The Impact of Brand Value Towards Stock Price in Indonesian Banking Industry

Brand value is especially important in banking industry, because it enables firms to get recognition from customers as well as gaining loyalty, which is pivotal in determining firms\u27 success. The purpose of this research is to determine whether brand value affects company performance in the form of stock price. The research is conducted over four biggest banks in Indonesia in terms of market capitalization in Indonesian, namely Bank BCA, Bank Mandiri, Bank Danamon, and Bank BRI, which are observed over eight years of operation (2007-2014). Multiple linear regression method was used in this research, with the stock price as dependent variable and brand value, along with three financial performance indicators as the independent variable. The results of the research indicate that in Indonesian Banking Industry, brand value does not significantly affect stock price, at least individually. Instead, Earnings per Share is found to be the only significant impacting variable towards stock price

Investigation of D7S496 marker characteristics in five Iranian ethnic groups for linkage analysis of autosomal recessive non syndromic hearing loss

Background and aims: The most important currently identifiable genetic cause of autosomal recessive non syndromic hearing loss (ARNSHL) after GJB2 mutations are the SLC26A4 gene mutations. In this investigation, the characteristics and informativeness of D7S496 CA repeat STR marker in SLC26A4 gene region was examined in five ethnic groups of the Iranian population. Methods: The locus were genotyped in 165 individuals of five different ethnic groups including Fars, Azari, Turkmen, Gilaki and Arabs using PCR followed by PAGE and fluorescent capillary electrophoresis. In this study, the results were analyzed by GeneMarker HID Human STR Identity software, GenePop program and Microsatellite Tools software. Results: Analysis of the allelic frequency revealed the presence of 10 alleles for D7S496 marker in the Iranian population, which allele 137bp at the D7S496 locus with 41.52% allele frequency was the most frequent. The observed heterozygosity of all ethnic groups was approximately above 70%, which Turkmen ethnic had the highest heterozygosity among all. Finally, analysis of PIC value represents D7S496 marker as a highly informative marker in Iranian population (PIC value above 0.7). Conclusion: Our data introduce D7S496 as a highly informative marker in diagnosis of SLC26A4 based ARNSHL by Linkage analysis

Analisa Pengendalian Bahan Baku Pada Depot Mie Dan Lemper 168 Di Surabaya

Karya tulis ini bertujuan untuk membandingkan perhitungan manajemenbahan baku metode konvensional dengan metode EOQ pada Depot Mie dan Lemper 168. Hal yang melatar belakangi penelitian ini adalah masalah manajemen bahan baku yang dihadapi pemilik USAha. Variabel perhitungan yang ingin dihitung adalah EOQ, reorder point, safety stock, forecast, total cost, dan order frequency. Hasil penelitian menunjukkan bahwa perhitungan dengan metode EOQ menghasilkan perhitungan yang lebih efektif daripada perhitungan tanpa metode. The purpose of this research is to compare store management calculation using conventional method against EOQ method in Depot Mie dan Lemper 168. The reason we choose this topic is because Depot Mie dan Lemper 168 faces problem with their store management. Our variable calculations are EOQ, reorder point, safety stock, forecast, total cost and order frequency. The result shows that calculation using EOQ method produce smaller numbers which indicates effectiveness

Pengaruh Efikasi Diri ( Self Efficacy) dan pengembangan karir terhadap kepuasan kerja karyawan pada PT. Bangun Bina Persada, Kabupaten Bandung

Kepuasan kerja merupakan sikap umum seorang individu terhadap pekerjaannya, seorang dengan tingkat kepuasan kerja tinggi menunjukkan sikap yang positif terhadap pekerjaan itu, seorang yang tidak puas dengan pekerjaannya. Faktor yang berpengaruh terhadap kepuasan kerja adalah pengembangan karir. Dengan adanya pengembangan karir yang baik maka karyawan akan merasa termotivasi sehingga menciptakan rasa puas dalam melaksanakan pekerjaan. Populasi dalam penelitian ini adalah semua karyawan PT. Bagun Bina Persada, Kabuptaten Bandung. Sampel yang digunakan sebanyak 78 responden dengan teknik Sampling. Teknik pengumpulan data dengan kuesioner, sedangkan teknik analisis data menggunakan analisis regresi linier berganda, uji hipotesis, uji statistik (uji t, uji F dan koefisien determinasi). Berdasarkan hasil analisis regresi linier berganda dari uji t diperoleh temuan bahwa secara parsial efikasi dir berpengaruh signifikan terhadap kepuasan kerja dan pengembangan karir berpengaruh signifikan. Dari hasil uji F bahwa secara simultan koefisien determinasi dapat dilihat pada R-Square yaitu sebesar 0,438 atau 43,8%, artinya secara simultan efikasi diri (self-efficacy) (X1) dan pengembangan karir (X2) memberikan pengaruh sebesar 43,8% terhadap kepuasan kerja (Y). Sedangkan sisanya sebesar 56,2% dipengaruhi oleh faktor lain yang tidak diteliti di dalam penelitian ini, yaitu merupakan pengaruh variabel lain diluar ke dua variabel efikasi dir dan pengembangan karir

