A kinematically enhanced constitutive model for progressive damage analysis of unidirectional fiber reinforced composites

The application of fiber reinforced laminated composite structures has been increasing steadily in many engineering disciplines due to their high specific strength and stiffness, corrosion resistance, exceptional durability and many other attractive features over the last few decades. A comprehensive strength and failure assessment of these structures made of composite materials is extremely important for a reliable design of these structures and it has been a major focus of many researchers in this field for a long time. To the best of our knowledge, the majority of the existing studies based on macro based continuum approach are particularly focussed on capturing the effective elastic properties and final failure envelop of the composite material, while the subsequent post-yield inelastic behaviour or the entire nonlinear response is often overlooked. Composite structures with such diverse applications can be subjected to complex loading conditions such as impacts, severe dynamic loads or extreme thermal loads which can lead to a significant damage or complete failure of these structures. It is therefore essential to predict the entire nonlinear response and failure of these structures in many situations for a better design with higher confidence. This problem is quite challenging, specifically with a macro based continuum approach, as the actual failure initiates at the micro scale in the form of matrix cracking, fiber rupture or fiber-matrix interface failure which propagate gradually, accumulate together and finally manifested as macroscale structural failure. Thus tracking the details on the entire failure evolution process from microscale to macroscale is necessary for accurately modelling the structural failure. A detailed micromechanical modelling approach, where all constituents are explicitly modelled, can capture all these microscale failure processes and their evolutions in details but such modelling strategy is not computationally feasible for failure analysis for large structures due to a huge gap between micro/fiber and macro/structural scales. Thus the analysis of these structures requires an innovative modelling approach that can represent and capture the essential features of these microscale failure details, while at the same time, should be computationally efficient like a macro based continuum model for undertaking large scale structural analysis. In this study, a new three-dimensional kinematically enhanced macro-based constitutive model is developed which is applicable at the lamina/ply scale of these laminated composite structures. A novel analytical technique is developed for upscaling the nonlinear response from the fiber/micro scale to the ply scale which is the key for achieving such precise modelling of composites with feasible computational resources. The proposed approach utilized a strategy of strain field enhancements kinematically to account for different rate of deformations in the local fields within a fiber reinforced composite (FRC) ply. Based on these considerations, closed-form analytical expressions are derived which can be used conveniently to express the average macro strain increments of the entire volume element in terms of strain increments in the local fields and vice versa. This modelling strategy provides an opportunity to incorporate both fiber and matrix constitutive responses as well as their interactions into the overall ply response. To this end, a thermodynamics-based continuum model is developed using damage mechanics and plasticity theory to capture the constitutive response of the matrix. This has incorporated two predominant failure mechanisms in the matrix, which are permanent plastic deformation and loss of stiffness. For the fiber-matrix interface that includes interfacial debonding, an anisotropic damage model is developed to account for the directional dependence of the softening response in FRC ply due to fiber debonding failure. The proposed approach and models are developed in incremental forms, allowing the applications in both linear and nonlinear ranges of behaviour. Their verification with available analytical and numerical approaches together with the validation against a wide range of experimental data show both features and good potentials of the proposed approach.Thesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Civil, Environmental and Mining Engineering, 201

The Role of Bacillithiol in Gram-Positive Firmicutes

Significance: Since the discovery and structural characterization of bacillithiol (BSH), the biochemical functions of BSH-biosynthesis enzymes (BshA/B/C) and BSH-dependent detoxification enzymes (FosB, Bst, GlxA/B) have been explored in Bacillus and Staphylococcus species. It was shown that BSH plays an important role in detoxification of reactive oxygen and electrophilic species, alkylating agents, toxins, and antibiotics. Recent Advances: More recently, new functions of BSH were discovered in metal homeostasis (Zn buffering, Fe-sulfur cluster, and copper homeostasis) and virulence control in Staphylococcus aureus. Unexpectedly, strains of the S. aureus NCTC8325 lineage were identified as natural BSH-deficient mutants. Modern mass spectrometry-based approaches have revealed the global reach of protein S-bacillithiolation in Firmicutes as an important regulatory redox modification under hypochlorite stress. S-bacillithiolation of OhrR, MetE, and glyceraldehyde-3-phosphate dehydrogenase (Gap) functions, analogous to S-glutathionylation, as both a redox-regulatory device and in thiol protection under oxidative stress. Critical Issues: Although the functions of the bacilliredoxin (Brx) pathways in the reversal of S-bacillithiolations have been recently addressed, significantly more work is needed to establish the complete Brx reduction pathway, including the major enzyme(s), for reduction of oxidized BSH (BSSB) and the targets of Brx action in vivo. Future Directions: Despite the large number of identified S-bacillithiolated proteins, the physiological relevance of this redox modification was shown for only selected targets and should be a subject of future studies. In addition, many more BSH-dependent detoxification enzymes are evident from previous studies, although their roles and biochemical mechanisms require further study. This review of BSH research also pin-points these missing gaps for future research. Antioxid. Redox Signal. 28, 445–462

Evaluating the impacts of rice-based protection dykes on floodwater dynamics in the vietnamese mekong delta using geographical impact factor (Gif)

This study aims at evaluating the geographical influences of rice-based protection dykes on floodwater regimes along the main rivers, namely the Mekong and the Bassac, in the Vietnamese Mekong Delta (VMD). Specifically, numerous low dykes and high dykes have been constructed particularly in the upper delta’s floodplains to protect the double and triple rice cropping against the annual flooding. For the whole deltaic domain, a 1D-quasi-2D hydrodynamic model setup was used to simulate seventy-two (72) scenarios of dyke construction development in the context of low, medium, and high floods that occurred in the VMD to examine the effects of different flood magnitudes on a certain dyke construction area. Based on the model simulation results, we established an evaluation indicator, the so-called Geographical Impact Factor (GIF), to evaluate the impacts of zone-based dyke compartments on the floodwater regimes along the main rivers for different kinds of floods. Our findings revealed different rates of influences on the floodwater levels along the Mekong and Bassac Rivers under different scenarios of zone-based high-dyke developments. GIF is a useful index for scientists and decision-makers in land use planning, especially in rice intensification, in conjunction with flood management for the VMD and for similar deltas worldwide

Интеллектуальная радиосеть с нечеткой конфигурацией

В статье обсуждаются возможности применения одноранговой радиосети стандарта IEEE 802.15.4 (ZigBee) диапазона 2,4 ГГц для работы системы, состоящей из группы малогабаритных мобильных роботов и одного командного пункта. Основная задача группы роботов – проведение разведки во время спасательных операций после техногенных и природных катастроф и аварий. Для сохранения управляемости отдельными роботами и системой в целом предлагается повысить «интеллект» системы связи за счет гибкой маршрутизации каналов между командным пунктом и конкретным мобильным роботом с тем, чтобы иметь систему с автоматическим, интеллектуальным восстановлением канала обмена данных.У статті обговорюються можливості застосування однорангової радіомережі стандарту ІЕЕ 802.15.4 (ZigBee) діапазону 2,4 Ггу для роботи системи, що складається з групи малогабаритних мобільних роботів та одного командного пункту. Основна задача групи роботів – проведення розвідки під час рятувальних операцій після техногенних та природних катастроф і аварій. Для збереження керованості окремими ротами та системою в цілому пропонується підвищити інтелект системи зв’язку за рахунок гнучкої маршрутитизації каналів між командним пунктом та конкретним мобільним роботом з тим, щоб мати систему з автоматичним, інтелектуальним відновлюванням каналу обміну даних.In the article the possibilities of application peer-to-peer radio networks of standard IEEE 802.15.4 (ZigBee) a range of 2,4 GHz for work of the system consisting of small-sized mobile robots group and one command point are discussed. The primary goal of group of robots – is carrying out of investigation during rescue operations after technogenic and natural accidents and failures. For controllability preservation by separate robots and system as a whole, it is offered to raise “intelligence” of a communication system at the expense of flexible routeing of channels between command point and the concrete mobile robot to have system with automatic, intellectual restoration of the channel of data exchange

Commensurate and Incommensurate Vortex States in Superconductors with Periodic Pinning Arrays

As a function of applied field, we find a rich variety of ordered and partially-ordered vortex lattice configurations in systems with square or triangular arrays of pinning sites. We present formulas that predict the matching fields at which commensurate vortex configurations occur and the vortex lattice orientation with respect to the pinning lattice. Our results are in excellent agreement with recent imaging experiments on square pinning arrays [K. Harada et al., Science 274, 1167 (1996)].Comment: 9 pages, 3 figures. Accepted to Physical Review

