2,336 research outputs found
Spatial and kinematic alignments between central and satellite halos
Based on a cosmological N-body simulation we analyze spatial and kinematic
alignments of satellite halos within six times the virial radius of group size
host halos (Rvir). We measure three different types of spatial alignment: halo
alignment between the orientation of the group central substructure (GCS) and
the distribution of its satellites, radial alignment between the orientation of
a satellite and the direction towards its GCS, and direct alignment between the
orientation of the GCS and that of its satellites. In analogy we use the
directions of satellite velocities and probe three further types of alignment:
the radial velocity alignment between the satellite velocity and connecting
line between satellite and GCS, the halo velocity alignment between the
orientation of the GCS and satellite velocities and the auto velocity alignment
between the satellites orientations and their velocities. We find that
satellites are preferentially located along the major axis of the GCS within at
least 6 Rvir (the range probed here). Furthermore, satellites preferentially
point towards the GCS. The most pronounced signal is detected on small scales
but a detectable signal extends out to 6 Rvir. The direct alignment signal is
weaker, however a systematic trend is visible at distances < 2 Rvir. All
velocity alignments are highly significant on small scales. Our results suggest
that the halo alignment reflects the filamentary large scale structure which
extends far beyond the virial radii of the groups. In contrast, the main
contribution to the radial alignment arises from the adjustment of the
satellite orientations in the group tidal field. The projected data reveal good
agreement with recent results derived from large galaxy surveys. (abridged)Comment: accepted for publication in Ap
Age determination of the HR8799 planetary system using asteroseismology
Discovery of the first planetary system by direct imaging around HR8799 has
made the age determination of the host star a very important task. This
determination is the key to derive accurate masses of the planets and to study
the dynamical stability of the system. The age of this star has been estimated
using different procedures. In this work we show that some of these procedures
have problems and large uncertainties, and the real age of this star is still
unknown, needing more observational constraints. Therefore, we have developed a
comprehensive modeling of HR8799, and taking advantage of its gamma
Doradus-type pulsations, we have estimated the age of the star using
asteroseismology. The accuracy in the age determination depends on the rotation
velocity of the star, and therefore an accurate value of the inclination angle
is required to solve the problem. Nevertheless, we find that the age estimate
for this star previously published in the literature ([30,160] Myr) is
unlikely, and a more accurate value might be closer to the Gyr. This
determination has deep implications on the value of the mass of the objects
orbiting HR8799. An age around 1 Gyr implies that these objects are
brown dwarfs.Comment: 5 pages, 3 figures, accepted in MNRAS Letter
Unicentric castleman's disease located in the lower extremity: a case report
<p>Abstract</p> <p>Background</p> <p>Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and multicentric Castleman's disease are being distinguished, the latter harboring an unfavorable prognosis.</p> <p>Case Presentation</p> <p>Here, we present a case of unicentric Castleman's disease in a 37-year-old woman without associated neoplastic, autoimmune or infectious diseases. The lesion was located in the femoral region of the right lower extremity and surgically resected after radiographic workup and excisional biopsy examinations. The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis, onion-skinning and rich interfollicular vascularization. CD23-positive follicular dendritic cells were detected in the germinal centers and numerous CD138-positive plasma cells in interfollicular areas. The diagnosis of mixed cellularity type Castleman's disease was established and the patient recovered well.</p> <p>Conclusions</p> <p>In conclusion, the differential diagnosis of Castleman's disease should be considered when evaluating a sharply demarcated, hypervascularized lymphatic tumor located in the extremities. However, the developmental etiology of Castleman's disease remains to be further examined.</p
Astrometry with Hubble Space Telescope: A Parallax of the Fundamental Distance Calibrator RR Lyrae
We present an absolute parallax and relative proper motion for the
fundamental distance scale calibrator, RR Lyr. We obtain these with astrometric
data from FGS 3, a white-light interferometer on HST. We find mas. Spectral classifications and VRIJHKTM and DDO51 photometry of
the astrometric reference frame surrounding RR Lyr indicate that field
extinction is low along this line of sight. We estimate =0.07\pm0.03 for
these reference stars. The extinction suffered by RR Lyr becomes one of the
dominant contributors to the uncertainty in its absolute magnitude. Adopting
the average field absorption, =0.07 \pm 0.03, we obtain M_V^{RR} = 0.61
^{-0.11}_{+0.10}. This provides a distance modulus for the LMC, m-M = 18.38 -
18.53^{-0.11}_{+0.10} with the average extinction-corrected magnitude of RR Lyr
variables in the LMC, , remaining a significant uncertainty. We compare
this result to more than 80 other determinations of the distance modulus of the
LMC.Comment: Several typos corrected. To appear in The Astronomical Journal,
January 200
Does Changing Inhaler Device Impact Real-Life Asthma Outcomes? : Clinical and Economic Evaluation
This study was funded by Mundipharma Korea Limited (Seoul, Korea).Peer reviewedPostprin
HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure
In a recent summary of integrase sequences, primary integrase inhibitor mutations were rare. In a review of integrase inhibitor-naĂŻve Australian HIV-1 sequences, primary mutations were not identified, although the accessory mutation G140S was detected. A link with previous antiretroviral therapy, intra-subtype B divergence across the integrase gene and transmission of integrase polymorphisms were also noted. Based on these findings, we would recommend ongoing surveillance of integrase mutations, and integrase region sequencing for patients prior to commencement of integrase inhibitors
Target selection for the SUNS and DEBRIS surveys for debris discs in the solar neighbourhood
Debris discs - analogous to the Asteroid and Kuiper-Edgeworth belts in the
Solar system - have so far mostly been identified and studied in thermal
emission shortward of 100 um. The Herschel space observatory and the SCUBA-2
camera on the James Clerk Maxwell Telescope will allow efficient photometric
surveying at 70 to 850 um, which allow for the detection of cooler discs not
yet discovered, and the measurement of disc masses and temperatures when
combined with shorter wavelength photometry. The SCUBA-2 Unbiased Nearby Stars
(SUNS) survey and the DEBRIS Herschel Open Time Key Project are complimentary
legacy surveys observing samples of ~500 nearby stellar systems. To maximise
the legacy value of these surveys, great care has gone into the target
selection process. This paper describes the target selection process and
presents the target lists of these two surveys.Comment: 67 pages with full tables, 7 figures, accepted to MNRA
Barriers and facilitators to self-management of asthma in adolescents:an interview study to inform development of a novel intervention
BACKGROUND AND OBJECTIVE: Despite literature that spans twenty years describing the barriers to asthma self-management in adolescents, successful, clinically-based interventions to address this important issue are lacking. Given the limitations of some of the previous studies, we conducted a study that aimed to gain a broader insight into barriers and facilitators to self-management of asthma by adolescents, not just adherence to treatment, and triangulated their views with those of their parents and healthcare professionals. METHODS: Focus groups and interviews were conducted separately for 28 adolescents with asthma aged 12-18 years, 14 healthcare professionals, and 12 parents. Focus groups and interviews were audio-recorded and transcripts from each participant group were analysed separately using inductive thematic analysis. We triangulated the three perspectives by comparing themes that had emerged from each analysis. RESULTS: Adolescents', parents', and healthcare professionals' views were summarised into ten related themes that included forgetting and routines, knowledge, embarrassment and confidence, communication with healthcare professionals, triggers, support at school, apathy, and taking responsibility. We found that adolescents, parents and healthcare professionals raised similar barriers and facilitators to self-management and our results provide further validation for previous studies. CONCLUSION AND CLINICAL RELEVANCE: Our study highlights that healthcare professionals may need to consider a range of psychological and contextual issues influencing adolescents' ability to effectively self-manage their asthma, in particular, how they implement treatment routines and the understanding that adolescents have of their condition and treatments. Crucially, healthcare professionals need to consider how this information is communicated and ensure they facilitate open, inclusive, two-way consultations. From this more comprehensive understanding, we have developed interventional strategies that healthcare professionals can utilise to empower adolescents to improve their asthma self-management. This article is protected by copyright. All rights reserved
Understanding Galaxy Formation and Evolution
The old dream of integrating into one the study of micro and macrocosmos is
now a reality. Cosmology, astrophysics, and particle physics intersect in a
scenario (but still not a theory) of cosmic structure formation and evolution
called Lambda Cold Dark Matter (LCDM) model. This scenario emerged mainly to
explain the origin of galaxies. In these lecture notes, I first present a
review of the main galaxy properties, highlighting the questions that any
theory of galaxy formation should explain. Then, the cosmological framework and
the main aspects of primordial perturbation generation and evolution are
pedagogically detached. Next, I focus on the ``dark side'' of galaxy formation,
presenting a review on LCDM halo assembling and properties, and on the main
candidates for non-baryonic dark matter. It is shown how the nature of
elemental particles can influence on the features of galaxies and their
systems. Finally, the complex processes of baryon dissipation inside the
non-linearly evolving CDM halos, formation of disks and spheroids, and
transformation of gas into stars are briefly described, remarking on the
possibility of a few driving factors and parameters able to explain the main
body of galaxy properties. A summary and a discussion of some of the issues and
open problems of the LCDM paradigm are given in the final part of these notes.Comment: 50 pages, 10 low-resolution figures (for normal-resolution, DOWNLOAD
THE PAPER (PDF, 1.9 Mb) FROM http://www.astroscu.unam.mx/~avila/avila.pdf).
Lectures given at the IV Mexican School of Astrophysics, July 18-25, 2005
(submitted to the Editors on March 15, 2006
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients
The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation
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