Analysis of polymorphic marker rs9384 located in the GCDH gene region associated with glutaricaciduria type 1.

زمینه و هدف: گلوتاریک اسید یوریای نوع 1 نوعی اختلال متابولیکی عصبی می باشد که در اثر جهش در ژن رمز کننده آنزیم گلوتاریل کوآدهیدروژناز (GCDH) ایجاد می شود. اصولاً تعیین توالی به منظور شناسایی جهش ‌های نقطه ای و دیگر تنوعات توالی موجود در این ژن استفاده می‌شود که بسیار وقت ‌گیر و پر هزینه می ‌باشد. روش دیگر بررسی پیوستگی با استفاده از مارکرهای چند شکلی مانند چند شکلی های تک نوکلئوتیدی (SNP) است که برای تعیین افراد ناقل و همچنین تشخیص پیش از تولد در خانواده‌های دارای فرد مبتلا به کار می ‌رود. در پایگاه‌ های داده تعداد زیادی از مارکرهای SNP برای ناحیه ژنی GCDH معرفی شده است. در مطالعه حاضر خصوصیات و همچنین اطلاع دهندگی مارکر rs9384 واقع در ناحیه ژنی GCDH مورد بررسی قرار گرفت. روش بررسی: مارکر rs9384 در 100 فرد سالم غیر خویشاوند با روش ARMS PCR با بهره گیری از پرایمرهای جدید طراحی شده تعیین ژنوتیپ شد. در این مطالعه تخمین فراوانی آللی و درجه هتروزیگوسیتی با استفاده از پایگاه GenePop انجام شد؛ همچنین از نرم ‌افزار Power Marker برای تخمین وجود تعادل هاردی واینبرگ و میزان محتوی اطلاع دهندگی چند شکلی (PIC) استفاده شد. یافته ها: نتایج حاصل از این مطالعه بیانگر فراوانی آللی مینور (MAF) 0/34، درجه هتروزیگوسیتی 0/53 و مقدار 0/35=PIC برای مارکر rs9384 در جمعیت مورد مطالعه بود. به علاوه بررسی تعادل هاردی واینبرگ نشان داد که جمعیت برای این مارکر در تعادل می‌ باشد. نتیجه گیری: در مجموع با توجه به نتایج به دست آمده از مطالعه حاضر می‌ توان مارکر rs9384 را به عنوان یک مارکر تک نوکلئوتیدی مناسب جهت تشخیص مولکولی گلوتاریک اسید یوریای نوع 1 در جمعیت اصفهان به عنوان نمونه‌ ای از جمعیت ایرانی معرفی کرد

REFORMULASI PENETRATION STRESS TEST SEBAGAI PERLINDUNGAN HUKUM DATA PRIBADI KONSUMEN DI ERA BISNIS DIGITAL

This research focus on consumer personal data protection as a part of invention from privacy right in digital era. The high number of consumer personal data utilization by electronic system operator not accompanied with decent penetration stress test (PST) regulation. The purpose of this research is to give solution to clear personal data protection problem through PST testing method. The method that used by this research is normative research through statutory approach and conceptual approach. The result from this research concludes that there are still many problematic PST regulation. The problem can be seen from personal data protection that shattered in 30 statutory from different sector with no one arrange PST comprehensively. This dispute culminates to emergence dissimilarity definition, overlapping authority between receiver of System Management Security Information certification annual report, and PST operator polemic. As the result, it causes rampant of personal data breach that inflict consumer by matter, along with specific data exploitation that lead to sluggish business and economic country. Therefore, PST testing reformulation is needed as prevention step to protect consumer personal data in digital business era

Genotyping Data and Novel Haplotype Diversity of STR Markers in the SLC26A4 Gene Region in Five Ethnic Groups of the Iranian Population

