Harmonização do sorriso gengival com toxina botulínica: revisão narrativa

O sorriso gengival pode ser um obstáculo superável para aqueles pacientes que idealizam um determinado padrão de beleza. Para alguns pacientes, a exposição excessiva de gengiva além de poder interferir na sua autoestima, coexiste com disfunções do Sistema Estomatognático (SE). A etiologia é multifatorial, podendo existir uma sobreposição de fatores causais como erupção dentária anormal, hiperatividade do músculo elevador do lábio superior ou crescimento vertical excessivo do osso maxilar. Consequentemente, a escolha do tratamento adequado reside por vezes na combinação de modalidades terapêuticas. Os procedimentos utilizados podem ser cirúrgicos ou não cirúrgicos, sendo que o recurso ao uso da toxina botulínica (TB) é considerado uma opção pouco invasiva e segura, que tem vindo a ser usada com sucesso nos últimos anos. Esta revisão bibliográfica tem como objectivo analisar as publicações acerca do uso da toxina botulínica no tratamento do sorriso gengival.The gingival smile can be an overcomable obstacle for those patients, who idealize a certain beauty standard. In some patients, excessive gingival exposure, in addition to being able to interfere with their self-esteem, sometimes coexists with Stomatognathic System (SE) dysfunctions. The etiology is multifactorial, and there may be an overlap of causal factors such as abnormal dental eruption, hyperactivity of the upper lip elevator muscle or excessive vertical growth of the maxillary bone. Consequently, the choice of appropriate treatment sometimes lies in the combination of therapeutic modalities. The procedures used may be surgical or non- surgical, and the use of botulinum toxin (TB) is considered a non-invasive and safe option and has been successfully used in recent years. This bibliographic review aims to analyze the publications about the use of botulinum toxin in the treatment of gingival smile

Oxidative Status of Goats with Different CSN1S1 Genotypes Fed ad Libitum with Fresh and Dry Forages

Forty late-lactation Girgentana goats were used to study the effect of diets fed ad libitum and αS1-casein (CSN1S1) genotype on redox balance. The goats genotyped at CSN1S1 locus (A/A, A/F) were subjected to four feeding treatments different for percentage inclusion of dry and fresh forage: DAF100 (98% of Dry Alfalfa Forage), DAF65 (65% of Dry Alfalfa Forage), FSF100 (100% of Fresh Sulla Forage) and FSF65 (65% of Fresh Sulla Forage). Blood samples were analyzed for superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity, reactive oxygen metabolites (ROMs), biological antioxidant potential (BAP) and non-esterified fatty acids (NEFA), beta-hydroxybutyrate (BHBA), albumin, glucose and cholesterol contents. The oxidative stress index (OSI) was calculated as percentage ratio of ROMs to BAP. Redox balance was improved by Sulla inclusion, as reflected in the lower OSI values found in FSF100 and FSF65 groups. DAF100 group displayed the highest GPX activity, while other groups exhibited the highest SOD activity. Fresh forage diets increased albumin concentration while no effect of tested factors was noted on glucose, NEFA, BHBA and cholesterol contents. The interaction diet × genotype was significant only for GPX activity. GPX and albumin were negatively correlated and were correlated positively and negatively with ROMs, respectively. Diet rather than genotype affects redox balance in dairy goats and a possible role of forage polyphenol compounds on oxidative status needs to be tested in future studies

Carbon Quantum Dots as Fluorescence Nanochemosensors for Selective Detection of Amino Acids

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The impact of environmental factors in influencing epigenetics related to oxidative states in the cardiovascular system

Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions. When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental. Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeostasis. Current advances in our understanding of epigenetics have revealed a parallel scenario showing the influence of oxidative stress as a major regulator of epigenetic gene regulation via modification of DNA methylation, histones, and microRNAs. This has provided both the biological link and a potential molecular explanation between oxidative stress and cardiovascular/metabolic phenomena. Accordingly, in this review, we will provide current insights on the physiological and pathological impact of changes in oxidative states on cardiovascular disorders, by specifically focusing on the influence of epigenetic regulation. A special emphasis will highlight the effect on epigenetic regulation of human's current life habits, external and environmental factors, including food intake, tobacco, air pollution, and antioxidant-based approaches. Additionally, the strategy to quantify oxidative states in humans in order to determine which biological marker could best match a subject's profile will be discussed

The Role of Eye Gaze in Subjective Decision Making

Shimojo, Simion, Shimojo and Scheier (2003) provided preliminary evidence that eye movements have an active role in preference formation. In their study, subjects were presented with two faces and chose which was more attractive. By manipulating how long subjects were able to look at each face after an eye movement, Shimojo et al. (2003) showed that faces presented for a longer duration were more likely to be chosen as more attractive. However, a recent study from Nittono and Wada (2009) showed that an eye movement may not be necessary for this effect, as novel graphic patterns presented in the centre of the screen (thus requiring no eye movements) for longer durations were also more likely to be preferred. The purpose of the current study was to further investigate whether eye movements do have an active role in preference formation. The present study used the same paradigm as Shimojo et al.’s (2003) study. Subjects in Experiment 1 were presented with images of two real faces, alternatively (one for 900ms, one for 300ms) for six repetitions. There were 3 independent experimental conditions. One group were required to make eye movements to laterally presented faces and judge attractiveness (lateral attractiveness condition), a second were not required to make eye movements to centrally presented faces and judge attractiveness (central attractiveness condition). The third were required to make eye movements to laterally presented faces and judge roundness (lateral roundness condition). The findings indicated that subjects were more likely to choose the longer presented faces in the lateral attractiveness and central attractiveness conditions, but not the lateral roundness conditions. Experiment 2 was similar to Experiment 1 with the exception of the type of stimuli, which consisted of computer generated faces (CGFs). Subjects were more likely to choose the longer presented CGF in the lateral attractiveness, central attractiveness and lateral roundness conditions. The findings of the present study were not in line with Shimojo et al.’s (2003) previous findings, who found that faces presented for a longer duration were only preferred in the lateral attractiveness condition of their study. It is possible that the faces that are presented for the longer duration in the current paradigm are preferred due to the increase in exposure duration irrespective of an eye movement (as per the findings from Nittono and Wada, 2009). As it is unclear as to whether eye movements play an active role in preference formation, the findings of the present study have not been able to contribute to computational models of decision making

Impact of tiered restrictions on human activities and the epidemiology of the second wave of COVID-19 in Italy

To counter the second COVID-19 wave in autumn 2020, the Italian government introduced a system of physical distancing measures organized in progressively restrictive tiers (coded as yellow, orange, and red) imposed on a regional basis according to real-time epidemiological risk assessments. We leverage the data from the Italian COVID-19 integrated surveillance system and publicly available mobility data to evaluate the impact of the three-tiered regional restriction system on human activities, SARS-CoV-2 transmissibility and hospitalization burden in Italy. The individuals' attendance to locations outside the residential settings was progressively reduced with tiers, but less than during the national lockdown against the first COVID-19 wave in the spring. The reproduction number R(t) decreased below the epidemic threshold in 85 out of 107 provinces after the introduction of the tier system, reaching average values of about 0.95-1.02 in the yellow tier, 0.80-0.93 in the orange tier and 0.74-0.83 in the red tier. We estimate that the reduced transmissibility resulted in averting about 36% of the hospitalizations between November 6 and November 25, 2020. These results are instrumental to inform public health efforts aimed at preventing future resurgence of cases

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription