Brexit: Over & out?

Op 23 juni 2016 heeft het Britse volk zich in een raadgevend referendum uitgesproken voor een vertrek van het Verenigd Koninkrijk uit de Europese Unie. De overwinning van het Leave kamp zorgt voor een ongekende primeur: sinds zijn ontstaansgeschiedenis heeft EU immers enkel uitbreidingen gekend, tot zijn huidige omvang met 28 lidstaten en circa 500 miljoen EU burgers. De nakende Brexit brengt heel wat onrust en onzekerheid met zich mee, voor burgers, bedrijven en staten. Deze bijdrage gaat nader in op het proces van uittreding en bespreekt de opties en uitdagingen voor de nieuw te onderhandelen relatie tussen het Verenigd Koninkrijk en de EU. Afgesloten wordt met een korte reflectie op de mogelijke gevolgen van een Brexit voor de EU en Nederland The progression of EU law: Accommodating change and upholding value

Het dienstenverkeer tussen de EU en het Verenigd Koninkrijk na Brexit

The progression of EU law: Accommodating change and upholding value

Quality of herbage at different latitudes.

In a cooperative experiment, yield and herbage quality of timothy was measured during the uninterrupted growth of the 1st cut at 6 lat. (51-69 deg N). Rate of production was greatest at Tromso (69 deg N), apparently because of the long day and rapid reproductive development. Digestibility of OM declined faster at higher lat. because stem development proceeded faster and less leaf DM was produced. At the same morphological stage, digestibility of the whole crop was better at higher lat. because of the better digestibility of the cell walls from the stems. It was concluded that rate of lignification could not keep pace with the rapid rate of stem development. (Abstract retrieved from CAB Abstracts by CABI’s permission

Microbial sophorolipids inhibit colorectal tumour cell growth in vitro and restore haematocrit in Apcmin+/− mice

Sophorolipids are glycolipid biosurfactants consisting of a carbohydrate sophorose head with a fatty acid tail and exist in either an acidic or lactonic form. Sophorolipids are gaining interest as potential cancer chemotherapeutics due to their inhibitory effects on a range of tumour cell lines. Currently, most anti-cancer studies reporting the effects of sophorolipids have focused on lactonic preparations with the effects of acidic sophorolipids yet to be elucidated. We produced a 94% pure acidic sophorolipid preparation which proved to be non-toxic to normal human colonic and lung cells. In contrast, we observed a dose-dependent reduction in viability of colorectal cancer lines treated with the same preparation. Acidic sophorolipids induced apoptosis and necrosis, reduced migration, and inhibited colony formation in all cancer cell lines tested. Furthermore, oral administration of 50 mg kg(-1) acidic sophorolipids over 70 days to Apc(min+/-) mice was well tolerated and resulted in an increased haematocrit, as well as reducing splenic size and red pulp area. Oral feeding did not affect tumour numbers or sizes in this model. This is the first study to show that acidic sophorolipids dose-dependently and specifically reduces colon cancer cell viability in addition to reducing tumour-associated bleeding in the Apc(min+/-) mouse model

WS1.3 Respiratory microbiota dynamics in newborns with cystic fibrosis and healthy controls: A longitudinal study

IEEEMost malware are introduced into a computer system by applications that communicate with the outside world. These applications (called portals) are key components for system security. This paper presents an efficient anti-malware framework un