The Meaning of Rye

Positive scientific literature on the agronomical characteristics of rye and the health implications of ingesting rye abounds. To better understand why people choose to engage with certain crops and not others, scientific facts do not always suffice. It is helpful to have some insights into the practical knowledge that people possess and that might guide their action. Rye as a food crop necessitates the coming together of people with different skillsets and tools to make it from the seed depositories to people’s tables. Positioned at the intersection of agriculture and anthropology, this dissertation investigates the meaning of rye for the different actors who have chosen to engage with it. In-depth interviews with breeders, farmers, millers, bakers, eaters and learners as well as numerous farm, mill and bakery visits in the U.S., UK and Estonia combined with digital ethnography and field and baking trials inform the discussion. This dissertation attends to people’s rye-related ideas and opinions and looks at how that knowledge informs and is informed by action. The emphasis is on the contextualization of knowledge and the interconnectedness of different actors through rye, whilst being attentive to the fluid materiality of rye. Drawing on multi-species ethnography theories, the concept of assemblage is applied in explaining how the meaning of rye comes into being through the joint yet separate action of individuals. These observations about the motivations of different actors could be valuable in contemplating the possibility of change in our food system and moving the focus away from the global to the local where the connections between the different actors are both more accessible and more meaningful. It is the very marginality of rye in the U.S. food system that makes it a suitable conceptual as well as a practical tool for reconsidering priorities in food production and envisioning a different way of growing, processing and utilizing grains that is focused on relationality and connectedness

Nematic spectral signatures of the Hund's metal

We show, by means of dynamical mean-field theory calculations, that the experimental fingerprints of thenematic order in iron-based superconductors are intrinsically connected with the electronic correlations inthe Hund's correlated metallic state and they cannot be accessed via a renormalized quasiparticle picture. Inparticular, our results show that (i) in a metal in which correlations are dominated by the Hund's coupling thenematic ordering does not produce a rigid energy shift in the photoemission spectra, but a much richer spectralweight redistribution which mirrors the experimental results, and (ii) the nematic ordering is characterized by anorbital-selective coherence induced by the Hund's physics in agreement with the experimental pictur

AIKA TIKITTÄÄ JOHTAJALLE, VOIKO KIIREESSÄ KEHITTYÄ? – Johtajuuden tiimalasi syväjohtamisen jatkomallina

Leadership is challenging and time-consuming. It takes more than a leader and a follower. In this article, the concept of the transformational leadership has been approached with a qualitative, abductive view. The article is based on the author’s Master’s thesis study for the Department of Management Studies at the University of Tampere. The Finnish Defence Forces has used the model of deep leadership, based on the transformational leadership, for a decade with controversial results. The main focus is on exploring the ways the instructors, who train conscripts, use the deep leadership model when they are evolving their own leadership skills. The results of the qualitative study suggest that the instructors need more support and guidance than they feel they are receiving from their superiors. Tight schedules, spatial factors and the shortage of resources available cause lack of motivation, when it comes to improving as a leader. The study’s conclusions can be presented in the hourglass model of leadership. This on the other hand brings up the questions of are The Finnish Defence Forces implementing an unsuitable leadership model or should the idea of leadership be reconsidered instead. Critical approach should be considered as one possible tool for renewing the deep leadership model

Endolymphatic potassium of the chicken vestibule during embryonic development

The endolymph fills the lumen of the inner ear membranous labyrinth. Its ionic composition is unique in vertebrates as an extracellular fluid for its high-K(+)/low-Na(+) concentration. The endolymph is actively secreted by specialized cells located in the vestibular and cochlear epithelia. We have investigated the early phases of endolymph secretion by measuring the endolymphatic K(+) concentration in the chicken vestibular system during pre-hatching development. Measurements were done by inserting K(+)-selective microelectrodes in chicken embryo ampullae dissected at different developmental stages from embryonic day 9 up to embryonic day 21 (day of hatching). We found that the K(+) concentration is low (<10mM/L) up to embryonic day 11, afterward it increases steeply to reach a plateau level of about 140 mM/L at embryonic day 19--21. We have developed a short-term in vitro model of endolymph secretion by culturing vestibular ampullae dissected from embryonic day 11 chicken embryos for a few days. The preparation reproduced a double compartment system where the luminal K(+) concentration increased along with the days of culturing. This model could be important for (1) investigating the development of cellular mechanisms contributing to endolymph homeostasis and (2) testing compounds that influence those mechanisms

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

<p>Abstract</p> <p>Background</p> <p>Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been elucidated yet. Recent works on amphibians showed that histamine H3 receptor antagonists, e.g. betahistine, inhibit the afferent discharge recorded from the vestibular nerve. To assess the expression of H3 histamine receptors in vestibular neurons, we performed mRNA RT-PCR and immunofluorescence experiments in mouse Scarpa's ganglia.</p> <p>Results</p> <p>RT-PCR analysis showed the presence of H3 receptor mRNA in mouse ganglia tissue. H3 protein expression was found in vestibular neurons characterized by large and roundish soma, which labeled for calretinin and calbindin.</p> <p>Conclusion</p> <p>The present results are consistent with calyx and dimorphic, but not bouton, afferent vestibular neurons expressing H3 receptors. This study provides a molecular substrate for the effects of histamine-related antivertigo drugs acting on (or binding to) H3 receptors, and suggest a potential target for the treatment of vestibular disorders of peripheral origin.</p

