The Historical Development of the Port of Livorno (Italy) and Its New Port Plan 2010 in Advanced Stage of Elaboration

The geographical location makes the port of Livorno one of the most important in Italy. The port, in fact, benefits of an extended network of roads and rails connecting it with the rest of Italy, and central and southern Europe as well. The history of Livorno and its port is inextricably linked to that of Pisa and Florence, and to the complexity of events that determined the political set-up of the region along several centuries. Looking at the new port plan of Livorno has made it necessary an extensive overview of the history of both the port, and of its planning. This analysis has allowed: to understand the reason for the different choices made in the past for the development of the port, highlighting, when necessary, the errors made; to identify the strengths and weaknesses of the existing port infrastructure; to identify the works needed to boost the port in the European context. The purpose of this paper is to provide a summary of the analysis performed for the implementation of the new Livorno port plan 2010 and show how the port planning in Italy is often conditioned by hundreds of centuries of history

Remapping heritage and the garden suburb: Haberfield's civic ecologies

© 2019, © 2019 Geographical Society of New South Wales Inc. Gardens in Australia are considered an important site of heritage maintenance and negotiation for their capacity to materialise transformations in everyday life, design, lifestyles, demographics, environment, as well as social and cultural practices. In the case of conservation areas, gardens tend to be valued in terms of their closeness and potential to preserve specific historical elements. Plants in these gardens are cultivated to evoke period designs, such as Federation (c.1890–1915) and cottage gardens. In this article we turn to gardens and gardening to make sense of entanglements between cultural, historical and environmental elements, and we ask: what role do plants play in shaping our understanding of suburban heritage? To answer this question, we draw on oral histories, archival research and ethnography in Haberfield, the first model garden suburb in Australia. We show how plants channel and mediate multiple concerns that contest and extend ideas of heritage circulating in public discourse. Foregrounding the centrality of plants, this article contributes a dynamic definition of heritage that includes the entanglement of environmental stewardship and individual and collective heritage

Value the Edge: Permaculture as Counterculture in Australia

This paper reconsiders the story of permaculture, developed in Australia in the mid-1970s by Bill Mollison and David Holmgren. This paper considers permaculture as an example of counterculture in Australia. In keeping with permaculture design ecological principles, we argue that today permaculture is best understood as part of an assemblage of design objects, bacteria, economies, humans, plants, technologies, actions, theories, mushrooms, policies, affects, desires, animals, business, material and immaterial labour and politics and that it can be read as contrapuntal rather than as oppositional practice. Contrapuntal insofar as it is not directly oppositional preferring to reframe and reorientate everyday practices. The paper is structured in three parts: in the first one we frame our argument by providing a background to our understanding of counterculture and assemblage; in the second we introduce the beginning of permaculture in its historical context, and in third we propose to consider permaculture as an assemblage

reply to the letter to the editor by C.Nicolazzo et al.: "circulating cell-free DNA and circulating tumor cells as prognostic and predictive biomarkers in advanced non-small cell lung cancer patients treated with first-line chemotherapy"

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Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.

The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders, neoplastic transformation, and tumor metastasis. We have previously demonstrated that expression of Dbl oncogene in lens epithelial cells modulates genes encoding proteins involved in epithelial-mesenchymal-transition (EMT) and induces angiogenesis in the lens. Our present study was undertaken to investigate the role of Dbl oncogene in epithelial cells transformation, providing new insights into carcinoma progression. To assess how Dbl oncogene can modulate EMT, cell migration, morphogenesis, and expression of pro-apoptotic and angiogenic factors we utilized bi- and three-dimensional cultures of MCF-10░A cells. We show that upon Dbl expression MCF-10░A cells undergo EMT. In addition, we found that Dbl overexpression sustain

Toward chemically resolved computer simulations of dynamics and remodeling of biological membranes

Cellular membranes are fundamental constituents of living organisms. Apart from defining the boundaries of the cells, they are involved in a wide range of biological functions, associated with both their structural and the dynamical properties. Biomembranes can undergo large-scale transformations when subject to specific environmental changes, including gel–liquid phase transitions, change of aggregation structure, formation of microtubules, or rupture into vesicles. All of these processes are dependent on a delicate interplay between intermolecular forces, molecular crowding, and entropy, and their understanding requires approaches that are able to capture and rationalize the details of all of the involved interactions. Molecular dynamics-based computational models at atom-level resolution are, in principle, the best way to perform such investigations. Unfortunately, the relevant spatial and time dimensionalities involved in membrane remodeling phenomena would require computational costs that are today unaffordable on a routinely basis. Such hurdles can be removed by coarse-graining the representations of the individual molecular components of the systems. This procedure anyway reduces the possibility of describing the chemical variations in the lipid mixtures composing biological membranes. New hybrid particle field multiscale approaches offer today a promising alternative to the more traditional particle-based simulations methods. By combining chemically distinguishable molecular representations with mesoscale-based computationally affordable potentials, they appear as one of the most promising ways to keep an accurate description of the chemical complexity of biological membranes and, at the same time, cover the required scales to describe remodeling events

A QoS framework for heterogeneous networking

In order for next generation networks to support effective handover procedures, there is a need for defining QoS signaling mechanisms that guarantee the provision of point- to- point as well as network level QoS. This paper proposes a QoS signaling mechanism to be implemented by the Y-Comm architecture as a potential 4G framework. The proposed mechanism requires certain level of cooperation among network elements; therefore, it proposes some functional modules/ interfaces to be run on different network entities. As showed in the paper, the proposed mechanism could be implemented in different scenarios such as initial registration and connection, and also in the case of handover

Numerical and Experimental Analysis of the Daughter Distribution in Liquid-Liquid Stirred Tanks

The drop size distributions (DSDs) of a dilute immiscible liquid-liquid mixture were measured in a fully turbulent stirred tank operating at different impeller speeds. The results were used to infer the best daughter distribution function (DDF) leading to the best reproduction of the shape of the DSD. Bell-shaped, U-shaped, M-shaped, and uniform statistical DDFs were studied, producing from two to four daughters from each breakup event. A simplified approach from the literature was adopted to solve the population balance equation that considers the spectrum of the turbulence inside the tank obtained from computational fluid dynamics simulations. The U-shaped distribution producing four fragments better reproduces the shape of the experimental DSD in the studied system

CFD-DEM characterization and population balance modelling of a dispersive mixing process

This work investigates the breakup dynamics of solid agglomerates in a polymer compounding operation, by using computational fluid dynamics (CFD) simulations together with discrete element method (DEM) simulations. CFD simulations are used to compute the flow field and the shear stress distribution inside a 2D section of a typical internal mixer for polymer compounding. DEM simulations are instead used to predict the mechanical response of the agglomerates and to detect the critical viscous shear stress needed to induce breakup. DEM breakup data and viscous stress distributions are correlated by a first–time passage–statistics and used to calibrate a population balance model. The work returned detailed insights into the flow field characteristics and into the dispersive mixing kinetics. The simulation strategy herein reported can be adapted to study generic solid–liquid disperse flows in which the breakup of the solid phase is found at the core of the system behaviour