Vanishing Twist near Focus-Focus Points

We show that near a focus-focus point in a Liouville integrable Hamiltonian system with two degrees of freedom lines of locally constant rotation number in the image of the energy-momentum map are spirals determined by the eigenvalue of the equilibrium. From this representation of the rotation number we derive that the twist condition for the isoenergetic KAM condition vanishes on a curve in the image of the energy-momentum map that is transversal to the line of constant energy. In contrast to this we also show that the frequency map is non-degenerate for every point in a neighborhood of a focus-focus point.Comment: 13 page

Estimation of methane emissions from local and crossbreed beef cattle in Daklak province of Vietnam

Objective: This study was aimed at evaluating effects of cattle breed resources and alternative mixed-feeding practices on meat productivity and emission intensities from household farming systems (HFS) in Daklak Province, Vietnam. Methods: Records from Local Yellow×Red Sindhi (Bos indicus; Lai Sind) and 1/2 Limousin, 1/2 Drought Master, and 1/2 Red Angus cattle during the growth (0 to 21 months) and fattening (22 to 25 months) periods were used to better understand variations on meat productivity and enteric methane emissions. Parameters were determined by the ruminant model. Four scenarios were developed: (HFS1) grazing from birth to slaughter on native grasses for approximately 10 h plus 1.5 kg dry matter/d (0.8% live weight [LW]) of a mixture of Guinea grass (19%), cassava (43%) powder, cotton (23%) seed, and rice (15%) straw; (HFS2) growth period fed with elephant grass (1% of LW) plus supplementation (1.5% of LW) of rice bran (36%), maize (33%), and cassava (31%) meals; and HFS3 and HFS4 computed elephant grass, but concentrate supplementation reaching 2% and 1% of LW, respectively. Results: Results show that compared to HFS1, emissions (72.3±0.96 kg CH 4 /animal/life; least squares means± standard error of the mean) were 15%, 6%, and 23% lower (p < 0.01) for the HFS2, HFS3, and HFS4, respectively. The predicted methane efficiencies (CO 2 eq) per kg of LW at slaughter (4.3±0.15), carcass weight (8.8±0.25 kg) and kg of edible protein (44.1±1.29) were also lower (p < 0.05) in the HFS4. In particular, irrespective of the HSF, feed supply and ratio changes had a more positive impact on emission intensities when crossbred 1/2 Red Angus cattle were fed than in their crossbred counterparts. Conclusion: Modest improvements on feeding practices and integrated modelling frameworks may offer potential trade-offs to respond to climate change in Vietnam

Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis

Linezolid is a promising antimicrobial agent for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its use is limited by toxicity. Therapeutic drug monitoring (TDM) may help to minimize toxicity while adequate drug exposure is maintained. Conventional plasma sampling and monitoring might be hindered in many parts of the world by logistical problems that may be solved by dried blood spot (DBS) sampling. The aim of this study was to develop and validate a novel method for TDM of linezolid in MDR-TB patients using DBS sampling. Plasma, venous DBS, and capillary DBS specimens were obtained simultaneously from eight patients receiving linezolid. A DBS sampling method was developed and clinically validated by comparing DBS with plasma results using Passing-Bablok regression and Bland-Altman analysis. This study showed that DBS analysis was reproducible and robust. Accuracy and between- and within-day precision values from three validations presented as bias and coefficient of variation (CV) were less than 17.2% for the lower limit of quantification and less than 7.8% for other levels. The method showed a high recovery of approximately 95% and a low matrix effect of less than 8.7%. DBS specimens were stable at 37 degrees C for 2 months and at 50 degrees C for 1 week. The ratio of the concentration of linezolid in DBS samples to that in plasma was 1.2 (95% confidence interval [CI], 1.12 to 1.27). Linezolid exposure calculated from concentrations DBS samples and plasma showed good agreement. In conclusion, DBS analysis of linezolid is a promising tool to optimize linezolid treatment in MDR-TB patients. An easy sampling procedure and high sample stability may facilitate TDM, even in underdeveloped countries with limited resources and where conventional plasma sampling is not feasible