Static solitons with non-zero Hopf number

We investigate a generalized non-linear O(3) $\sigma$-model in three space dimensions where the fields are maps $S^3 \mapsto S^2$. Such maps are classified by a homotopy invariant called the Hopf number which takes integer values. The model exhibits soliton solutions of closed vortex type which have a lower topological bound on their energies. We explicitly compute the fields for topological charge 1 and 2 and discuss their shapes and binding energies. The effect of an additional potential term is considered and an approximation is given for the spectrum of slowly rotating solitons.Comment: 13 pages, RevTeX, 7 Postscript figures, minor changes have been made, a reference has been corrected and a figure replace

The International Virus Bioinformatics Meeting 2023

The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment conducive to discussion, collaboration, and the generation of novel research ideas. As the first in-person event following the SARS-CoV-2 pandemic, the meeting facilitated highly interactive exchanges among attendees. It served as a pivotal gathering for gaining insights into the current status of virus bioinformatics research and engaging with leading researchers and emerging scientists. The event comprised eight invited talks, 19 contributed talks, and 74 poster presentations across eleven sessions spanning three days. Topics covered included machine learning, bacteriophages, virus discovery, virus classification, virus visualization, viral infection, viromics, molecular epidemiology, phylodynamic analysis, RNA viruses, viral sequence analysis, viral surveillance, and metagenomics. This report provides rewritten abstracts of the presentations, a summary of the key research findings, and highlights shared during the meeting

New Disturbing Trend in Antimicrobial Resistance of Gram-Negative Pathogens

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Bibliometric and Retrospective Analysis on Economic Behavior for Inclusive Growth

The article provides a bibliometric analysis of existing publications on the market participants’ behavior(manufacturers, trading companies, and other intermediaries and consumers). The basis for the study is the Scopus database, which presents publications on this topic for over thirty years. The article aims to study the research directions on behavioral models of economic entities and the factors that influence their formation. Such analysis can be used to determine the place of behavioral economics in the system of modern views of economists on its impact on the further global development of the economic system. By selecting the most relevant articles on the economic behavior of market participants in the context of an inclusive economy, 1198 scientific articles were selected, published in periodicals from 1989 to 2021. The clustering and retrospective analysis were chosen as a methodological study tool, performed using VOSviewer 1.6.16 software. It made it possible to obtain a clear visualization of research clusters on economic entities’ behavioral aspects, including individual periods of the enormous publication activity from 2011 to 2021. In addition, the article identifies the largest regional research networks of behavioral models in an inclusive economy. Based on the analysis of the scientific publications from the Scopus database, three periods of research on the behavioral aspects of economic entities were identified. The study of the first stage focused on e-commerce development as a significant factor in market changes, accompanied by the transition of competition from local to global. The next phase of the economic behavior study was accompanied by the sustainable development concept and changes in consumer values, which influenced the choice of suppliers and service providers and the growing importance of decision criteria that previously could not be considered purely economic. Considerable attention in this period of publishing activity was paid to social responsibility and sustainable consumption. The last research defined in the article stages is aimed at using modern research methods and information technologies for a deeper analysis of the subject area. It makes it possible to identify relevant factors influencing the formation of economic entities’ behavior patterns, which could not be determined before

The possibilities and reserves of the diagnostic, therapeutical and prophylaxy approaches of primary hypertension in family doctors practice of Poltava region

Резюме У статті наведено результати аналізу 835 амбулаторних карт, наданих районними центрами первинної медико-санітарної допомоги, з якості проведення лікувально-профілактичних заходів пацієнтам із гіпертонічною хворобою на Полтавщині. Проаналізовано наявні недоліки з організації й проведення профілактики та лікування артеріальної гіпертензії й визначено шляхи їх подолання. Першочерговими заходами визначено формування мотивації в лікарів і пацієнтів до найбільш ранньої терапії й профілактики артеріальної гіпертензії та вдосконалення лабораторного й інструментального забезпечення моніторингу клінічного перебігу артеріальної гіпертензії.; Summary High Public Educational Institution of Ukraine «Ukrainian Medical Stomatological Academy», Poltava, Health Care Department of Regional Public Administration of Poltava Region, Regional Clinical Cardiological Centre of Poltava 835 out-patients medical cards that were presented by the regional centers of primary medical-sanitarian care are involved in the analysis that estimated the quality of therapeutical and prophylaxic approaches in patients of Poltava region suffering on essential hypertension. Also the presence of deficiences in organisation and implementation of prophylaxical and treatment strategies in arterial hypertension and the ways of their correction were evaluated. The primary measures included encouraging motivation for doctors and patients to the early-stage treatment and prevention of hypertension and improvement of laboratory and instrumental monitoring in clinical course of this disease

Cases of Acute Flaccid Paralysis Associated with Coxsackievirus A2: Findings of a 20-Year Surveillance in the Russian Federation

Surveillance for acute flaccid paralysis syndrome (AFP) in children under 15 is the backbone of the Global Polio Eradication Initiative. Laboratory examination of stool samples from AFP cases allows the detection of, along with polioviruses, a variety of non-polio enteroviruses (NPEV). The etiological significance of these viruses in the occurrence of AFP cases has been definitively established only for enteroviruses A71 and D68. Enterovirus Coxsackie A2 (CVA2) is most often associated with vesicular pharyngitis and hand, foot and mouth disease. Among 7280 AFP cases registered in Russia over 20 years (2001–2020), CVA2 was isolated only from five cases. However, these included three children aged 3 to 4 years, without overt immune deficiency, immunized with 4–5 doses of poliovirus vaccine in accordance with the National Vaccination Schedule. The disease resulted in persistent residual paralysis. Clinical and laboratory data corresponded to poliomyelitis developing during poliovirus infection. These findings are compatible with CVA2 being the cause of AFP. Molecular analysis of CVA2 from these patients and a number of AFP cases in other countries did not reveal association with a specific phylogenetic group, suggesting that virus genetics is unlikely to explain the pathogenic profile. The overall results highlight the value of AFP surveillance not just for polio control but for studies of uncommon AFP agents