Higgs boson as a gluon trigger: the study of QCD in high pile-up environments

In the forthcoming high-luminosity phase of the LHC many of the most interesting measurements for precision QCD studies are hampered by large pile-up conditions, especially at not very high transverse momenta. However, with the recently discovered Higgs boson, which couples in the heavy top limit directly to gluons, we have access to a novel production process to probe QCD by a colour-singlet current. In this study we compare observables in Higgs boson and Drell-Yan production and investigate whether measuring ratios or subtractions can yield results that are stable in high pile-up environments, and yet sensitive to (small-$p_{\text{T}}$) QCD physics in gluon fusion processes. We present results of Monte Carlo event generator calculations for a few specific examples.Comment: 7 pages, 10 figures, DIS2014 conference proceeding

Towards Independent Particle Reconstruction from Cryogenic Transmission Electron Microscopy

Coronary heart disease is the single largest killer of Americans so improved means of detecting risk factors before arterial obstructions appear are expected to lead to a improvement in quality of life with a reduced cost. This paper introduces a new approach to 3-D reconstruction of individual particles based on statistical modeling from a sparse set of 2-D projection images. This paper introduces a new approach to 3-D reconstruction of individual particles based on statistical modeling from a sparse set of 2-D projection images. The method is in contrast to the current state of practice where reconstruction is performed via signal processing or Bayesian methods that use averaged images acquired from an ensemble of particles. As such, this new approach has its impetus in use for novel diagnostic tests such as LDL and HDL particle shape characterization. The approach is also expected to have uses in areas such as quality assurance for drug delivery nano-technologies and for general proteomic studies. The individual particle reconstruction algorithm is based on a hidden Markov model. Higher order Markov chain statistics, which are generated from the a priori model of the target of interest, can be derived from traditional methods such as single particle reconstruction and/or the underlying physical properties of the particle. By placing the reconstruction voxel space at a 45° angle to the projection image, 4-passes of the HMM processing can be performed from a single image. Reconstruction results from a simple model and a single projection image resulted in better than 98% reconstruction accuracy as compared to the original target

Elaboration of a quantification assay of marinobufagenin in human plasma: a novel approach based on response factor quantification by LC-MS/MS

Marinobufagenin (MBG) is a bufadienolide cardiac inotrope implicated in the early diagnosis of volume expansion-mediated hypertensive states such as preeclampsia (PE). Endogenous MBG is an inhibitor of the α1 isoform of Na+,K+-ATPase with vasoconstrictive and cardiotonic properties,resulting in hypertension and natriuresis. Elevated endogenous MBG levels have been described in pregnant mammals and especially in preeclamptic patients [1-3]. The rise of endogenous MBG seems to appear prior the development of the main symptoms of PE, leading us to consider MBG as one of the potential biomarkers for PE. This demonstrates the need for a sensitive analytical method to detect MBG in plasma at low levels. Currently, the enhanced production of MBG in preeclamptic patients has been described using poor-specific immunoassays based on the detection of marinobufagenin-like material [4,5]. These techniques suffer from a lack of specificity due to cross-reactivity and tend to exhibit high variability at low concentrations [6]. Moreover, the two studies that recorded MBG plasma levels in preeclampsia compared to normal pregnancy are in marked discrepancy concerning the values of MBG plasma concentration. Our aim is to develop a specific and sensitive analytical MBG assay by LC-MS/MS with special attention to the limit of quantification (LOQ). An algorithm dealing with the MBG plasma levels might be established in the future, in order to help for prediction of the risk for preeclampsia in pregnant women. As the major source for MBG is located in the parotid glands of the Bufo marinus toad, we developed a purification method from toad venom in order to get pure MBG standard. The identity of the compound was confirmed using TLC-MS and HPLC-MS/MS. A very sensitive and specific LC-MS/MS based assay is now being optimized in order to determine MBG in human plasma. The assay is preceded by an extraction step of the plasma on SLE cartridges. Using 5α-dihydrotestosterone-d3 as internal standard for response factor calculation, the obtained LOQ fully satisfies the need for quantification of MBG plasma levels in pregnancy (nmol/L range). This assay allowed us to confirm the identity of MBG in a woman plasma, before and during pregnancy

