Modifying the Escalera Consent Decree: A Case Study on the Application of the Rufo Test

This Note argues that modifying the Escalera degree is appropriate under Rufo and would allow NYCHA to maintain a safe environment for its residents. It expains the standard used in modifying a consent decree, pre- and post-Rufo, as well as the difficulties in applying the Rufo test. It traces the history of the Escalera Consent Decree, outlines the arguments for and against modification, and applies Rufo to the proposed modification of Escalera, arguing that modification is appropriate because the facts have changed significantly since the Decree was signed, and the modification sought is appropriately tailored to those changed circumstances

Anomaly Detection in Paleoclimate Records using Permutation Entropy

Permutation entropy techniques can be useful in identifying anomalies in paleoclimate data records, including noise, outliers, and post-processing issues. We demonstrate this using weighted and unweighted permutation entropy of water-isotope records in a deep polar ice core. In one region of these isotope records, our previous calculations revealed an abrupt change in the complexity of the traces: specifically, in the amount of new information that appeared at every time step. We conjectured that this effect was due to noise introduced by an older laboratory instrument. In this paper, we validate that conjecture by re-analyzing a section of the ice core using a more-advanced version of the laboratory instrument. The anomalous noise levels are absent from the permutation entropy traces of the new data. In other sections of the core, we show that permutation entropy techniques can be used to identify anomalies in the raw data that are not associated with climatic or glaciological processes, but rather effects occurring during field work, laboratory analysis, or data post-processing. These examples make it clear that permutation entropy is a useful forensic tool for identifying sections of data that require targeted re-analysis---and can even be useful in guiding that analysis.Comment: 15 pages, 7 figure

Localizing the Neural Substrate of Reflexive Covert Orienting

The capture of covert spatial attention by salient visual events influences subsequent gaze behavior. A task irrelevant stimulus (cue) can reduce (Attention capture) or prolong (Inhi-bition of return) saccade reaction time to a subsequent target stimulus depending on the cue-target delay. Here we investigated the mechanisms that underlie the sensory-based account of AC/IOR by manipulating the visual processing stage where the cue and target interact. In Experiment 1, liquid crystal shutter goggles were used to test whether AC/IOR occur at a monocular versus binocular processing stage (before versus after signals from both eyes converge). In Experiment 2, we tested whether visual orientation selective mechanisms are critical for AC/IOR by using oriented “Gabor” stimuli. We found that the magnitude of AC and IOR was not different between monocular and interocular viewing conditions, or between iso- and ortho-oriented cue-target interactions. The results suggest that the visual mechanisms that contribute to AC/IOR arise at an orientation-independent binocular processing stage

Exploring Nursing Students\u27 Perceptions of Electronic Fetal Monitoring App

Within the healthcare realm, innovative technology has become an integral part of teaching in today’s nursing education, specifically computer-generated teaching applications. A new application that combines both nursing simulation and teaching methods regarding electronic fetal monitoring and fetal heart rhythms was developed at the University of Tennessee in fall 2014.This application was created in collaboration with both the College of Engineering and the College of Nursing. The Electronic Fetal Monitoring App displays instructor-created fetal heart rate (FHR) and maternal contraction patterns to simulate a monitor enabling live- feed interpretation in the classroom or simulation setting. It also has the potential to be saved and recreated for further simulated learning experiences. With current nursing education using processes such as application involvement and simulation in the clinical environment, the evolvement and merger of simulation and technology applications has the potential to exponentially benefit patient outcomes. Therefore, with the creation of a novel simulation application incorporated into the classroom setting, the purpose of this qualitative descriptive study is to explore nursing students’ learning experiences, attitudes, perceptions, and opinions regarding a fluid, dynamic, instructor-manipulated EFM application

Using Nuclear Magnetic Resonance Spectroscopy to Develop Physiological Profiles for Bighorn Sheep (Poster)

This study employs new techniques using nuclear magnetic resonance (NMR) to assess the relative health, physiological condition, and reproductive function of wild bighorn sheep (Ovis canadensis) in Montana and Wyoming. Ongoing bighorn studies in Montana and the Greater Yellowstone Ecosystem are focused on herd attributes and the population dynamics which are affected by disease, climate, habitat and physiology. Indices of herd health and physiological status are typically obtained through expensive and time consuming lab assays and field measurements. Recently, NMR spectroscopy has been used to revolutionize the assessment of human metabolic health, and we expect that there is similar potential for studies of wildlife populations. Using NMR spectroscopy to assess metabolites associated with disease, nutrition and stress may eliminate the need for many traditional assays and techniques used today. NMR can be used to evaluate a large suite of metabolites associated with a variety of physiological functions from as little as 500 uL of serum or plasma. Blood samples from 242 sheep from 13 different herds were collected during the winters of 2013-14 and 2014-15 to develop a comprehensive metabolite panel for bighorn sheep. We have used a recently developed statistical program known as MetaboAnalyst™ to begin to analyze and evaluate differences in NMR metabolic profiles among herds and across the fall-winter season when nutritional and physiological stress is expected to be acute. We will be presenting the results of this preliminary study and discussing the potential for application in wildlife management