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis

We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial. Herein, we show the modulatory action of thyroid status on the in vivo growth of T lymphoma cells. For this purpose, euthyroid, hypothyroid, and hyperthyroid mice received inoculations of EL4 cells to allow the development of solid tumors. Tumors in the hyperthyroid animals exhibited a higher growth rate, as evidenced by the early appearance of palpable solid tumors and the increased tumor volume. These results are consistent with the rate of cell division determined by staining tumor cells with carboxyfluorescein succinimidyl ester. Additionally, hyperthyroid mice exhibited reduced survival. Hypothyroid mice did not differ significantly from the euthyroid controls with respect to these parameters. Additionally, only tumors from hyperthyroid animals had increased expression levels of proliferating cell nuclear antigen and active caspase 3. Differential expression of cell cycle regulatory proteins was also observed. The levels of cyclins D1 and D3 were augmented in the tumors of the hyperthyroid animals, whereas the cell cycle inhibitors p16/INK4A (CDKN2A) and p27/Kip1 (CDKN1B) and the tumor suppressor p53 (TRP53) were increased in hypothyroid mice. Intratumoral and peritumoral vasculogenesis was increased only in hyperthyroid mice. Therefore, we propose that the thyroid status modulates the in vivo growth of EL4 T lymphoma through the regulation of cyclin, cyclin-dependent kinase inhibitor, and tumor suppressor gene expression, as well as the stimulation of angiogenesis.Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina ; ArgentinaFil: Valli, Eduardo. Pontificia Universidad Católica Argentina ; ArgentinaFil: Cayrol, Maria Florencia. Pontificia Universidad Católica Argentina ; ArgentinaFil: Paulazo, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Díaz Flaqué, María Celeste. Pontificia Universidad Católica Argentina ; ArgentinaFil: Klecha, Alicia Juana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Colombo, L.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; ArgentinaFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cremaschi, Graciela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentin

Clinical Effects of an ACT-Group Training in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

Abstract Objective The aim of the present study is evaluate the effectiveness of an Acceptance and Commitment Therapy (ACT)-based training protocol, in adjunct to token economy and previous parent training, in a sample of children with Attention-Deficit/Hyperactivity Disorder (ADHD). By promoting the reduction of immediate responses to thoughts and feelings, we aimed to reduce the impulsive behaviour of children and to improve their self-regulation. Methods The protocol was centred on awareness of the present moment, defusion and acceptance of feelings and emotions. Behavioural (Conners' Parent Rating Scale -Revised: Long version, CPRS-R:L) and severity measures (Clinical Global Impression -Severity, CGI-S) were assessed before and after treatment in a clinical sample of 31 children aged 8–13 years. Results At the end of the ACT protocol, children showed significant improvement in global functioning and behavioural symptoms. There were significant improvements in the CPRS subscales Cognitive Problems (p = 0.005), Hyperactivity (p = 0.006), Perfectionism (p = 0.017), ADHD Index (p = 0.023), Global Index: Restless–Impulsive (p = 0.023), Global Index: Total (p = 0.036), DSM IV Inattentive (p = 0.029), DSM IV Hyperactive–Impulsive (p = 0.016), and DSM IV Total (p = 0.003). When controlling for the confounding effect of pharmacological therapy, comorbidities and socio-economic status, treatment maintained a significant effect on the CPRS subscales Perfectionism (partial η2 = 0.31, p < 0.01), Global Index: Restless–Impulsive (partial η2 = 0.29, p < 0.01), Global Index: Total (partial η2 = 0.31, p < 0.01), DSM IV Hyperactive–Impulsive (partial η2 = 0.20, p = 0.02). Symptom severity as rated by CGI-S scores decreased in 74.2% of the children. Conclusions This preliminary work on an Acceptance and Commitment Therapy-based child training in children affected by ADHD resulted in significant improvements, measured by a rating scale specific for ADHD

Obra interactiva: tecnología y participación como constructores de sentido

El presente trabajo recoge la producción de la obra Lenguaje Inclusivo, instalación interactiva realizada en el año 2019 por estudiantes de la Facultad de Artes de la UNLP, en el marco de la asignatura Lenguaje Multimedial II. La obra trata la temática del lenguaje inclusivo abordando la participación como aspecto clave. Su configuración invita a descubrir una simulación visual y sonora que propone un discurso abstracto, alrededor de las mecánicas sociales que nos atraviesan en relación al lenguaje y a la resistencia de su aceptación, así como el impacto de la percepción en la construcción de realidades. La obra posibilita al espectador verse inmerso en un universo en el cual su presencia es constitutiva de los elementos visuales proyectados, así como parte de las secuencias sonoras que aluden a la manera en que nuestras acciones repercuten sobre los demás. Trabajamos en este análisis la relación de esta obra con las propuestas de endoestética de Claudia Giannetti (2005) en cuanto al rol del receptor en la experiencia artística en la que se encuentran profundamente integradas las nuevas tecnologías, así como las ideas de Jesús Martín Barbero (2003) respecto de la incidencia de los medios digitales en la cultura.Facultad de Arte