Clustering of Primordial Black Holes. II. Evolution of Bound Systems

Primordial Black Holes (PBHs) that form from the collapse of density perturbations are more clustered than the underlying density field. In a previous paper, we showed the constraints that this has on the prospects of PBH dark matter. In this paper we examine another consequence of this clustering: the formation of bound systems of PBHs in the early universe. These would hypothetically be the earliest gravitationally collapsed structures, forming when the universe is still radiation dominated. Depending upon the size and occupation of the clusters, PBH merging occurs before they would have otherwise evaporated due to Hawking evaporation.Comment: 23 pages, 1 figure. Submitted to PR

Constraints on dark matter particles charged under a hidden gauge group from primordial black holes

In order to accommodate increasingly tighter observational constraints on dark matter, several models have been proposed recently in which dark matter particles are charged under some hidden gauge group. Hidden gauge charges are invisible for the standard model particles, hence such scenarios are very difficult to constrain directly. However black holes are sensitive to all gauge charges, whether they belong to the standard model or not. Here, we examine the constraints on the possible values of the dark matter particle mass and hidden gauge charge from the evolution of primordial black holes. We find that the existence of the primordial black holes with reasonable mass is incompatible with dark matter particles whose charge to mass ratio is of the order of one. For dark matter particles whose charge to mass ratio is much less than one, we are able to exclude only heavy dark matter in the mass range of 10^(11) GeV - 10^(16) GeV. Finally, for dark matter particles whose charge to mass ratio is much greater than one, there are no useful limits coming from primordial black holes.Comment: accepted for publication in JCA

Astrophysical constraints on primordial black holes in Brans-Dicke theory

We consider cosmological evolution in Brans-Dicke theory with a population of primordial black holes. Hawking radiation from the primordial black holes impacts various astrophysical processes during the evolution of the Universe. The accretion of radiation by the black holes in the radiation dominated era may be effective in imparting them a longer lifetime. We present a detailed study of how this affects various standard astrophysical constraints coming from the evaporation of primordial black holes. We analyze constraints from the present density of the Universe, the present photon spectrum, the distortion of the cosmic microwave background spectrum and also from processes affecting light element abundances after nucleosynthesis. We find that the constraints on the initial primordial black hole mass fractions are tightened with increased accretion efficiency.Comment: 15 page

Generalised constraints on the curvature perturbation from primordial black holes

Primordial black holes (PBHs) can form in the early Universe via the collapse of large density perturbations. There are tight constraints on the abundance of PBHs formed due to their gravitational effects and the consequences of their evaporation. These abundance constraints can be used to constrain the primordial power spectrum, and hence models of inflation, on scales far smaller than those probed by cosmological observations. We compile, and where relevant update, the constraints on the abundance of PBHs before calculating the constraints on the curvature perturbation, taking into account the growth of density perturbations prior to horizon entry. We consider two simple parameterizations of the curvature perturbation spectrum on the scale of interest: constant and power-law. The constraints from PBHs on the amplitude of the power spectrum are typically in the range 10^{-2}-10^{-1} with some scale dependence.Comment: 10 pages, 2 figures, version to appear in Phys. Rev. D with minor change to calculation of constraints for spectral index not equal to on

Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

<p>Abstract</p> <p>Background</p> <p>During liver development, intrahepatic bile ducts are thought to arise by a unique asymmetric mode of cholangiocyte tubulogenesis characterized by a series of remodeling stages. Moreover, in liver diseases, cells lining the Canals of Hering can proliferate and generate new hepatic tissue. The aim of this study was to develop protocols for three-dimensional visualization of protein expression, hepatic portal structures and human hepatic cholangiocyte tubulogenesis.</p> <p>Results</p> <p>Protocols were developed to digitally visualize portal vessel branching and protein expression of hepatic cell lineage and extracellular matrix deposition markers in three dimensions. Samples from human prenatal livers ranging from 7 weeks + 2 days to 15½ weeks post conception as well as adult normal and acetaminophen intoxicated liver were used. The markers included cytokeratins (CK) 7 and 19, the epithelial cell adhesion molecule (EpCAM), hepatocyte paraffin 1 (HepPar1), sex determining region Y (SRY)-box 9 (SOX9), laminin, nestin, and aquaporin 1 (AQP1).</p> <p>Digital three-dimensional reconstructions using CK19 as a single marker protein disclosed a fine network of CK19 positive cells in the biliary tree in normal liver and in the extensive ductular reactions originating from intrahepatic bile ducts and branching into the parenchyma of the acetaminophen intoxicated liver. In the developing human liver, three-dimensional reconstructions using multiple marker proteins confirmed that the human intrahepatic biliary tree forms through several developmental stages involving an initial transition of primitive hepatocytes into cholangiocytes shaping the ductal plate followed by a process of maturation and remodeling where the intrahepatic biliary tree develops through an asymmetrical form of cholangiocyte tubulogenesis.</p> <p>Conclusions</p> <p>The developed protocols provide a novel and sophisticated three-dimensional visualization of vessels and protein expression in human liver during development and disease.</p