Nuclear Magnetic Resonance Spectroscopy Metabolic Profiles to Distinguish Geographically Isolated Populations of Mountain Goats

Basic physiological studies on mountain goats (Oreamnos americanus) are conspicuously lacking in the literature, and the physiology of this species is perhaps the least known of the high mountain ungulates. The objective of this study was to evaluate metabolic profiles of female mountain goats from five geographically distinct populations using Nuclear Magnetic Resonance (NMR) spectroscopy. Serum samples were collected from nannies located in Alaska in September (AK) from Glacier in August (GMT), from the Grand Tetons in November-December (GT), from NE Yellowstone in December (NEY) and from Absaroka in March (AB). Serum was extracted with acetone, dried and re-suspended in a standard NMR buffer. NMR spectra were analyzed with Chenomix™ software. Metabolites were identified and concentrations determined using the Chenomix™ database and the Human Metabolome Database. We identified 55 metabolites in the serum of mountain goats using this emerging technology. Of these 42 metabolites differed among the herds (P < 0.05). Of these 42 metabolites; creatinine, lactate and pyruvate distinguished (P < 0.05) each herd from another. Furthermore, using Principal Component Analyses of these metabolites allowed us to clearly differentiate metabolic profiles in carbohydrate, protein and lipid metabolism in nannies from these five populations. This study has the potential to enhance our understanding of how changes in nutrition, reproduction, susceptibility to disease, and survival rates drive population dynamics

The novel histone deacetylase inhibitor, AR-42, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells

Multiple myeloma (MM) remains incurable with current therapy, indicating the need for continued development of novel therapeutic agents. We evaluated the activity of a novel phenylbutyrate-derived histone deacetylase inhibitor, AR-42, in primary human myeloma cells and cell lines. AR-42 was cytotoxic to MM cells at a mean LC(50) of 0.18 ± 0.06 μmol/l at 48 hr and induced apoptosis with cleavage of caspases 8, 9 and 3, with cell death largely prevented by caspase inhibition. AR-42 downregulated the expression of gp130 and inhibited activation of STAT3, with minimal effects on the PI3K/Akt and MAPK pathways, indicating a predominant effect on the gp130/STAT-3 pathway. AR-42 also inhibited interleukin (IL)-6-induced STAT3 activation, which could not be overcome by exogenous IL-6. AR-42 also downregulated the expression of STAT3-regulated targets, including Bcl-xL and cyclin D1. Overexpression of Bcl-xL by a lentivirus construct partly protected against cell death induced by AR-42. The cyclin dependent kinase inhibitors, p16 and p21, were also significantly induced by AR-42, which together with a decrease in cyclin D1, resulted in G(1) and G(2) cell cycle arrest. In conclusion, AR-42 has potent cytotoxicity against MM cells mainly through gp130/STAT-3 pathway. The results provide rationale for clinical investigation of AR-42 in MM

ENSO and Variability of the Antarctic Peninsula Pelagic Marine Ecosystem

The West Antarctic Peninsula region is an important source of Antarctic krill (Euphausia superba) in the Southern Ocean. From 1980-2004 abundance and concentration of phytoplankton and zooplankton, krill reproductive and recruitment success and seasonal sea ice extent here were significantly correlated with the atmospheric Southern Oscillation Index and exhibited three- to five-year frequencies characteristic of El Nino-Southern Oscillation (ENSO) variability. This linkage was associated with movements of the Southern Antarctic Circumpolar Current Front and Boundary, a changing influence of Antarctic Circumpolar Current and Weddell Sea waters, and eastward versus westward flow and mixing processes that are consistent with forcing by the Antarctic Dipole high-latitude climate mode. Identification of hydrographic processes underlying ecosystem variability presented here were derived primarily from multidisciplinary data collected during 1990-2004, a period with relatively stable year-to-year sea ice conditions. These results differ from the overwhelming importance of seasonal sea ice development previously established using 1980-1996 data, a period marked by a major decrease in sea ice from the Antarctic Peninsula region in the late 1980s. These newer results reveal the more subtle consequences of ENSO variability on biological responses. They highlight the necessity of internally consistent long-term multidisciplinary datasets for understanding ecosystem variability and ultimately for establishing well-founded ecosystem management. Furthermore, natural environmental variability associated with interannual- and decadal-scale changes in ENSO forcing must be considered when assessing impacts of climate warming in the Antarctic Peninsula-Weddell Sea region

Using Nuclear Magnetic Resonance (NMR) Metabolic Profiling to Distinguish Herds of Bighorn Sheep