Effects of hyperoxia and cardiovascular risk factors on myocardial ischemia reperfusion injury: a randomized, sham and placebo controlled parallel study

peer reviewedRecent studies on O2 supplementation in acute coronary syndrome patients are equivocal. We tested the hypothesis that oxidative stress (OS) is increased in rodents with cardiovascular risk factors and enhances ischemia reperfusion injury in the presence of hyperoxia. Forty-three Wistar rats (WR), 30 spontaneous hypertensive rats (SHR) and 33 obese Zucker rats (ZR) were randomized in a sham procedure (1/3rd) or a left anterior descending ligation for 60 minutes (2/3rd). This was followed by 3 hours of reperfusion while animals were randomised either in a hyperoxic (HR) or a normoxic reperfusion group (NR). Baseline troponin (cTnT) was larger in SHR and ZR than WR (both p < 0.001). HR was associated with a lesser troponin rise in SHR and ZR than in NR (both p < 0.001); while the reverse occurred in WR (p < 0.001). In SHR, HR limited total MPO (myeloperoxydase) increase as compared to NR (p = 0.0056) to the contrary of total MPO in WR (p = 0.013). NR was associated with a drastic reduction of total thiols as compared to HR both in SHR and in ZR (both p < 0.001). Despite a heightened baseline OS, HR rather restrained myocardial necrosis and anti/pro-oxidant imbalance in SHR and ZR, to the reverse of healthy WR

Discrete element modelling of the packing of spheres and its application to the structure of porous metals made by infiltration of packed beds of NaCl beads

A numerical model, using the discrete element method, has been developed to quantify specific parameters that are pertinent to the packing behaviour of relatively large, spherical NaCl beads and mixtures of beads of different sizes. These parameters have been compared with porosity and connectivity measurements made on porous aluminium castings made by molten metal infiltration into packed beds of such beads, after removal of the NaCl by dissolution. DEM has been found to accurately predict the packing fraction for salt beads with both mono and binary size distributions and from this the pore fractions in castings made by infiltration into packed beds of beads could be predicted. Through simple development of the condition for contacting of neighbouring beads, the number of windows linking neighbouring pores, and their size, could also be predicted across a wide range of small bead additions. The model also enables an insight into the mixing quality and changes in connectivity introduced through the addition of small beads. This work presents significant progress towards the delivery of a simulation based approach to designing preform architectures in order to tailor the resulting porous structures to best suit specific applications

Mastication Dyspraxia: A Neurodevelopmental Disorder Reflecting Disruption of the Cerebellocerebral Network Involved in Planned Actions

This paper reports the longitudinal clinical, neurocognitive, and neuroradiological findings in an adolescent patient with nonprogressive motor and cognitive disturbances consistent with a diagnosis of developmental coordination disorder (DCD). In addition to prototypical DCD, the development of mastication was severely impaired, while no evidence of swallowing apraxia, dysphagia, sensorimotor disturbances, abnormal tone, or impaired general cognition was found. He suffered from bronchopulmonary dysplasia and was ventilated as a newborn for 1.5 months. At the age of 3 months, a ventriculoperitoneal shunt was surgically installed because of obstructive hydrocephalus secondary to perinatal intraventricular bleeding. At the age of 5 years, the patient’s attempts to masticate were characterized by rough, effortful, and laborious biting movements confined to the vertical plane. Solid food particles had a tendency to get struck in his mouth and there was constant spillage. As a substitute for mastication, he moved the unground food with his fingers in a lateral direction to the mandibular and maxillary vestibule to externally manipulate and squeeze the food between cheek and teeth with the palm of his hand. Once the food was sufficiently soft, the bolus was correctly transported by the tongue in posterior direction and normal deglutition took place. Repeat magnetic resonance imaging (MRI) during follow-up disclosed mild structural abnormalities as the sequelae of the perinatal intraventricular bleeding, but this could not explain impaired mastication behavior. Quantified Tc-99m-ethylcysteinate dimer single-photon emission computed tomography (Tc-99m-ECD SPECT), however, revealed decreased perfusion in the left cerebellar hemisphere, as well as in both inferior lateral frontal regions, both motor cortices, and the right anterior and lateral temporal areas. Anatomoclinical findings in this patient with DCD not only indicate that the functional integrity of the cerebellocerebral network is crucially important in the planning and execution of skilled actions, but also seem to show for the first time that mastication deficits may be of true apraxic origin. As a result, it is hypothesized that “mastication dyspraxia” may have to be considered as a distinct nosological entity within the group of the developmental dyspraxias following a disruption of the cerebellocerebral network involved in planned actions

