success of this procedure. Combined subintimal arterial flossing with antegradeeretrograde intervention is used as a resource technique to obtain precise recanalization in these cases. Here, we present the case of a retromalleolar access of the posterior tibial artery, based on subintimal arterial flossing with antegradeeretrograde intervention technique, to achieve femoraleposterior tibial bypass salvage

Influence of the Main Design Factors on the Optimal Fuel Cell-Based Powertrain Sizing

The design of the optimal power distribution system (PDS or powertrain) for fuel cell-based vehicles is a complex task due to PDS comprising one or more power converters, several types of secondary energy sources, a fuel cell, several control loops, and protections, among others. The optimized powertrain design tries to minimize the mass, volume, and cost, and also to improve system efficiency, fuel economy (both hydrogen and electricity), and vehicle autonomy. This paper analyzes the influence of four different factors that deeply affect the optimal powertrain design, in particular: the minimum power delivered by the fuel cell, the storage of the recovered energy from the regenerative braking periods, the battery technology, and the maximum battery state-of-charge variation. The analysis of these factors is carried out over a set of 9 different fuel cell-based architectures applied to a light vehicle, and a 10th architecture corresponding to a pure electric vehicle. This analysis provides the knowledge of how these design factors affect the mass, volume, and cost of the optimal power distribution architectures, and how they can be considered in the design.This research was funded by the Spanish Ministry of Economy and Competitiveness and ERDF, grant number DPI2014-53685-C2-1-R

Las matemáticas en la ingeniería actual: aprendizaje basado en problemas y competencias

Memoria ID-0096. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018

Tutorización británica combinada con TIC y evaluación por rúbrica

Memoria ID-083. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Sirt1 Activation With Neuroheal Is Neuroprotective But Sirt2 Inhibition With Ak7 Is Detrimental For Disconnected Motoneurons

Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury SIRT2 has been suggested to exert effects opposite those of SIRT1, however, its roles in neurodegeneration and neuron response after nerve injury remain unclear Here we compared the neuroprotective potentials of SIRT1 activation and SIRT2 inhibition in a mouse model of hypoglossal nerve axotomy This injury induced a reduction of around half MN population within the hypoglossal nucleus by a non apoptotic neurodegenerative process triggered by endoplasmic reticulum (ER) stress that resulted in activation of the unfolded protein response mediated by IREI alpha and XBP1 by 21 days post injury Both SIRT1 activation with NeuroHeal and SIRT2 inhibition with AK7 protected NSC-34 motor neuron like cells against ER stress in vitro. In agreement with the in vitro results, NeuroHeal treatment or SIRT1 overexpression was neuroprotective of axotomized hypoglossal MNs in a transgenic mouse model In contrast, AK7 treatment or SIRT2 genetic depletion in mice inhibited damaged. MN survival To resolve the in vitro/in vivo discrepancies, we used an organotypic spinal cord culture system that preserves glial cells In this system, AK7 treatment of ER stressed organotypic cultures was detrimental for MNs and increased microglial nuclear factor-kB and the consequent transcription of cytotoxic pro inflammatory factors similarly The results highlight the importance of glial cells in determining the neuroprotective impact of any treatment

Evaluación de Competencias Matemáticas en titulaciones de Ciencias e Ingeniería

Memoria ID-027. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019