The objective of this study was to determine if nuclear magnetic resonance (NMR) metabolic profiling has the potential to serve as a management tool for evaluating herds of bighorn (Ovis canadensis) sheep. Two-hundred and forty bighorn sheep serum samples from 13 herds located in Montana and Wyoming were processed for NMR spectra, profiled for small molecule metabolites using Chenomx®, and then analyzed with MetaboAnalyst (v3.0). Fifty-six small molecule metabolites were identified in ungulate serum.  To determine if NMR metabolic profiles can distinguish herds that are geographically distinct with access to different nutritional resources, herds collected in December were compared to herds collected in March. Partial least square discriminant analysis (PLS-DA) indicated a clear, majority separation of metabolic shifts with minor overlaps. Biomarker analysis identified 15 potential biomarkers from the compounds with variables of importance (VIP) scores greater than 1.0. These molecules enabled us to identify ‘significantly’ important metabolic pathways that discriminate herds sampled in December and herds sampled in March. Key biomarkers resulting from the pathway analysis, included: 2-oxoisocaproate, choline, tyrosine, creatinine, and trimethylamine n-oxide. To determine if metabolic profiling can distinguish individual herds within a month, herds in December, January and March were compared to a domestic, Rambouillet ewes (control) sampled during the sample months.  PLS-DA of all herds showed clear metabolic shifts and complete separation between each individual herd and the control ewes for each month. Potential biomarkers for herds within a season that were found to be good discriminants for the December herds included: trimethylamine n-oxide and sarcosine; for January herds included: creatinine and asparagine; and, for March herd included, creatinine. Through identification of small molecule metabolites, it is possible to discriminate herds from each other within and between seasons. These biomarkers represent a potential panel of metabolites that may be used for assessing nutritional status, environmental stress, and herd health through the identification of significantly important metabolic pathways related to energy and protein balance

Researchers’ green Open Access practice: a cross-disciplinary analysis

The EC-funded Publishing and the Ecology of European Research (PEER) project (http://www.peerproject.eu/) is an unprecedented collaboration between stakeholders involved in scholarly research and scholarly publishing, looking into specific aspects of the complex relationship between Open Access (OA) and scholarly communication. The project includes publishers and representatives, libraries, open access repositories (OARs) and researchers themselves, both as authors of journal articles and as readers (or consumers) of journal literature. The behavioural research is one of three strands that form the PEER Observatory, which was set up to investigate the effects of the large scale deposit of stage-two manuscripts (also known as authors’ final peer-reviewed and accepted manuscripts) on reader access, journal visibility and viability, and the broader ecology of European research (Shepherd & Wallace, 2009). The PEER behavioural research project was carried out in two phases, between April and September 2009, and from September 2010 to August 2011. Researchers at Loughborough University examined the behavioural aspects affecting self-archiving of stage-two manuscripts in OARs as well as the use of these manuscripts by fellow researchers. Most discussion of Open Access recognises the two main mechanisms to achieving open access. The gold route, often referred to as the ‘author pays’ route, involves payment of an article processing charge to publishers enabling the article to be made available to all without subscription or charge barriers. The alternative green route, often referred to as the ‘self archiving’ route, entails authors submitting manuscripts to traditional journals but maintaining the right to mount a version of their work on an open access repository. Much debate has focussed on the most effective way to achieve Open Access. There are many advocates of the green self archiving route to OA; subject-based repositories containing both stage-two manuscripts and preprints of research articles are a widely accepted development in certain disciplines such as physics and economics. Alongside this, many institutions are developing their own open access repositories and some are mandating deposit into these respositories. ROARMAP (http://roarmap.eprints.org/) and OpenDOAR (http://www.opendoar.org/) outline the extent of these developments worldwide. On the other hand, the recent report by the Working Group on Expanding Access to Published Research Findings, chaired by Professor Dame Janet Finch (Working Group on Expanding Access to Published Research Findings, 2012) recommended developing clear policies in support of publication in Open Access journals. In recommending gold OA, the Finch report requests that repositories carefully consider the balance between the aims of open access and possible risks ‘to the sustainability of subscription-based journals during what is likely to be a lengthy transition to open access’, however the report does recommend the continual development of the infrastructure surrounding subject and institutional repositories, though primarily for the purposes of research data and grey literature. In the lights of current policy developments in favour of the different routes to Open Access, a cross disciplinary analysis of researcher’s views and attitudes towards green (self archiving) OA practice is timely. Based on Phase 2 of the project, this article extends the preliminary results from phase 1 reported in Creaser et al (2010), and further develops understanding of researchers’ green OA experience both as authors and readers of peer-reviewed journal articles by looking in greater detail at their reported use of OARs and the context of that use. The article identifies disciplinary patterns of behaviour at the level of the Medical sciences, Life sciences, Physical sciences & mathematics, and Social sciences, humanities & arts in order to better understand the role of OARs in the scholarly communication landscape