723 research outputs found

    An Assessment of Avian Populations Within the FAP 431 Project Area, Cook, Dupage, and Will Counties, Illinois

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    Final Report, issued June, 1989Report issued on: June 1989INHS Technical Report prepared for Ilinois Department of Transportation, Bureau of Location and Environmen

    A comprehensive review of treatment options for children with attention deficit hyperactivity disorder

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    Attention Deficit Hyperactivity Disorder (ADHD), a disorder affecting between 3 and 5 percent of school-age children, manifests as a combination of three core skill deficits: inattention, hyperactivity, and impulsivity. The deficits have been found to present children with many difficulties in both home and school settings. Thus, comprehensive treatment for individuals with ADHD is of paramount importance to their development and their academic and social experiences. The content of this paper is comprised of a review of the recent research that has been published regarding the three major theoretical orientations of ADHD interventions (pharmacological, behavioral, and multimodal treatment). All of the treatment methods are discussed in terms of specific advantages and disadvantages, examples for implementation, and implications for the child, the family, and the school

    Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance

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    Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to protein adsorption. Short-chain ethylene oxide (EO) oligomers have been shown to improve the protein resistance of planar Au surfaces. We describe the application of these EO oligomers for improved protein resistance of 30 nm spherical gold nanoparticles (AuNPs). Functionalized AuNPs were characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. Capillary electrophoresis (CE) was used for separation and quantitation of AuNPs and AuNP-protein mixtures. Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen. Semi-quantitative CE analysis was carried out for mixtures of EO-functionalized AuNPs and proteins, and results demonstrated a 2.5-fold to 10-fold increase in protein binding resistance to lysozyme depending on the AuNP surface functionalization and a 15-fold increase in protein binding resistance to fibrinogen for both EO oligomers examined in this study

    A comprehensive review of treatment options for children with attention-deficit hyperactivity disorder

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    Attention Deficit Hyperactivity Disorder (ADHD), a disorder affecting between 3 and 5 percent of school-age children, manifests as a combination of three core skill deficits: inattention, hyperactivity, and impulsivity. The deficits have been found to present children with many difficulties in both home and school settings. Thus, comprehensive treatment for individuals with ADHD is of paramount importance to their development and their academic and social experiences. The content of this paper is comprised of a review of the recent research that has been published regarding the three major theoretical orientations of ADHD interventions (pharmacological, behavioral, and multimodal treatment). All of the treatment methods are discussed in terms of specific advantages and disadvantages, examples for implementation, and implications for the child, the family, and the school

    Lipid Diffusion in Tethered Bilayer Lipid Membranes (tBLMs)

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    Sex-specific but not sexually explicit: pupillary responses to dressed and naked adults

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    Dilation of the pupils is an indicator of an observer's sexual interest in other people, but it remains unresolved whether this response is strengthened or diminished by sexually explicit material. To address this question, this study compared pupillary responses of heterosexual men and women to naked and dressed portraits of male and female adult film actors. Pupillary responses corresponded with observers' self-reported sexual orientation, such that dilation occurred during the viewing of opposite-sex people, but were comparable for naked and dressed targets. These findings indicate that pupillary responses provide a sex-specific measure, but are not sensitive to sexually explicit content

    Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes

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    Surface-tethered biomimetic bilayer membranes (tethered bilayer lipid membranes (tBLMs)) were formed on gold surfaces from phospholipids and a synthetic 1-thiahexa(ethylene oxide) lipid, WC14. They were characterized using electrochemical impedance spectroscopy, neutron reflection (NR), and Fourier-transform infrared reflection-absorption spectroscopy (FT-IRRAS) to obtain functional and structural information. The authors found that electrically insulating membranes (conductance and capacitance as low as 1 microS cm(-2) and 0.6 microF cm(-2), respectively) with high surface coverage (>95% completion of the outer leaflet) can be formed from a range of lipids in a simple two-step process that consists of the formation of a self-assembled monolayer (SAM) and bilayer completion by "rapid solvent exchange." NR provided a molecularly resolved characterization of the interface architecture and, in particular, the constitution of the space between the tBLM and the solid support. In tBLMs based on SAMs of pure WC14, the hexa(ethylene oxide) tether region had low hydration even though FT-IRRAS showed that this region is structurally disordered. However, on mixed SAMs made from the coadsorption of WC14 with a short-chain "backfiller," beta-mercaptoethanol, the submembrane spaces between the tBLM and the substrates contained up to 60% exchangeable solvent by volume, as judged from NR and contrast variation of the solvent. Complete and stable "sparsely tethered" BLMs (stBLMs) can be readily prepared from SAMs chemisorbed from solutions with low WC14 proportions. Phospholipids with unsaturated or saturated, straight or branched chains all formed qualitatively similar stBLMs.This work was supported by the National Science Foundation CBET-0555201 and 0457148. One of the authors M.L. and the AND/R instrument were supported by the National Institutes of Health under Grant No. 1 R01 RR14812 and by the Regents of the University of California
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