Identification of functional information subgraphs in cultured neural networks

This paper accompanies an oral presentation on the identification of functional information subgraphs in cultured neural networks

Seasonal Propagation Characteristics of MSTIDs Observed at High Latitudes Over Central Alaska Using the Poker Flat Incoherent Scatter Radar

Near‐continuous electron density measurements obtained over a ∼3 year period, 2010–2013, using the Poker Flat Incoherent Scatter Radar (PFISR) in central Alaska (69°N, 147°W) have been analyzed to quantify the properties of over 650 high‐latitude medium‐scale traveling ionospheric disturbances (MSTIDs). Our analysis focused on the altitude range 100–300 km encompassing the lower ionosphere/thermosphere and yielded first full seasonal day/night distributions of MSTIDs at high northern latitudes with mean values: horizontal wavelength 446 km, horizontal phase speed 187 m/s, and period 41 min. These year‐round measurements fill an important summertime gap in existing MSTID measurements revealing predominantly eastward wave propagation during the summer, while continued winter season observations agree well with previous reports of near southward propagating MSTIDs. Our 3 years of results suggest a cyclic change in the seasonal horizontal propagation directions that was found to be quantitatively consistent with critical level wind and dissipative filtering. Concurrent measurements of the vertical wavelength spectrum as a function of altitude also compared favorably in shape with that calculated using a theoretical dispersion relation (Vadas & Fritts, 2005, https://doi.org/10.1029/2004JD005574) for the thermosphere, but with a higher mean value. Evidence supporting the systematic broadening and shrinking in the azimuthal distributions of the MSTIDs during the course of the year was also found, as well as an unexpected correlation between the MSTID propagation directions and the AE index, both of which are under further investigation

Density-dependence of functional development in spiking cortical networks grown in vitro

During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of neuronal interactions in vitro. Two types of cortical networks, dense and sparse, with 50,000 and 12,000 total cells respectively, are studied. Activation graphs that represent pairwise neuronal interactions are constructed using a competitive first response model. These graphs reveal that, during development in vitro, dense networks form activation connections earlier than sparse networks. Link entropy analysis of dense net- work activation graphs suggests that the majority of connections between electrodes are reciprocal in nature. Information theoretic measures reveal that early functional information interactions (among 3 cells) are synergetic in both dense and sparse networks. However, during later stages of development, previously synergetic relationships become primarily redundant in dense, but not in sparse networks. Large link entropy values in the activation graph are related to the domination of redundant ensembles in late stages of development in dense networks. Results demonstrate differences between dense and sparse networks in terms of informational groups, pairwise relationships, and activation graphs. These differences suggest that variations in cell density may result in different functional specialization of nervous system tissue in vivo.Comment: 10 pages, 7 figure

A Case of Anaphylaxis After the Ingestion of Yacon

Anaphylaxis is a potentially life-threatening systemic allergic reaction, often with an explosive onset; the symptoms range from mild flushing to upper respiratory obstruction, with or without vascular collapse. Foods are common offending allergens and remain the leading cause of outpatient anaphylaxis in most surveys. Yacon (Smallanthus sonchifolius) is a plant native to the Andes region, where its root is cultivated and consumed mainly as food. Unlike most edible roots, yacon contains large amounts of ructooligosaccharides. Traditionally, yacon tubers have been used as a source of natural sweetener and syrup for people suffering from various disorders. We report the case of a 55-year-old woman who developed syncope and generalized urticaria after ingesting yacon roots. The patient had positive skin prick and intradermal tests to yacon extract. An open food challenge test was performed to confirm food anaphylaxis and was positive 10 minutes after the consumption of yacon roots. To our knowledge, this is the first reported case of anaphylaxis after the ingestion of yacon roots

Long-term and trans-life-cycle effects of exposure to ocean acidification in the green sea urchin Strongylocentrotus droebachiensis

Anthropogenic CO2 emissions are acidifying the world’s oceans. A growing body of evidence demonstrates that ocean acidification can impact survival, growth, development and physiology of marine invertebrates. Here, we tested the impact of long-term (up to 16 months) and trans-life-cycle (adult, embryo/larvae and juvenile) exposure to elevated pCO2 (1,200 μatm, compared to control 400 μatm) on the green sea urchin Strongylocentrotus droebachiensis. Female fecundity was decreased 4.5-fold when acclimated to elevated pCO2 for 4 months during reproductive conditioning, while no difference was observed in females acclimated for 16 months. Moreover, adult pre-exposure for 4 months to elevated pCO2 had a direct negative impact on subsequent larval settlement success. Five to nine times fewer offspring reached the juvenile stage in cultures using gametes collected from adults previously acclimated to high pCO2 for 4 months. However, no difference in larval survival was observed when adults were pre-exposed for 16 months to elevated pCO2. pCO2 had no direct negative impact on juvenile survival except when both larvae and juveniles were raised in elevated pCO2. These negative effects on settlement success and juvenile survival can be attributed to carry-over effects from adults to larvae and from larvae to juveniles. Our results support the contention that adult sea urchins can acclimate to moderately elevated pCO2 in a matter of a few months and that carry-over effects can exacerbate the negative impact of ocean acidification on larvae and juveniles