RF-induced transport of resonant minority species in ICRF-heated tokamaks

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1996.Includes bibliographical references (leaves 186-191).by Luigi Vacca.Ph.D

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests

INTRODUCTION: Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS: Forty-one SSc patients, asymptomatic for coronary artery disease, were tested for coronary flow velocity reserve (CFR) by transthoracic-echo-Doppler with adenosine infusion (A-TTE) and for left ventricular wall motion abnormalities (WMA) by dobutamine stress echocardiography (DSE). Myocardial multi-detector computed tomography (MDCT) enabled the presence of epicardial stenosis, which could interfere with the accuracy of the tests, to be excluded. Patient survival rate was assessed over a 6.7- ± 3.5-year follow-up. RESULTS: Nineteen out of 41 (46%) SSc patients had a reduced CFR (≤2.5) and in 16/41 (39%) a WMA was observed during DSE. Furthermore, 13/41 (32%) patients showed pathological CFR and WMA. An inverse correlation between wall motion score index (WMSI) during DSE and CFR value (r = -0.57, P <0.0001) was observed; in addition, CFR was significantly reduced (2.21 ± 0.38) in patients with WMA as compared to those without (2.94 ± 0.60) (P <0.0001). In 12 patients with abnormal DSE, MDCT was used to exclude macrovasculopathy. During a 6.7- ± 3.5-year follow-up seven patients with abnormal coronary functional tests died of disease-related causes, compared to only one patient with normal tests. CONCLUSIONS: A-TTE and DSE tests are useful tools to detect non-invasively pre-clinical microcirculation abnormalities in SSc patients; moreover, abnormal CFR and WMA might be related to a worse disease outcome suggesting a prognostic value of these tests, similar to other myocardial diseases

Models and Heuristics for the Tactical Berth Allocation Problem with Quay-Crane Assignment and Transshipment Costs

In the context of international sea-freight container transport, we study an integrated decision problem arising in container terminal management. We consider the integration of the Berth Allocation Problem (BAP), which consists of assigning and scheduling incoming ships to berthing positions, and the Quay Crane Assignment Problem (QCAP), which assigns to incoming ships a certain QC profile (i.e. number of quay cranes per working shift). BAP and QCAP are strictly correlated, since the QC profile assigned to the incoming ships affects their handling time and has thus an impact on the berth allocation. In particular, we solve this problem at the tactical decision level, with the intent of supporting the terminal in its negotiation process with shipping lines, as the number of quay cranes is usually bounded by contracts which are discussed months in advance. With our analytical tools, we aim to allow terminal managers to assign the right value to the QC profiles proposed to shipping lines, taking into account the impact on the terminal productivity. In addition to profile evaluation, the combined solution of BAP and QCAP optimizes the utilization of terminal resources. In this work, two mixed integer formulations are presented with a quadratic and a linearized objective function, respectively. The objective function aims, on the one hand, to maximize the total value of chosen QC profiles and, on the other hand, to minimize the housekeeping costs caused by transshipment flows between ships. Both models have been validated on instances based on real data provided by MCT, a transshipment container terminal in the south of Italy. Computation confirms that the problem is hardly solvable via exact methods, hence we introduce heuristic methods, in order to find good feasible solutions in a reasonable amount of time. The proposed heuristic algorithm is based on tabu search and decomposition: each iteration consists in two phases, one aimed at finding a feasible profile assignment, the other at finding a feasible solution of the restricted problem obtained by fixing profile variables. Computational results are presented and discussed

The Tactical Berth Allocation Problem (TBAP) with quay crane assignment and transshipment-related quadratic yard costs

International sea-freight container transport has grown dramatically over the last years and container terminals play nowadays a key-role in the global shipping network. Increasing competition and competitiveness among terminals require more and more efficiency in container handling operations, both in the quayside and the landside, in order to better utilize limited resources (such as cranes, trucks, berths, storage space, etc.) as well as minimize ship's turnaround time. Operations research methods are therefore worth being use for the optimization of terminal operations. We take into account two decision problems which are usually solved hierarchically by terminal planners: the Berth Allocation Problem (BAP), which consists of assigning and scheduling incoming ships to berthing positions, and the Quay Crane Assignment Problem (QCAP), which assigns to incoming ships a certain QC profile (i.e. number of quay cranes per working shift). These two problems are indeed strictly correlated: the QC profile assigned to the incoming ships affects their handling time and has thus an impact on the berth allocation. In this work, we aim to combine BAP with QCAP and analyze the resulting new integrated problem from the point of view of a transshipment terminal. We solve this problem at the tactical decision level, with the intent of supporting the terminal in its negotiation process with shipping lines, as the number of quay cranes is usually bounded by contracts which are discussed months in advance. Devised analytic tools and quantitative methods allow terminal managers to assign the right value to the QC profiles proposed to shipping lines, considering their impact on the terminal productivity. In addition to profile evaluation, the combined solution of these two problems optimizes the utilization of terminal resources. Alternative objectives are used for this purpose, such as the minimization of total distance covered to move containers, the minimization of ships turnaround time, etc. Starting from a collaboration with the transshipment terminal of Gioia Tauro in Italy, one of the busiest in Europe, we propose a new model for the Tactical Berth Allocation Problem (TBAP) with Quay Crane Assignment, which has been validated on real-world instances provided by the terminal, taking into account a time horizon up to one month. The objective function aims, on the one hand, to maximize the total value of chosen QC profiles and, on the other hand, to minimize the housekeeping costs caused by transshipment flows between ships. Preliminary results obtained through commercial software will be presented and further methodological approaches to the problem, such as decomposition techniques, will be outlined

