New Findings in the Netherlands about Induced Demand and the Benefits of New Road Infrastructure

AbstractThe increase in traffic volume that arises after opening of new road infrastructure, is often attributed to ‘induced demand’. The objective of this study is to provide empirically derived insights in this phenomenon, in the amount of induced demand and in the benefits that adding road infrastructure has for users. Based on multivariate analyses of detailed data in The Netherlands from 2000-2012, it is concluded that the amount of induced demand in total is relatively low and that the relatively large increase in traffic volume during peak hours on roads that were congested before adding lanes mainly has been caused by shifts in route and departure time. The benefits of the new infrastructure for users have been calculated in terms of savings of travel time and travel time reliability. Implications for cost-benefit analyses of road investments have been reviewed

Improved science-based transformation pathways for the development of safe and sustainable plastics

Environmental Biolog

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants

Familial hematuria

Hematuria is a common presenting complaint in pediatric nephrology clinics and often has a familial basis. This teaching article provides an overview of causes, diagnosis, and management of the major forms of familial hematuria, Alport syndrome, and thin basement membrane nephropathy

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

Contrary to prior models in which titin serves as a stable scaffold in sarcomeres, sarcomeric and soluble titin exchange dynamically in myofibers when calcium levels are low