Background and Aims: SLC26A4 gene mutations are the second currently identifiable genetic cause of autosomal recessive nonsyndromic hearing loss after GJB2 mutations. Because of the extensive size of the SLC26A4 gene and the variety of mutations, indirect diagnosis using linkage analysis has been suggested. Therefore, in this investigation three potential short tandem repeat (STR) markers related to this region including D7S2420, D7S496, and D7S2459 were selected for further analysis. Methods: The characteristics and haplotype frequency of the markers were examined for the first time in five ethnic groups of the Iranian population including Fars, Azari, Turkmen, Gilaki, and Arab using the polymerase chain reaction followed by fluorescent capillary electrophoresis. Results were analyzed by GeneMarker HID Human STR Identity, GenePop, Microsatellite tools, PowerMarker 3.25, and Arlequin 3.5 software. Results: Analysis of the allelic frequency revealed the presence of 11, 10, and 8 alleles for D7S2420, D7S496, and D7S2459 markers, respectively, in the Iranian population. The detailed analysis of each ethnic group was reported. Calculated polymorphism information content values were above 0.7 in the Iranian population. Pairwise linkage disequilibrium (LD) revealed a significant LD in pairing markers of D7S2420-D7S496 and in D7S496-D7S2459. Estimation of the haplotype frequency showed the presence of 20, 13, 15, 15, and 20 informative haplotypes in Fars, Azari, Turkmen, Gilaki, and Arabian ethnics, respectively. Conclusion: Together, the investigated markers could be suggested as powerful tools for linkage analysis of SLC26A4 gene mutations in the Iranian population

UGT1A1 gene linkage analysis: application of polymorphic markers rs4148326/rs4124874 in the Iranian population

Objective(s): Mutations in the UGT1A1 gene are responsible for hyperbilirubinemia syndromes including Crigler-Najjar type 1 and 2 and Gilbert syndrome. In view of the genetic heterogeneity and involvement of large numbers of the disease causing mutations, the application of polymorphic markers in the UGTA1 gene could be useful in molecular diagnosis of the disease. Materials and Methods: In the present study, two polymorphic markers including rs4148326 and rs4124874 in the UGT1A1 gene region were characterized. The markers were selected using bioinformatics analysis of the UGT1A1 gene region and genotyped in 212 unrelated healthy individuals and 13 family trios in the Iranian population using Tetra-Primer ARMS PCR technique. The allele frequency and population status of the alleles were estimated using GENEPOP, FBAT, PowerMarker and Arlequin software. Results: The results indicated that in the case of rs4148326 marker, allele frequency for T and C allele was 66.04% and 33.96%, respectively. For rs4124874 marker, allele frequency for G and T alleles was 39.4% and 60.6%, respectively. The values of heterozygosity index for the markers examined were 64.1 for rs4148326 and 72.1 for rs4124874, respectively. The haplotype estimation analysis of the markers resulted in three informative haplotypes with frequencies ≥0.05. Moreover, the results suggested the presence of linkage disequilibrium between two markers. Conclusion: Altogether, the data suggested that rs4148326 and rs4124874 could be introduced as informative markers for molecular diagnosis of Crigler-Najjar type 1 and 2 and Gilbert syndrome in the Iranian population

Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor

Gene amplification and enhanced expression of the epidermal growth factor receptor (EGFR) represent the major molecular genetic alteration in glioblastomas and it may play an essential role in cell growth and in the carcinogenic process. On the other hand, the nuclear suppressor proteins PML and p53 are also known to play critical roles in cancer development and in suppressing cell growth. Here we report that, in glioblastoma cells with defective EGFR function, the expressions of both promyelocytic leukaemia (PML) and p53 were altered. Cells that were transfected with the antisense-cDNA of EGFR were found to have more cells in G1 and fewer cells in S phase. In addition, the transfected cells were found to be non-responsive to EGF-induced cell growth. Interestingly, the expression of the suppressors p53 and PML were found to be significantly increased by immunohistochemical assay in the antisense-EGFR cells. Moreover, the PML expression in many of the cells was converted from the nuclear dot pattern into fine-granulated staining pattern. In contrast, the expressions of other cell cycle regulated genes and proto-oncogene, including the cyclin-dependent kinase 4 (cdk4), retinoblastoma, p16INK4a and p21H-ras, were not altered. These data indicate that there are specific inductions of PML and p53 proteins which may account for the increase in G1 and growth arrest in antisense-EGFR treated cells. It also indicates that the EGF, p53 and PML transduction pathways were linked and they may constitute an integral part of an altered growth regulatory programme. The interactions and cross-talks of these critical molecules may be very important in regulating cell growth, differentiation and cellular response to treatment in glioblastomas. © 1999 Cancer Research Campaig