D-Branes and Topological Field Theories

In the presence of a D-brane a string theory develops a new subsector. We show that for curved D-branes the corresponding sector is a (partially twisted) topological field theory. We use this result to compute the degeneracy of 2-branes wrapped around $K3$ cycles as well as 3-branes wrapped around CY threefold vanishing 3-cycles. In both cases we find the degeneracy is in accord with expectation. The counting of BPS states of a gas of 0-branes in the presence of a 4-brane in $K3$ is considered and it is noted that the effective 0-brane charge is shifted by 1, due to a quantum correction. This is in accord with string duality and the fact that left-moving ground state energy of heterotic string starts at $-1$. We also show that all the three different topological twistings of four dimensional $N=4$ Yang-Mills theory do arise from curved three-branes embedded in different spaces (Calabi-Yau manifolds and manifolds with exceptional holonomy groups).Comment: 22 page

Nutritional intervention and impact of polyphenol on glycohaemoglobin (HbA1c) in non-diabetic and type 2 diabetic subjects: systematic review and meta-analysis

Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties. Recently, their antiglycative actions by oxidative stress modulation have been linked to prevention of diabetes and associated complications. This paper assesses the evidence for polyphenol interventions on glycohaemoglobin (HbA1c) in non-diabetic, pre-diabetic and type 2 diabetes mellitus (T2DM) subjects. A systematic review of polyphenols clinical trials on HbA1c in humans was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis. Thirty-six controlled randomized trials with HbA1c values were included. Polyphenols (extracts, supplements, foods), were supplemented (28 mg to 1.5g) for 0.7 to 12 months. Combining all subjects (n=1954, mean baseline HbA1c=7.03%, 53 mmol/mol), polyphenol supplementation significantly (p<0.001) lowered HbA1c% by -0.53±0.12 units (-5.79±0.13 mmol/mol). This reduction was significant (p<0.001) in T2DM subjects, specifically (n=1426, mean baseline HbA1c=7.44%, 58 mmol/mol), with HbA1c% lowered by -0.21±0.04 units (-2.29±0.4 mmol/mol). Polyphenol supplementation had no significant effect (p>0.21) in the non-diabetic (n=258, mean baseline HbA1c=5.47%, 36 mmol/mol) and the pre-diabetic subjects (n=270, mean baseline HbA1c=6.06%, 43 mmol/mol) strata: -0.39±0.27 HbA1c% units (-4.3±0.3 mmol/mol), and -0.38±0.31 units (-4.2±0.31 mmol/mol), respectively. In conclusion, polyphenols can successfully reduce HbA1c in T2DM, without any intervention at glycaemia, and could contribute to the prevention of diabetes complications

D-Strings on D-Manifolds

We study the mechanism for appearance of massless solitons in type II string compactifications. We find that by combining $T$-duality with strong/weak duality of type IIB in 10 dimensions enhanced gauge symmetries and massless solitonic hypermultiplets encountered in Calabi-Yau compactifications can be studied perturbatively using D-strings (the strong/weak dual to type IIB string) compactified on ``D-manifolds''. In particular the nearly massless solitonic states of the type IIB compactifications correspond to elementary states of D-strings. As examples we consider the D-string description of enhanced gauge symmetries for type IIA string compactification on ALE spaces with $A_n$ singularities and type IIB on a class of singular Calabi-Yau threefolds. The class we study includes as a special case the conifold singularity in which case the perturbative spectrum of the D-string includes the expected massless hypermultiplet with degeneracy one.Comment: 23 pages, with 3 figures. A compact example is adde

Spontaneous Parity Violation in QCD At Finite Temperature: On the Inapplicability of the Vafa-Witten Theorem

The generalization of the Vafa-Witten theorem ruling out parity violation to QCD at finite temperature is considered. It is shown that this generalization of the theorem rules out Lorentz-invariant parity violating operators from spontaneously acquiring vacuum expectation values. However, it does not rule out Lorentz-noninvariant parity-violating operators from acquiring expectation values. Other situations where the theorem is inapplicable are also discussed.Comment: Minor typos correcte