Temporal Dissociation between Myeloperoxidase (MPO)-Modified LDL and MPO Elevations during Chronic Sleep Restriction and Recovery in Healthy Young Men

OBJECTIVES: Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers. METHODS AND RESULTS: Nine healthy male non-smokers, aged 22-29 years, were admitted to the Sleep Laboratory for 11 days and nights under continuous electroencephalogram polysomnography. The study consisted of three baseline nights of 8 hours sleep (from 11 pm to 7 am), five sleep-restricted nights, during which sleep was allowed only between 1 am and 6 am, and three recovery nights of 8 hours sleep (11 pm to 7 am). Myeloperoxidase-modified low-density lipoprotein levels increased during the sleep-restricted period indicating an oxidative stress. A significant increase in the quantity of slow-wave sleep was measured during the first recovery night. After this first recovery night, insulin-like growth factor-1 levels increased and myeloperoxidase concentration peaked. CONCLUSIONS: We observed for the first time that sleep restriction and the recovery process are associated with differential changes in blood biomarkers of cardiovascular disease

Solution of the Bethe-Salpeter equation for pion-nucleon scattering

A relativistic description of pion-nucleon scattering based on the four-dimensional Bethe-Salpeter equation is presented. The kernel of the equation consists of s- and u-channel nucleon and delta pole diagrams, as well as rho and sigma exchange in the t-channel. The Bethe-Salpeter equation is solved by means of a Wick rotation, and good fits are obtained to the s- and p-wave phase shifts up to 360 MeV pion laboratory energy. The coupling constants determined by the fits are consistent with the commonly accepted values in the literature.Comment: 34 pages, RevTeX; 7 figures. Several references added, a few typos corrected. Accepted for publication in Physical Review

Meson-exchange Model for πN\pi N scattering and γN−>πN\gamma N -> \pi N reaction

An effective Hamiltonian consisting of bare $\Delta \leftrightarrow\pi N$, $\gamma N$ vertex interactions and energy-independent meson-exchange $\pi N \leftrightarrow \pi N, \gamma N$ transition operators is derived by applying a unitary transformation to a model Lagrangian with $N,\Delta,\pi$, $\rho$, $\omega$, and $\gamma$ fields. With appropraite phenomenological form factors and coupling constants for $\rho$ and $\Delta$, the model can give a good description of $\pi N$ scattering phase shifts up to the $\Delta$ excitation energy region. It is shown that the best reproduction of the recent LEGS data of the photon-asymmetry ratios in $\gamma p \rightarrow \pi ^0 p$ reactions provides rather restricted constraints on the coupling strengths $G_E$ of the electric $E2$ and $G_M$ of the magnetic $M1$ transitions of the bare $\Delta \leftrightarrow \gamma N$ vertex and the less well-determined coupling constant $g_{\omega NN}$ of $\omega$ meson. Within the ranges that $G_M = 1.9 \pm 0.05$, $G_E = 0.0 \pm 0.025$, and $7 \leq g_{\omega NN}\leq 10.5$, the predicted differential cross sections and photon-asymmetry ratios are in an overall good agreement with the data of $\gamma p \rightarrow \pi ^0 p$, $\gamma p \rightarrow \pi ^+ n$, and $\gamma n\rightarrow \pi ^- p$ reactions from 180 MeV to the $\Delta$ excitation region. The predicted $M_{1^+}$ and $E_{1^+}$ multipole amplitudes are also in good agreement with the empirical values determined by the amplitude analyses. The constructed effective Hamiltonian is free of the nucleon renormlization problem and hence is suitable for nuclear many-body calculations. We have also shown that the assumptions made in the $K$-matrix method, commonly used in extracting empirically the $\gamma N \rightarrow \Delta$ transition amplitudes from the data, are consistent withComment: 49 pages + 23 Figures, Revte