Periferias conservadoras : un análisis comparativo de la evolución del conservadurismo argentino

La presente tesis doctoral aborda la posición politica de la derecha argentina en dos coyunturas históricas especificas, mediante comparaciones sincrónicas y diacrónicas de los resultados electorales de la derech

Machiavelli in contemporary science policy: basis and limitations of an intelectual recognition

Almost five hundred years after his death, Machiavelli’s work still exerts a strong influence on the analysis of political phenomena and the development of political theory. This article examines the reasons and limitations of the continuing power of Machiavelli’s discourse in two specific fields of contemporary political science: comparative politics, and political theory. Our analysis explores also, from a contemporary perspective, the methodological and ontological value of Machiavelli’s contribution to the study of politics.Casi cinco siglos después de su muerte, las ideas de Nicolás Maquiavelo continúan siendo una referencia para el análisis de fenómenos políticos de las más diversas índoles y para la discusión política de carácter teórico. Este artículo pretende reflejar el poder de permanencia del discurso maquiaveliano en dos ámbitos específicos de la ciencia política: la política comparada y la teoría política. Además, esta reflexión sugerirá aprendizajes de carácter más abstracto y general, metodológicos y ontológicos, que podemos seguir derivando de la obra maquiaveliana

Correlation between clinical findings and magnetic resonance imaging for the assessment of local response after standard treatment in cervical cancer

AbstractBackgroundThe aim of our study is to evaluate the correlation between gynecological examination and magnetic resonance (MRI) findings for the assessment of local response in cervical cancer patients treated with radiotherapy/chemotherapy (RT/ChT).Patients and methodsThis study is a retrospective review of 75 consecutive cervical cancer patients from April 2004 to November 2009 treated with RT/ChT. Clinical and radiological data were subsequently analyzed. Patient's median age was 51 with a FIGO stage from Ib to IVb. Individualized RT/ChT was administered with a median dose of 45Gy. Sixty-three patients received a complementary brachytherapy. Seventy-one patients received chemotherapy on a weekly basis. Gynecological exam was performed 3 months and 6 months after treatment and these findings were compared to MRI results at the same time.Statistic analysisWe used the Spearman's Rho test to determine the correlation level between the clinical and radiological methods.ResultsA correlation of 0.68 (60%) was observed between the clinical and MRI findings at 3 months with a further increase of up to 0.86 (82.6%) at 6 months. In the few cases with a poor correlation, the subsequent assessment and the natural history of the disease showed a greater value of the clinical exam as compared with the MRI findings.ConclusionsPhysical exam remains an essential tool to evaluate the local response to RT/ChT for cervical cancer. The optimal clinical radiological correlation found at 6 months after treatment suggests that the combination of gynecological examination and MRI are probably adequate in patient monitoring

Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker

Simple Summary: Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous cell carcinoma (HNSCC) is associated with disease and treatmentrelated morbidity so there is an urgent need for innovation in treatment and diagnosis practices. Our aim was to evaluate the potential of the succinate-related pathway as a diagnostic and prognostic biomarker in HNSCC. The circulating succinate levels are increased in HNSCC, being a potential noninvasive biomarker for HNSCC diagnosis. Moreover, the succinate receptor (SUCNR1) and genes related to succinate metabolism, which are predominantly expressed in the tumoral mucosa as compared with healthy tissue, are positively associated with plasma succinate. Remarkably, we found that SUCNR1 and SDHA expression levels predict prognosis

Residual Enhancing Disease after Surgery for Glioblastoma: Evaluation of Practice in the United Kingdom

Background A growing body of clinical data highlights the prognostic importance of achieving gross total resection (GTR) in patients with glioblastoma. The aim of this study was to determine nationwide practice and attitudes towards achieving GTR and dealing with residual enhancing disease. Methods The study was in 2 parts: an electronic questionnaire sent to United Kingdom neuro-oncology surgeons to assess surgical practice followed by a 3-month prospective, multicenter observational study of current neurosurgical oncology practice. Results Twenty-seven surgeons representing 22 neurosurgical units completed the questionnaire. Prospective data were collected for 113 patients from 15 neurosurgical units. GTR was deemed to be achieved at time of surgery in 82% (91/111) of cases, but in only 45% (36/80) on postoperative MRI. Residual enhancing disease was deemed operable in 16.3% (13/80) of cases, however, no patient underwent early repeat surgery for residual enhancing disease. The most commonly cited reason (38.5%, 5/13) was perceived lack of clinical benefit. Conclusion There is a subset of patients for whom GTR is thought possible, but not achieved at surgery. For these patients, early repeat resection may improve overall survival. Further prospective surgical research is required to better define the prognostic implications of GTR for residual enhancing disease and examine the potential benefit of this early re-intervention

Diseño y elaboración de bases de datos de consulta on-line de ayuda a la docencia en las Ciencias Sociales

Memoria ID-0197. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

Las transformaciones ideológicas del discurso liberal—conservador en la Argentina contemporánea: un examen del pensamiento político de Federico Pinedo y Alvaro Alsogaray

[ES] A través de este artículo, Iván Llamazares examina algunos de los rasgos principales de la evolución de la ideología liberal-conservadora durante el presente siglo. Con este fin, en el mismo se presentan algunas características básicas del pensamiento político de Federico Pinedo y Alvaro Alsogaray, dos políticos liberal-conservadores que representan muy bien las características principales del liberalismo conservador antes y después del surgimiento del peronismo.[EN] Through this article, Iván Llamazares examines some of the mean characteristics of the liberalconservative ideology evolution along this century. With this aim, some basic features of Federico Pinedo's and Alvaro Alsogaray's political thought are shown. These two liberal-conservative political men are representative of the conservative liberalism before and after the emergente of peronism

Las transformaciones ideológicas del discurso liberal—conservador en la Argentina contemporánea: un examen del pensamiento político de Federico Pinedo y Alvaro Alsogaray

<p>RESUMEN: A través de este artículo, Iván Llamazares examina algunos de los rasgos principales de la evolución de la ideología liberal-conservadora durante el presente siglo. Con este fin, en el mismo se presentan algunas características básicas del pensamiento político de Federico Pinedo y Alvaro Alsogaray, dos políticos liberal-conservadores que representan muy bien las características principales del liberalismo conservador antes y después del surgimiento del peronismo.</p><p>ABSTRACT: Through this article, Iván Llamazares examines some of the mean characteristics of the liberalconservative ideology evolution along this century. With this aim, some basic features of Federico Pinedo's and Alvaro Alsogaray's political thought are shown. These two liberal-conservative political men are representative of the conservative liberalism before and after the emergente of peronism.</p