Primordial black holes in braneworld cosmologies: astrophysical constraints

In two recent papers we explored the modifications to primordial black hole physics when one moves to the simplest braneworld model, Randall--Sundrum type II. Both the evaporation law and the cosmological evolution of the population can be modified, and additionally accretion of energy from the background can be dominant over evaporation at high energies. In this paper we present a detailed study of how this impacts upon various astrophysical constraints, analyzing constraints from the present density, from the present high-energy photon background radiation, from distortion of the microwave background spectrum, and from processes affecting light element abundances both during and after nucleosynthesis. Typically, the constraints on the formation rate of primordial black holes weaken as compared to the standard cosmology if black hole accretion is unimportant at high energies, but can be strengthened in the case of efficient accretion.Comment: 17 pages RevTeX4 file with three figures incorporated; final paper in series astro-ph/0205149 and astro-ph/0208299. Minor changes to match version accepted by Physical Review

Cosmological constraints on primordial black holes produced in the near-critical gravitational collapse

The mass function of primordial black holes created through the near-critical gravitational collapse is calculated in a manner fairly independent of the statistical distribution of underlying density fluctuation, assuming that it has a sharp peak on a specific scale. Comparing it with various cosmological constraints on their mass spectrum, some newly excluded range is found in the volume fraction of the region collapsing into black holes as a function of the horizon mass.Comment: 9 pages. Typos corrected. To appear in Physical Review

Blue spectra and induced formation of primordial black holes

We investigate the statistical properties of primordial black hole (PBH) formation in the very early Universe. We show that the high level of inhomogeneity of the early Universe leads to the formation of the first generation PBHs. %The existence of these PBHs This causes later the appearance of a dust-like phase of the cosmological expansion. We discuss here a new mechanism for the second generation of PBH formation during the dust-like phase. This mechanism is based on the coagulation process. We demonstrate that the blue power spectrum of initial adiabatic perturbations after inflation leads to overproduction of primordial black holes with $10^9$g$\le M\le10^{15}$g if the power index is $n\ge1.2$.Comment: 16 pages, 2 figure

Thermographic imaging in sports and exercise medicine: A Delphi study and consensus statement on the measurement of human skin temperature

This is an accepted manuscript of an article published by Elsevier in Journal of Thermal Biology on 18/07/2017, available online: https://doi.org/10.1016/j.jtherbio.2017.07.006 The accepted version of the publication may differ from the final published version.© 2017 Elsevier Ltd The importance of using infrared thermography (IRT) to assess skin temperature (tsk) is increasing in clinical settings. Recently, its use has been increasing in sports and exercise medicine; however, no consensus guideline exists to address the methods for collecting data in such situations. The aim of this study was to develop a checklist for the collection of tsk using IRT in sports and exercise medicine. We carried out a Delphi study to set a checklist based on consensus agreement from leading experts in the field. Panelists (n  =  24) representing the areas of sport science (n = 8; 33%), physiology (n = 7; 29%), physiotherapy (n = 3; 13%) and medicine (n = 6; 25%), from 13 different countries completed the Delphi process. An initial list of 16 points was proposed which was rated and commented on by panelists in three rounds of anonymous surveys following a standard Delphi procedure. The panel reached consensus on 15 items which encompassed the participants’ demographic information, camera/room or environment setup and recording/analysis of tsk using IRT. The results of the Delphi produced the checklist entitled “Thermographic Imaging in Sports and Exercise Medicine (TISEM)” which is a proposal to standardize the collection and analysis of tsk data using IRT. It is intended that the TISEM can also be applied to evaluate bias in thermographic studies and to guide practitioners in the use of this technique.Published versio

Supersymmetry and primordial black hole abundance constraints

We study the consequences of supersymmetry for primordial black hole (PBH) abundance constraints. PBHs with mass less than about 10^{11}g will emit supersymmetric particles when they evaporate. In most models of supersymmetry the lightest of these particles, the lightest supersymmetric particle (LSP), is stable and will hence survive to the present day. We calculate the limit on the initial abundance of PBHs from the requirement that the present day LSP density is less than the critical density. We apply this limit, along with those previously obtained from the effects of PBH evaporation on nucleosynthesis and the present day density of PBHs, to PBHs formed from the collpase of inflationary density perturbations, in the context of supersymmetric inflation models. If the reheat temperature after inflation is low, so as to avoid the overproduction of gravitinos and moduli, then the lightest PBHs which are produced in significant numbers will be evaporating around the present day and there are therefore no constraints from the effects of the evaporation products on nucleosynthesis or from the production of LSPs. We then examine models with a high reheat temperature and a subsequent period of thermal inflation. In these models avoiding the overproduction of LSPs limits the abundance of low mass PBHs which were previously unconstrained. Throughout we incorporate the production, at fixed time, of PBHs with a range of masses, which occurs when critical collapse is taken into account.Comment: 8 pages RevTeX file with 3 figures incorporated (uses RevTeX and epsf). Version to appear in Phys. Rev. D: minor change to calculation and added discussio