Superpotentials from flux compactifications of M-theory

In flux compactifications of M-theory a superpotential is generated whose explicit form depends on the structure group of the 7-dimensional internal manifold. In this note, we discuss superpotentials for the structure groups: G_2, SU(3) or SU(2). For the G_2 case all internal fluxes have to vanish. For SU(3) structures, the non-zero flux components entering the superpotential describe an effective 1-dimensional model and a Chern-Simons model if there are SU(2) structures.Comment: 10 page

A-Model Correlators from the Coulomb Branch

We compute the contribution of discrete Coulomb vacua to A-Model correlators in toric Gauged Linear Sigma Models. For models corresponding to a compact variety, this determines the correlators at arbitrary genus. For non-compact examples, our results imply the surprising conclusion that the quantum cohomology relations break down for a subset of the correlators.Comment: 27 pages, 1 xy-pic figur

Producing a Scale-Invariant Spectrum of Perturbations in a Hagedorn Phase of String Cosmology

We study the generation of cosmological perturbations during the Hagedorn phase of string gas cosmology. Using tools of string thermodynamics we provide indications that it may be possible to obtain a nearly scale-invariant spectrum of cosmological fluctuations on scales which are of cosmological interest today. In our cosmological scenario, the early Hagedorn phase of string gas cosmology goes over smoothly into the radiation-dominated phase of standard cosmology, without having a period of cosmological inflation.Comment: 4 pages, 1 figur

F-theory, Geometric Engineering and N=1 Dualities

We consider geometric engineering of N=1 supersymmetric QFTs with matter in terms of a local model for compactification of F-theory on Calabi-Yau fourfold. By bringing 3-branes near 7-branes we engineer N=1 supersymmetric $SU(N_c)$ gauge theory with $N_f$ flavors in the fundamental. We identify the Higgs branch of this system with the instanton moduli space on the compact four dimensional space of the 7-brane worldvolume. Moreover we show that the Euclidean 3-branes wrapped around the compact part of the 7-brane worldvolume can generate superpotential for $N_f=N_c-1$ as well as lead to quantum corrections to the moduli space for $N_f=N_c$. Finally we argue that Seiberg's duality for N=1 supersymmetric QCD may be mapped to T-duality exchanging 7-branes with 3-branes.Comment: 15 page

Topological Reduction of 4D SYM to 2D σ\sigma--Models

By considering a (partial) topological twisting of supersymmetric Yang-Mills compactified on a 2d space with `t Hooft magnetic flux turned on we obtain a supersymmetric $\sigma$-model in 2 dimensions. For N=2 SYM this maps Donaldson observables on products of two Riemann surfaces to quantum cohomology ring of moduli space of flat connections on a Riemann surface. For N=4 SYM it maps $S$-duality to $T$-duality for $\sigma$-models on moduli space of solutions to Hitchin equations.Comment: 30 pages, harvma

Superstrings with new supersymmetry in (9,2) and (10,2) dimensions

We construct superstring theories that obey the new supersymmetry algebra {Q_a , Q_b}=\gamma_{ab}^{mn} P_{1m} P_{2n}, in a Green-Schwarz formalism, with kappa supersymmetry also of the new type. The superstring is in a system with a superparticle so that their total momenta are $P_{2n},P_{1m}$ respectively. The system is covariant and critical in (10,2) dimensions if the particle is massless and in (9,2) dimensions if the particle is massive. Both the superstring and superparticle have coordinates with two timelike dimensions but each behaves effectively as if they have a single timelike dimension. This is due to gauge symmetries and associated constraints. We show how to generalize the gauge principle to more intricate systems containing two parts, 1 and 2. Each part contains interacting constituents, such as p-branes, and each part behaves effectively as if they have one timelike coordinate, although the full system has two timelike coordinates. The examples of two superparticles, and of a superparticle and a superstring, discussed in more detail are a special cases of such a generalized interacting system.Comment: LaTeX, revtex, 9 page