Modeling and Solving the Tactical Berth Allocation Problem

In this paper we integrate at the tactical level two decision problems arising in container terminals: the berth allocation problem, which consists of assigning and scheduling incoming ships to berthing positions, and the quay crane assignment problem, which assigns to incoming ships a certain QC profile (i.e. number of quay cranes per working shift). We present two formulations: a mixed integer quadratic program and a linearization which reduces to a mixed integer linear program. The objective function aims, on the one hand, to maximize the total value of chosen QC profiles and, on the other hand, to minimize the housekeeping costs generated by transshipment flows between ships. To solve the problem we developed a heuristic algorithm which combines tabu search methods and mathematical programming techniques. Computational results on instances based on real data are presented and compared to those obtained through a commercial solver

Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin.

Isoprostanes are prostaglandin isomers produced from the peroxidation of polyunsaturated fatty acids from the cellular membrane. They have been used as a specific index of cellular lipoperoxidation and as an indirect measure of oxidative stress. However, these molecules also present several biological activities. An oxidative environment measured as the presence of other indirect measurements of reactive oxygen species lipoperoxidation has recently been described in basal cell carcinoma, the most frequent type of non-melanoma skin cancer. This study aims to measure the levels of 8-isoprostaglandin F2α, an isoprostane widely studied in other models as a by-product of ROS-induced lipid peroxidation, in basal cell carcinoma and in UVA irradiated healthy skin. We found that 8-iso-PGF2α is present in higher levels in BCC specimens compared to healthy non sun-exposed skin, confirming previous studies on the production of lipoperoxidation in this tumor. Moreover, we demonstrated that topical pre-treatment with a compound containing vitamin E is capable of reducing 8-iso-PGF2α formation in UV irradiated skin suggesting a role for isoprostanes in UV induced inflammation and eventually carcinogenesis and confirming the function of vitamin E as an antioxidant in this model

The mandibular condyle as uncommon metastatic site of neuroendocrine carcinoma: Case report and review of literature

Temporo-mandibular joint (TMJ) metastases are a very rare event and only 73 cases are reported in literature. In about 40% of cases condylar metastases represent the first clinical manifestation of a tumor of elsewhere and may then allow an early diagnosis. However, the identification of this tumoral process can be difficult as in over 50% of the cases it has a nuanced clinical presentation that is very similar to temporo-mandibular disorders. The first case of metastatic neuroendocrine carcinoma (NEC) of the temporo-mandibular joint (TMJ) mimicking a temporo-mandibular joint disorder is presented in this report. Furthermore, an extensive review of the literature has been performed in order to establish a correct diagnosticâ\u80\u93therapeutic protocol for these oncologic patients

Terrestrial Laser Scanner and Close Range Photogrammetry point clouds accuracy assessment for the structure deformations monitoring

In this paper we show the results of several tests carried out using methods and instrumentation typical of an architectural survey, along with a set of metrological instrumentation, on a Reinforced Concrete (RC) beam subjected to increasing loads. The goal was to assess the accuracy in the displacements estimated by a medium quality terrestrial laser scanner (TLS) Focus 3d from Faro Technologies, and the low-cost digital camera Canon PowerShot S110 used in a Close Range Photogrammetry (CRP) survey. The software used for scan-data and point clouds processing was Reconstructor JRC Software v. 3.1.0, maintained by Gexcel Ltd, while the images processing was performed with the software Photoscan from Agisoft, which implements Structure from Motion (SfM) approach. Two processing strategies were used in the point clouds comparison: mesh2mesh and modelling the beam behavior fitting the contours of the beam with second order polynomials. Comparisons between the TLS and CRP techniques and the metrological equipment used in parallel highlighted the limits and potentialities of the two geomatic techniques used. It has been shown that modeling the behavior of the beam leads to significantly better results than using the mesh2mesh comparison. For the CRP the increase in accuracy was in the order of 40%, while for the TLS of 50%

Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines

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Epha3 acts as proangiogenic factor in multiple myeloma

This study investigates the role of ephrin receptor A3 (EphA3) in the angiogenesis of Multiple Myeloma (MM) and the effects of a selective target of EphA3 by a specific monoclonal antibody on primary bone marrow endothelial cells (ECs) of MM patients.EphA3 mRNA and protein were evaluated in ECs of MM patients (MMECs), in ECs of patients with monoclonal gammopathies of undetermined significance (MGECs) and in ECs of healthy subjects (control ECs). The effects of EphA3 targeting by mRNA silencing (siRNA) or by the anti EphA3 antibody on the angiogenesis were evaluated. We found that EphA3 is highly expressed in MMECs compared to the other EC types. Loss of function of EphA3 by siRNA significantly inhibited the ability of MMECs to adhere to fibronectin, to migrate and to form tube like structures in vitro, without affecting cell proliferation or viability. In addition, gene expression profiling showed that knockdown of EphA3 down modulated some molecules that regulate adhesion, migration and invasion processes. Interestingly, EphA3 targeting by an anti EphA3 antibody reduced all the MMEC angiogenesis-related functions in vitro. In conclusion, our findings suggest that EphA3 plays an important role in MM angiogenesis