La autonomía de voluntad de los menores de edad

Treballs Finals de Grau de Dret. Universitat de Barcelona. Curs: 2014-2015. Tutora: Teresa Duplá Marín

La cultura del videojuego en la educación: una propuesta didáctica audiovisual para el alumnado de infantil

En la nueva sociedad de la información, dónde las nuevas tecnologías han adquirido un papel fundamental, los “jóvenes nativos digitales” requieren herramientas que les permitan cubrir sus nuevas necesidades de aprendizaje desde los primeros momentos de escolarización. El presente trabajo trata de reflejar como los videojuegos, pueden ser utilizados como una herramienta educativa que permita cubrir las necesidades de esta nueva generación, con grandes beneficios en el proceso de enseñanza-aprendizaje. El trabajo presenta una propuesta de intervención en la que se pretende, a través de los videojuegos, desarrollar una nueva herramienta didáctica que pueda ayudar al docente en su práctica, de una manera innovadora, tratando de fomentar el interés y resaltando la importancia que tiene incorporar, en el sistema educativo, las nuevas tecnologías para el desarrollo pleno de los alumnos

Molecular mechanisms of hypertensive nephropathy: Renoprotective effect of losartan through hsp70

Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease after diabetes. For years, hypertensive kidney disease has been focused on the afferent arterioles and glomeruli damage and the involvement of the renin angiotensin system (RAS). Nonetheless, in recent years, novel evidence has demonstrated that persistent high blood pressure injures tubular cells, leading to epithelial–mesenchymal transition (EMT) and tubulointerstitial fibrosis. Injury primarily determined at the glomerular level by hypertension causes changes in post-glomerular peritubular capillaries that in turn induce endothelial damage and hypoxia. Microvasculature dysfunction, by inducing hypoxic environment, triggers inflammation, EMT with epithelial cells dedifferentiation and fibrosis. Hypertensive kidney disease also includes podocyte effacement and loss, leading to disruption of the filtration barrier. This review highlights the molecular mechanisms and histologic aspects involved in the pathophysiology of hypertensive kidney disease incorporating knowledge about EMT and tubulointerstitial fibrosis. The role of the Hsp70 chaperone on the angiotensin II–induced EMT after angiotensin II type 1 receptor (AT1R) blockage, as a possible molecular target for therapeutic strategy against hypertensive renal damage is discussed.Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Gil Lorenzo, Andrea Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Vallés, Patricia G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentin

PERROS DE TERAPIA Y ASISTENCIA PARA NIÑOS CON AUTISMO

El objetivo principal de este trabajo es aportar más información acerca de los perros de terapia y de asistencia para niños con autismo y cuál es el motivo por el cual no son utilizados comúnmente a pesar de los múltiples beneficios que este supone para los niños que sufren del Trastorno del Espectro Autista. Además de la información relacionada con este trastorno también se puede encontrar datos referentes a otro tipo de perros utilizados para personas que tienen otras necesidades como perros de alerta médica para personas diabéticas o alérgicas a ciertos alimentos, perros señal para personas sordas, etc. Gracias a esta información, podemos llegar a la conclusión de que a pesar de todos los riesgos y precauciones que se deben tomar al trabajar con animales es beneficioso llevar a cabo este tipo de terapias

The role of the complement system in pediatric patients with typical Hemolytic Uremic Syndrome

Introducción: el Síndrome Urémico Hemolítico (SUH) es la principal causa de fallo renal agudo en pacientes pediátricos en Argentina. La toxina Shiga es capaz de activar la vía alterna del complemento in vitro. Objetivo: estudiar la participación del sistema de complemento en la patogénesis del SUH típico y relacionar alteraciones genéticas del mismo con la respuesta clínica inicial

Risk Factors for Sporadic Shiga Toxin–producing Escherichia coli Infections in Children, Argentina1

These infections can be prevented by avoiding known risk factors

Unpacking the Role of Work Demands in Teacher Burnout: Cognitive Effort as a Protective Factor

Introduction: This paper contributes to the research on teacher burnout by distinguishing between two aspects of work demands that are usually merged in the 'workload' construct: the quantity of the demands (quantitative demands) and the cognitive effort they require (cog-nitive demands). Such a distinction may offer insight into how educational administrators should manage certain types of work demands. Method: In an international sample of 209 kindergarten, primary and lower secondary teachers working in 110 schools from four different countries (Brazil, Chile, Ecuador, and Spain), we administered the Maslach Burnout Inventory (MBI) and the Copenhagen Psychosocial Questionnaire II (COPSOQII). We conducted three separate multiple regressions in which the work conditions (COPSOQII) were set (forced entry) as predictors of emotional exhaustion, depersonalization, and personal accomplishment (MBI). Results: We found that quantitative and cognitive demands predict teacher burnout differently: while quantitative demands predict emotional exhaustion and depersonalization, cognitive demands play a protective role in relation to those two components and also predict personal accomplishment. Additionally, we found that emotional demands positively predict emotional exhaustion and depersonalization, and negatively predict personal accomplishment. We also foud that support from colleagues and community positively predicts personal accomplishment, but shows no significant relationship with either emotional exhaustion or depersonalization. Discussion and Conclusion: Results suggest that the distinction between the quantity of demands and the cognitive effort they require is meaningful and important for future research and practice in the field of teaching. One important implication for educational administration is that the quantity of work assigned to teachers should be kept relatively low but, at the same time, this work should be cognitively activating and demanding

Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium.

Rocuronium (ROC) and Vecuronium (VEC) are the most currently used steroidal non-depolarizing neuromuscular blocking (MNB) agents. Sugammadex (SUG) rapidly reverses steroidal NMB agents after anaesthesia. The present study was conducted in order to evaluate neuronal effects of SUG alone and in combination with both ROC and VEC. Using MTT, CASP-3 activity and Western-blot we determined the toxicity of SUG, ROC or VEC in neurons in primary culture. SUG induces apoptosis/necrosis in neurons in primary culture and increases cytochrome C (CytC), apoptosis-inducing factor (AIF), Smac/Diablo and Caspase 3 (CASP-3) protein expression. Our results also demonstrated that both ROC and VEC prevent these SUG effects. The protective role of both ROC and VEC could be explained by the fact that SUG encapsulates NMB drugs. In BBB impaired conditions it would be desirable to control SUG doses to prevent the excess of free SUG in plasma that may induce neuronal damage. A balance between SUG, ROC or VEC would be necessary to prevent the risk of cell damag

Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes. IL-3 is involved in inflammation and ABDF1 intervenes normally in the transport across cell membranes and both were found up-regulated in APP/PS1 mice compared to Wild type mice. Furthermore, CCR5 expression was decreased and both CCL3 and CCL4 chemokines were highly expressed indicating a possible gliosis and probably an increase in chemotaxis from lymphocytes and T cell generation. We also noted for the first time, a CCR8 increase expression with diminution of its CCL1 chemokine, both normally involved in protection from bacterial infection and demyelination. Control of inflammatory proteins will be the next step in understanding the progression of AD and also in determining the mechanisms that can develop in this disease